RAD23B
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Official Full Name
RAD23 homolog B
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Overview
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
RAD23B; RAD23 homolog B (S. cerevisiae); RAD23 (S. cerevisiae) homolog B; UV excision repair protein RAD23 homolog B; HHR23B; HR23B; P58; XP C repair complementing complex 58 kDa; XP C repair complementing protein; RAD23, yeast homolog of, B; XP-C repair;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
RAD23B involved in several pathways and played different roles in them. We selected most pathways RAD23B participated on our site, such as Nucleotide excision repair, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD23B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide excision repair | CUL4A;CUL4B;POLE4;COPS4;TFPT;RAD23B;RPA4;GTF2H1;RFC4 |
| Protein processing in endoplasmic reticulum | HSP70;BCL2A;RRBP1A;NFE2L2;DNAJB1A;CAPN2;SSR2;CUL1A;MAPK8A |
RAD23B has several biochemical functions, for example, damaged DNA binding, polyubiquitin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD23B itself. We selected most functions RAD23B had, and list some proteins which have the same functions with RAD23B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| damaged DNA binding | NEIL1;NEIL3;PCNA;RUVBL2;POLD1;OGG1;MGMT;RAD1;RAD23A |
| polyubiquitin binding | BRCC3;PSMD4A;PSMD4;VCP;UBQLN1;SHARPIN;TNIP2;UBQLN4;THRSP |
| protein binding | SLC30A1;TRAF3IP2;SPEF1;CTSZ;BRD7;SLC30A2;FHIT;UXT;MXD1 |
| single-stranded DNA binding | SSBP3;RAD51AP1;RAD23A;LRPPRC;RAD51C;CDC45;DDX11;RTF1;TTC6 |
RAD23B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD23B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD23B.
PSMD4; XPC; ATXN3; NGLY1
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