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RAD50

Official Full Name

RAD50 homolog
Overview

The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage. Rad50 forms a complex with Mre11 an
Synonyms

RAD50; RAD50 homolog (S. cerevisiae); RAD50 (S. cerevisiae) homolog; DNA repair protein RAD50; hRad50; RAD50 2; NBSLD; RAD502;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAD50-2557HCL	Recombinant Human RAD50 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RAD50-5516H	Recombinant Human RAD50 Protein (Thr437-Val792), N-His tagged	E.coli	N-His	Thr437-Val792	Inquiry
Human	RAD50-1744H	Recombinant Human RAD50 protein, His-tagged	E.coli	His	Val400~Ala595 (Accession # Q92878)	Inquiry
Human	RAD50-301476H	Recombinant Human RAD50 protein, GST-tagged	E.coli	GST	Leu275-Lys425	Inquiry
Mouse	Rad50-1746M	Recombinant Mouse Rad50 protein, His & T7-tagged	E.coli	His/T7	Met1~Leu234 (Accession # P70388)	Inquiry
Rat	RAD50-4910R	Recombinant Rat RAD50 Protein	Mammalian Cell	His		Inquiry
Rat	RAD50-4569R	Recombinant Rat RAD50 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RAD50-4569R-B	Recombinant Rat RAD50 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAD50 Related Articles
RAD50 Related Research Area

RAD50 involved in several pathways and played different roles in them. We selected most pathways RAD50 participated on our site, such as BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
BARD1 signaling events	RAD50;BARD1;RBBP8;CDK2;CSTF1;NPM1
Cell Cycle	GADD45AA;WRAP53;CENPW;CDC14AA;CCND2A;CDK6;YWHAG1;CDKN1BB;RBL2
Cell Cycle Checkpoints	BABAM1;HIST4H4;RAD1;CDKN1B;RAD9B;BRE;BARD1;HTATIP;RAD50
Cellular Senescence	ACD;CBX8B;UBN1;TNIK;HIST3H2BB;AGO1;HMGA1;PHC1;ASF1A
Cellular responses to stress	DPF1;TXN;RNF2;CBX8A;AMBRA1B;KAT5;CBX8B;HIF1AN;HMGA1-RS1
DNA Damage/Telomere Stress Induced Senescence	POT1A;POT1;HMGA1;HTATIP;UBN1;HMGA1-RS1;RAD50;TERF1;CABIN1
DNA Double Strand Break Response	HTATIP;EYA3;SMARCA5;BRE;EYA2;UIMC1;FAM175A;UBE2V2;CHEK2
DNA Double-Strand Break Repair	HTATIP;RAD51AP1;RNF168;RIF1;RAD9;EME2;BAZ1B;PPP4CA;TIMELESS

RAD50 has several biochemical functions, for example, contributes_to 3-5 exonuclease activity, ATP binding, contributes_to ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD50 itself. We selected most functions RAD50 had, and list some proteins which have the same functions with RAD50. You can find most of the proteins on our site.

Function	Related Protein
contributes_to 3-5 exonuclease activity
ATP binding	PRPS2;CENPE;ACTC1;PSTK;PRPF4BB;RPS6KC1;SMG1;FER;MAPKAPK2B
contributes_to ATP-dependent DNA helicase activity	MCM4;MCM7;NBN;RAD50;MRE11A;MCM6
DNA binding	ZNF423;DMBX1A;AIFM1;MXD4;ZNF620;ADNP2;XRCC5;KCNH7;NR1D1
metal ion binding	OVOL3;TRIM35-29;NUFIP1;ZKSCAN4;ZMYM2;EIF2S2;ITGA10;KAT5;RNF207
protein binding	PALLD;TXNIP;UBE2M;TBC1D15;FBN2;PMM2;HPCAL4;ACTL8;DOHH
protein binding, bridging	FKBP4;CNKSR1;NUFIP1;TRIM6;ANXA1;GOLGA5;EVPL;CBX5;MEN1
contributes_to single-stranded DNA endodeoxyribonuclease activity	ERCC1;RAD50

RAD50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD50 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD50.

NBN; MDC1; FANCD2; ATRX

Huang, S; Peet, CR; et al. Sym004, a Novel Anti-EGFR Antibody Mixture, Augments Radiation Response in Human Lung and Head and Neck Cancers. MOLECULAR CANCER THERAPEUTICS 12:2772-2781(2013).

Maiga, B; Dolo, A; et al. Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali. PLOS ONE 8:-(2013).

G2/M (DNA Damage) Checkpoints

Other DNA Repair