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RAD18

Official Full Name

RAD18 RAD18 homolog (S. cerevisiae)
Overview

The Rad6-Rad18 pair of genes plays a critical role in post-replication repair of damaged DNA. Rad6 protein functions as an E2 enzyme and Rad18 as a ubiquitine ligase.
Synonyms

RAD18; RAD18 homolog (S. cerevisiae); E3 ubiquitin-protein ligase RAD18; RNF73; hHR18; hRAD18; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
His
His (Fc)
Avi
His|SUMO
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAD18-29578TH	Recombinant Human RAD18	Wheat Germ	N/A	495 amino acids	Inquiry
Human	RAD18-29579TH	Recombinant Human RAD18	Wheat Germ	N/A	99 amino acids	Inquiry
Human	RAD18-2561HCL	Recombinant Human RAD18 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RAD18-1848H	Recombinant Human RAD18 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	RAD18-421HF	Active Recombinant Full Length Human RAD18 Protein	In Vitro Cell Free System		495 amino acids	Inquiry
Human	RAD18-1151H	Recombinant Human RAD18 Protein (1-495 aa), His-SUMO-tagged	E.coli	His/SUMO	1-495 aa	Inquiry
Human	RAD18-1848H-B	Recombinant Human RAD18 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	RAD18-529HFL	Active Recombinant Full Length Human RAD18 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Mouse	Rad18-5347M	Recombinant Mouse Rad18 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	RAD18-10488Z	Recombinant Zebrafish RAD18	Mammalian Cell	His		Inquiry
Chicken	RAD18-2315C	Recombinant Chicken RAD18	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

RAD18 involved in several pathways and played different roles in them. We selected most pathways RAD18 participated on our site, such as DNA Damage Bypass, DNA Repair, Recognition of DNA damage by PCNA-containing replication complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Damage Bypass	ZBTB32;DDB1;DTL;KIAA0101;USP10;POLD3;SPRTN;MAD2L2;POLI
DNA Repair	PARP1;WRN;BRE;BARD1;RAD9B;UBE2L6;RAD51AP1;COPS6;EME1
Recognition of DNA damage by PCNA-containing replication complex	ZBTB32;RAD18;DTL

RAD18 has several biochemical functions, for example, Y-form DNA binding, damaged DNA binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD18 itself. We selected most functions RAD18 had, and list some proteins which have the same functions with RAD18. You can find most of the proteins on our site.

Function	Related Protein
Y-form DNA binding	MSH3;MEN1;WRN;MSH2;RAD18
damaged DNA binding	APTX;ERCC3;BRCA1;RAD18;PCNA;NEIL3;TP63;TRPC2;HMGB1
ligase activity	RNF144A;UBR5;SMURF1;RBBP6;RFWD2;UBE2G1A;PJA2;RNF216;UBE2KB
polyubiquitin binding	HDAC6;UBQLN1;BRCC3;FAM175A;TNIP2;BRE;THRSP;DNAJB2;DZIP3
protein binding	USP42;KIF27;NLRP3;TNPO1;CDC42EP4;SDC2;MKRN3;CUL2;IQCE
protein complex binding	C8B;ERCC8;ABI2;ST13;LEPRE1;DLG4;PFKP;HNF1B;Casp3
single-stranded DNA-dependent ATPase activity	DNA2;RAD51;RAD18
ubiquitin protein ligase activity	ANAPC11;MED17;TRIM6;PELI1;PDZD4;UBE2B;RNF111;TRIM59;MDM2
ubiquitin protein ligase binding	UBE2KB;SCAMP3;FZD8;CASP8;TRIB2;RPA3;TRIB1;SMAD2;WASH1
zinc ion binding	MMP14;RAG2;MMP11;CPDB;PML;RNF20;RNF121;BHMT;ING1

RAD18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD18 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD18.

TAX1BP1; UBE2A; UBE2B; Map3k1; Smc6; TRIM23; UBE2I; DZIP3; MLKL; TSG101; PCGF6; TRIM8; SRGAP3; HK2; CREM