ptprk

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ptprk

Official Full Name protein tyrosine phosphatase, receptor type, K
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
Synonyms PTPRK; protein tyrosine phosphatase, receptor type, K; receptor-type tyrosine-protein phosphatase kappa; R PTP kappa; dJ480J14.2.1; DKFZp686C2268; DKFZp779N1045; OTTHUMP00000017180; OTTHUMP00000017181; OTTHUMP00000017182; OTTHUMP00000017187; OTTHUMP00000040306; Protein tyrosine phosphatase kappa; Protein tyrosine phosphatase kappa precursor; Protein tyrosine phosphatase receptor type K; Protein tyrosine phosphatase receptor type kappa; Protein-tyrosine phosphatase kappa; PTPK; PTPkappa; PTPRK_HUMAN; R-PTP-kappa; Receptor type tyrosine protein phosphatase kappa; OTTHUMP00000233054; OTTHUMP00000233055; OTTHUMP00000233080; protein-tyrosine phosphatase, receptor type, kappa; dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTPRK-1432H Recombinant Human PTPRK protein, His & T7-tagged E.coli His/T7
    Human PTPRK-3120H Recombinant Human PTPRK Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PTPRK-5497H Recombinant Human PTPRK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse PTPRK-13700M Recombinant Mouse PTPRK Protein Mammalian Cell His
    Mouse Ptprk-5248M Recombinant Mouse Ptprk Protein, Myc/DDK-tagged HEK293T Myc/DDK

    ptprk involved in several pathways and played different roles in them. We selected most pathways ptprk participated on our site, such as EGFR downregulation, Signal Transduction, Signaling by EGFR, which may be useful for your reference. Also, other proteins which involved in the same pathway with ptprk were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    EGFR downregulation AP2A2; PTPRK; SPRY2; AP2M1; AP2S1; SPRY1; STAM2; AP2B1; AP2A1
    Signal Transduction SST; RLN3; TLE4; FGD2; ARHGAP26; GPR77; ROR2; PYGO2; MYO7AA; DNAL4A
    Signaling by EGFR SPRY1; PTPRK; ADAM12; PAG1; LRIG1

    ptprk has several biochemical functions, for example, beta-catenin binding, gamma-catenin binding, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ptprk itself. We selected most functions ptprk had, and list some proteins which have the same functions with ptprk. You can find most of the proteins on our site.

    Function Related Protein
    beta-catenin binding VCL; NF2; PXN; CD2AP; PARK2; PTPRJ; SLC9A3R1; TBL1XR1; LEF1; GSK3B
    gamma-catenin binding DSG1A; TCF7L2; APC2; FER; Fert2; CTNNA1; DSG1; CDH2; CDH1; APC
    hydrolase activity MCM6L; PPM1BB; PTPN20; MPPED2A; PPP4CA; PPAPDC2; SACM1L; GGT7; SPPL3; HE2
    phosphatase activity C12orf5; SACM1LB; PTPRU; PTPN11A; MTMR7A; DUSP28; PTPREB; PTPN22; PTP4A2A; PGAM5
    phosphoprotein phosphatase activity PTPRU; PTPRJA; PTPRDB; CDC25D; PTPRFB; PTPN2A; CDC14AA; PPM1BB; PTPN20; DUSP26
    protein kinase binding BORA; PTPRR; MS4A2; GRB7; TMEM173; VRK1; CACNB3; Cd24a; CAV2; PTPN23
    protein tyrosine phosphatase activity PTPN20; DUSP23B; PTP4A2A; PALD1; PTPRUB; RNGTT; PTPRA; DNAJC6; PTPRG; CDC25D

    ptprk has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ptprk here. Most of them are supplied by our site. Hope this information will be useful for your research of ptprk.

    Ywhae

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