PTK2B

  • Official Full Name

    protein tyrosine kinase 2 beta

  • Overview

    This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    PTK2B; protein tyrosine kinase 2 beta; PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; protein-tyrosine kinase 2-beta; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; PTK2B protein tyrosine kinase 2 beta; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTK2B-570H Active Recombinant Human PTK2B, His-tagged Sf9 Insect Cell His
Human PTK2B-164HFL Active Recombinant Full Length Human PTK2B Protein, N-His-tagged Sf21 His Full Length
Human PTK2B-701H Recombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, GST-His Sf9 Insect Cell GST
Human PTK2B-414H Recombinant Human PTK2B, His-tagged, Active Sf9 Insect Cell His
Human PTK2B-1903H Recombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, GST-tagged Insect Cell GST
Human PTK2B-1904H Recombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, His-tagged Sf9 Insect Cell His
Human PTK2B-743H Recombinant Human PTK2B, GST-tagged Insect Cell GST
Human PTK2B-74H Recombinant Human PTK2B protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PTK2B-2698HCL Recombinant Human PTK2B 293 Cell Lysate HEK293 N/A
Human PTK2B-836H Recombinant Human PTK2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK2B-4719H Recombinant Human PTK2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK2B-545H Recombinant Human PTK2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTK2B-6230HF Active Recombinant Full Length Human PTK2B Protein, GST-tagged Insect (sf21) GST 1-967(end)
Human PTK2B-1540HF Active Recombinant Full Length Human PTK2B Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-967(end)
Human PTK2B-1797H-B Recombinant Human PTK2B Protein Pre-coupled Magnetic Beads HEK293
Human PTK2B-1797H Recombinant Human PTK2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTK2B-1427HFL Recombinant Full Length Human PTK2B Protein, C-Flag-tagged Mammalian cells Flag
Mouse Ptk2b-6813M Recombinant Mouse Ptk2b protein, His & GST-tagged E.coli His/GST Ile704~Gly941 (Accession # Q9QVP9)
Mouse Ptk2b-5227M Recombinant Mouse Ptk2b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTK2B-4823R Recombinant Rat PTK2B Protein Mammalian Cell His
Rat PTK2B-4482R Recombinant Rat PTK2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTK2B-4482R-B Recombinant Rat PTK2B Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PTK2B involved in several pathways and played different roles in them. We selected most pathways PTK2B participated on our site, such as Calcium signaling pathway, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayTNNC1A;MYLK4;HTR2A;SLC25A31;P2RX2;P2RX4A;ADORA2AB;P2RX3B;ADRB3
Chemokine signaling pathwayPLCB3;CCL23;ROCK2;GNAI3;GRK5;PIK3CB;GM10591;CCL14;CCR5
Phospholipase D signaling pathwayPLA2G4A;PIP5K1B;PIP5K1C;PDGFB;MRAS;SHC4;GAB2;GNA12;MAPK1
Natural killer cell mediated cytotoxicityICAM1;HCST;NCR2;KLRC2;IFNA13;PRKCB;SAMD3;PIK3CD;PPP3R1
Leukocyte transendothelial migrationMYL12A;NIPAL1;MAPK13;PIK3R5;PIK3R2;ARHGAP35;ITGAM;MAPK12;CLDN3
GnRH signaling pathwayRAF1;HRAS;CACNA1C;PLA2G4AA;MAP2K2B;MMP2;GRB2A;MAPK7;PLA2G4F
Hepatitis BIFNA21;EP300;MAVS;IFNA7;NFATC4;PTK2B;SMAD4;VDAC3;FOS

PTK2B has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase binding, ATP binding, contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2B itself. We selected most functions PTK2B had, and list some proteins which have the same functions with PTK2B. You can find most of the proteins on our site.

Function Related Protein
3-phosphoinositide-dependent protein kinase binding
ATP bindingMYO1E;FKBP4;EPHB6;MLH3;CLCN3;PRKCBB;MAP2K2A;JAK2;UCK2
contributes_to NMDA glutamate receptor activityGRIN2A;GRIN1;GRIN3A;PTK2B
calmodulin-dependent protein kinase activityMKNK1;DCX;PNCK;DAPK2A;PTK2B;CAMK2B;CAMK2G1;CAMK2D1;MAPKAPK2A
non-membrane spanning protein tyrosine kinase activityTXK;JAK3;WEE2;PTK6B;STYK1;FYN;CLK1;ZAP70;PTK2BB
protein bindingSGSM3;PDE4D;CD151;CDC14B;XCL2;FDX1L;PAX8;DNAJB9;UBE2B
protein complex bindingPAFAH1B1;PPIB;CYFIP1;RXRA;STK11;TUB;PPP1R9B;RAP1B;UFD1L
protein tyrosine kinase activityCSK;ROS1;BMX;TEK;BCR;BLK;JAK1;TNK2;DYRK4
receptor bindingPLA2G1B;Ren1;ACOX1;KNG1;ASIP;GSTM2;MSN;LAMA4;P2RX4
signal transducer activitySTAT3;GNRHR1;RHOC;OLFR147;MTNR1AL;V1RA8;APOL3;FPR3;GPR30

PTK2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2B.

SRC; RHOU; FYN; MATK; MAP3K4; ERBB2; HSP90AB1; PDCD6IP; MYD88; yopM; q8ckf8_yerpe; q8ckm0_yerpe

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is PTK2B protein expression measured in clinical settings? 11/19/2022

PTK2B protein expression can be assessed using techniques like Western blotting and immunohistochemistry.

What are the challenges in developing PTK2B-targeted therapies? 10/27/2022

One of the challenges is achieving specificity in targeting PTK2B without affecting other related proteins or pathways.

Are there any drugs that target PTK2B protein? 06/22/2019

Several small molecule inhibitors targeting PTK2B are being developed as potential therapeutics for cancer and other diseases.

Can PTK2B protein be used as a diagnostic marker for any diseases? 06/09/2019

PTK2B protein expression has been explored as a potential diagnostic marker for certain cancers and neurodegenerative disorders.

Can PTK2B protein be targeted for therapeutic purposes? 12/21/2018

Yes, PTK2B is a potential therapeutic target for cancer, neurodegenerative diseases, and cardiovascular conditions.

Customer Reviews (3)

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Reviews
11/10/2021

    PTK2B protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

    04/28/2021

      PTK2B protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

      07/04/2018

        It enables accurate detection and quantification of PTK2B protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

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