Recombinant Human PTPN22 Protein, GST-tagged

• Cat.No.: PTPN22-01H
• Product Overview: Recombinant human PTPN22 (1-312) with a N-terminal GST tag was expressed in E. coli.

Specification

• Description: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: 63.3 kDa
• Protein length: 1-312
• Purity: 98% by SDS-PAGE and Coomassie blue staining.
• Applications: Phosphatase Assay

Gene Information

• Gene Name: PTPN22 protein tyrosine phosphatase non-receptor type 22 [ Homo sapiens (human) ]
• Official Symbol: PTPN22
• Synonyms: PTPN22; protein tyrosine phosphatase non-receptor type 22; LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6; tyrosine-protein phosphatase non-receptor type 22; PEST-domain phosphatase; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; EC 3.1.3.48
• Gene ID: 26191
• mRNA Refseq: NM_015967
• Protein Refseq: NP_057051
• MIM: 600716
• UniProt ID: Q9Y2R2