| Description : |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His & T7 |
| Form : |
Freeze-dried powder |
| Molecular Mass : |
Predicted Molecular Mass: 33.3kDa. |
| Protein length : |
Thr1185~Ser1440 (Accession # Q15262) |
| Endotoxin : |
<1.0EU per 1µg (determined by the LAL method). |
| Purity : |
>95% |
| Characteristic : |
The isoelectric point is 6. |
| Applications : |
SDS-PAGE; WB; ELISA; IP. |
| Stability : |
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage : |
Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Storage buffer : |
Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
| Reconstitution : |
Reconstitute in sterile PBS, pH7.2-pH7.4. |
