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PTPRM

Official Full Name

protein tyrosine phosphatase, receptor type, M
Overview

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tra
Synonyms

PTPRM; protein tyrosine phosphatase, receptor type, M; PTPRL1; receptor-type tyrosine-protein phosphatase mu; hR PTPu; RPTPU; protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; RP;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPRM-336H	Active Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, M	E.coli	Non		Inquiry
Human	PTPRM-219H	Active Recombinant Human PTPRM(879-1184) Protein, N-GST-tagged	E.coli	GST	879-1184 aa	Inquiry
Human	PTPRM-382H	Recombinant Human PTPRM, GST-tagged	Sf9 Insect Cell	GST	764-1452	Inquiry
Human	PTPRM-7017H	Recombinant Human PTPRM , GST-tagged	Sf9 Insect Cell	GST	764-1452 aa	Inquiry
Human	PTPRM-1861H	Recombinant Human PTPRM, GST-tagged	E.coli	GST		Inquiry
Human	PTPRM-5628H	Recombinant Human PTPRM protein, His & T7-tagged	E.coli	His&T7	Thr1197~Ser1403	Inquiry
Human	PTPRM-2384H	Recombinant Human PTPRM, GST-tagged	E.coli	GST	839-1100	Inquiry
Human	PTPRM-5469H	Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, M	E.coli	Non	839-1100	Inquiry
Human	PTPRM-6108H	Recombinant Human PTPRM Protein (Thr1197-Ser1403), N-His tagged	E.coli	His	Thr1197-Ser1403	Inquiry
Mouse	PTPRM-13701M	Recombinant Mouse PTPRM Protein	Mammalian Cell	His		Inquiry
Mouse	PTPRM-7288M	Recombinant Mouse PTPRM Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	PTPRM-7288M-B	Recombinant Mouse PTPRM Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PTPRM involved in several pathways and played different roles in them. We selected most pathways PTPRM participated on our site, such as Cell adhesion molecules (CAMs), Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell adhesion molecules (CAMs)	HLA-DRB3;Icosl;CD8A;CNTNAP1;CLDN11A;CD276;CDH15;CLDN15LA;GLYCAM1
Adherens junction	FARP2;RAC2;SSX2IP;TGFBR1A;Fert2;CSNK2B;RAC1;SNAI1;NLK2

PTPRM has several biochemical functions, for example, cadherin binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRM itself. We selected most functions PTPRM had, and list some proteins which have the same functions with PTPRM. You can find most of the proteins on our site.

Function	Related Protein
cadherin binding	TRPC4;AKAP5;CTNNB1;P2RX4;NUMB;PTPRM;FXYD5;CD2AP;NEO1
identical protein binding	DYNLT3;EPS15;TRIM23;ETNPPL;RALYL;SKP2;NUFIP1;CLDND;COL2A1
protein binding	ERG;WFDC9;TEC;SPI1B;SMO;F2RL1;MIS18A;MACROD1;PEX3
protein tyrosine phosphatase activity	EYA4;PTPN23A;MDP1;SSH2;DUSP19;MTMR7;DUSP22A;EPM2A;DUSP22
transmembrane receptor protein tyrosine phosphatase activity	PTPRO;PTPRG;PTPRM;EVLA;PTPRC;PTPRS;PTPRB;PTPRUB;PTPN6

PTPRM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRM here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRM.

LCK; Cdh1; Cdh2; Cdh4; nagA

Gene Family

Research Area

Adherens Junction Proteins in Endothelial Cells

Adherens Junction Proteins in VSMC

Phosphatases and Regulators

Luckerath, K; Kirkin, V; et al. Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. BLOOD 117:519-529(2011).

Charba, DS; Wiggins, RC; et al. Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 297:F138-F144(2009).