Recombinant Human PTPRM, GST-tagged

• Cat.No.: PTPRM-382H
• Product Overview: Recombinant human PTPRM (764-1452) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 110 kDa.

Specification

• Cat. No.: PTPRM-382H
• Description: PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
• Source: Sf9 insect cells using baculovirus.
• Sequence: 764-1452.
• Applications: Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ]
• Synonyms: PTPRM; protein tyrosine phosphatase, receptor type, M; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; EC 3.1.3.48
• Gene ID: 5797
• mRNA Refseq: NM_001105244
• Protein Refseq: NP_001098714
• MIM: 176888
• UniProt ID: P28827
• Chromosome Location: 18p11.2
• Pathway: Adherens junction; Cell adhesion molecules (CAMs)
• Function: cadherin binding; hydrolase activity; protein binding; receptor activity; transmembrane receptor protein tyrosine phosphatase activity