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Recombinant Human PTPN22 protein, His & T7-tagged

Cat.No. : PTPN22-8103H
Product Overview : Recombinant Human PTPN22 aa. (Met1~Arg233 (Accession # Q9Y2R2)) fused with N-terminal His & T7 tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 31.1kDa.
Protein length : Met1~Arg233 (Accession # Q9Y2R2)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.8.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile ddH2O.
Gene Name : PTPN22 protein tyrosine phosphatase, non-receptor type 22 [ Homo sapiens (human) ]
Official Symbol : PTPN22
Gene ID : 26191
mRNA Refseq : NM_001193431.2
Protein Refseq : NP_001180360.1
UniProt ID : Q9Y2R2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Which single nucleotide polymorphism (SNP) in PTPN22 is associated with an increased risk of Type 1 Diabetes (T1D) and other autoimmune diseases? 04/11/2022

The rs2476601 SNP in PTPN22 is associated with an increased risk of Type 1 Diabetes (T1D) and other autoimmune diseases.

What controversy exists regarding the effect of the minor allele on PTPN22 function in TCR signaling? 12/19/2021

Controversy exists over whether the minor allele of rs2476601 enhances or reduces PTPN22 function in TCR signaling, leading to conflicting conclusions in different studies.

How has the minor allele of the rs2476601 SNP been reported to influence PTPN22 function in T cell receptor (TCR) signaling? 02/15/2021

The effect of the minor allele of rs2476601 on PTPN22 function in TCR signaling is controversial, with conflicting reports suggesting both enhanced and reduced function.

Besides TCR and B cell receptor (BCR) signaling, in which immune cells has PTPN22's function been studied, and what are the recent findings in these cells? 03/03/2019

PTPN22's function has been studied in monocytes, macrophages, dendritic cells, and neutrophils, revealing insights beyond TCR and BCR signaling.

What is the primary function of the PTPN22 protein in immune cells? 07/22/2017

The primary function of the PTPN22 protein is to regulate a variety of leukocyte signaling pathways in immune cells.

How do autoimmunity-associated variants of PTPN22 influence its core function in immune cells? 01/09/2017

Autoimmunity-associated variants of PTPN22 can influence its core function in immune cells, potentially contributing to dysregulated immune responses.

What are the unresolved questions regarding the role of PTPN22 in immune cell function, as mentioned in the review? 05/31/2016

Unresolved questions in the review highlight areas that require clarification, providing avenues for further research into the role of PTPN22 in immune cell function.

Customer Reviews (3)

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Reviews
11/01/2022

    Positive changes implemented by the manufacturer based on user input reflected a customer-centric approach.

    04/30/2022

      The compatibility with a range of lab equipment streamlined experimental procedures, saving both time and effort.

      09/24/2017

        We appreciated the straightforward incorporation of the product into our laboratory's instrumentation and automation systems.

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