rad50

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rad50

Official Full Name RAD50 homolog
Background The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage. Rad50 forms a complex with Mre11 an
Synonyms RAD50; RAD50 homolog (S. cerevisiae); RAD50 (S. cerevisiae) homolog; DNA repair protein RAD50; hRad50; RAD50 2; NBSLD; RAD502
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RAD50-1744H Recombinant Human RAD50 protein, His-tagged E.coli His
    Human RAD50-2557HCL Recombinant Human RAD50 293 Cell Lysate HEK293 N/A
    Mouse Rad50-1746M Recombinant Mouse Rad50 protein, His & T7-tagged E.coli His/T7
    Rat RAD50-4910R Recombinant Rat RAD50 Protein Mammalian Cell His

    rad50 involved in several pathways and played different roles in them. We selected most pathways rad50 participated on our site, such as BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with rad50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BARD1 signaling events BARD1; CDK2; CSTF1; RAD50; RBBP8; NPM1
    Cell Cycle POT1; LIN9; MIS12; FKBP6; NDC80; MCM4; MDM2; DIDO1; ATM; NIPBL
    Cell Cycle Checkpoints HUS1; CHEK1; MCM8; RAD9B; RAD9A; CLSPN; RAD50; HIST3H2BB; RAD1; BRCC3
    Cellular Senescence TERF2; HIST4H4; CDKN2A; ERF; Txn1; CBX8A; H3F3B.1; HMGA1-RS1; HMGA1; HIST1H1A
    Cellular responses to stress NUP50; IGFBP7; HIST1H1B; RRAGA; GABARAP; POT1A; DYNLL2A; HIST2H3C; ST13; TERF1
    DNA Damage/Telomere Stress Induced Senescence HIST1H1B; POT1A; HIST1H1D; HMGA1-RS1; HIST1H1E; TERF2; ACD; HTATIP; TERF2IP; ASF1A
    DNA Double Strand Break Response SMARCA5; EYA2; EYA4; UIMC1; KDM4A; THRSP; BAZ1B; RAD50; EYA3; BARD1
    DNA Double-Strand Break Repair RIF1; EME1; BAZ1B; RAD50; HTATIP; FAM175A; TDP2; PAXIP1; EYA4; RAD17

    rad50 has several biochemical functions, for example, contributes_to 3-5 exonuclease activity, ATP binding, contributes_to ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by rad50 itself. We selected most functions rad50 had, and list some proteins which have the same functions with rad50. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to 3-5 exonuclease activity RAD50
    ATP binding PIM2; RPS6KB1B; ATP9A; EHD4; TTLL9; MCCC2; STK24; PAPSS2B; MAP3K1; DHX30
    contributes_to ATP-dependent DNA helicase activity MCM6; NBN; MCM7; MCM4; RAD50; MRE11A
    DNA binding POLA2; TOX2; RTEL1; TRIM21; PAX7B; ZNF576.2; DBN1; DRGX; NEUROD6; TRP53
    metal ion binding GTF3AA; SCRT1B; AIFM4; PHOSPHO2; TOP2B; NT5C3L; ZNF426; PVALB1; FRRS1; CNOT4B
    protein binding KRT40; RTF1; CRY1A; CHAMP1; ASIC2; KIAA1967; RNF13; CABP5; IL15; NEGR1
    protein binding, bridging NEFH; FBXW7; FGA; RAD50; ADAP2; BCL3; TRIM5; NUFIP1; FGG; TRIM22
    contributes_to single-stranded DNA endodeoxyribonuclease activity ERCC1; RAD50

    rad50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rad50 here. Most of them are supplied by our site. Hope this information will be useful for your research of rad50.

    NBN; MDC1; FANCD2; ATRX

    Huang, S; Peet, CR; et al. Sym004, a Novel Anti-EGFR Antibody Mixture, Augments Radiation Response in Human Lung and Head and Neck Cancers. MOLECULAR CANCER THERAPEUTICS 12:2772-2781(2013).
    Maiga, B; Dolo, A; et al. Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali. PLOS ONE 8:-(2013).

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