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Official Full Name retinol binding protein 3, interstitial
Background Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.
Synonyms RBP3; retinol binding protein 3, interstitial; retinol-binding protein 3; D10S64; D10S65; D10S66; Interphotoreceptor retinoid binding protein; Interphotoreceptor retinoid-binding protein; Interstitial retinol binding protein; Interstitial retinol-binding protein; IRBP; RBP 3; RBPI; RET3_HUMAN; Retinol binding protein 3; Retinol binding protein 3 interstitial; OTTHUMP00000019536
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RBP3-35H Recombinant Human RBP3 Protein, His-tagged Human Cells His
    Bovine RBP3-1501B Recombinant Bovine RBP3 Protein (633-1231 aa), His-tagged Yeast His
    Bovine RBP3-2329B Recombinant Bovine RBP3 Protein (933-1231 aa), GST-tagged E.coli GST
    Human RBP3-30611TH Recombinant Human RBP3 Wheat Germ N/A
    Human RBP3-511H Recombinant Human RBP3 Protein, His-tagged E.coli His
    Human RBP3-715H Recombinant Human RBP3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Rbp3-512M Recombinant Mouse Rbp3 Protein, His-tagged E.coli His
    Mouse Rbp3-513M Recombinant Mouse Rbp3 Protein, His-tagged E.coli His
    Rat Rbp3-514R Recombinant Rat Rbp3 Protein, His-tagged E.coli His
    Rat Rbp3-515R Recombinant Rat Rbp3 Protein, His-tagged E.coli His
    Chicken RBP3-2181C Recombinant Chicken RBP3 Mammalian Cell His

    rbp3 involved in several pathways and played different roles in them. We selected most pathways rbp3 participated on our site, such as Signal Transduction, The canonical retinoid cycle in rods (twilight vision), The retinoid cycle in cones (daylight vision), which may be useful for your reference. Also, other proteins which involved in the same pathway with rbp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signal Transduction RBBP5; RNF43; PRKCHB; OXGR1A.1; CBY1; NCKIPSD; METAP1; ADCYAP1B; TULP3; PNOC
    The canonical retinoid cycle in rods (twilight vision) RDH12; IRBP; RPE65B; DHRS9; RBP4; RLBP1B; RLBP1A; SDR9C7; RLBP1; ABCA4A
    The retinoid cycle in cones (daylight vision) OPN1LW2; OPN1SW1; DHRS3; DHRS3A; RLBP1B; OPN1LW1; RLBP1A; IRBP; RLBP1; RBP3
    Visual phototransduction PPEF1; DHRS9; CNGA1; APOA4B.1; LRP12; METAP2A; METAP2B; BCO2; CLPS; LRP10
    the visual cycle I (vertebrates) RBP3; DHRS4; RBP5

    rbp3 has several biochemical functions, for example, retinal binding, retinoid binding, retinol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by rbp3 itself. We selected most functions rbp3 had, and list some proteins which have the same functions with rbp3. You can find most of the proteins on our site.

    Function Related Protein
    retinal binding RBP7; RBP5; RBP4; CRABP2; RBP2A; CRABP1; RBP1; RBP2; RBP3; RBP2B
    retinoid binding CRABP2; RBP3; RBP1; RBP4L; CRABP1; LCN5; PTGDS; RBP2; RBP5
    retinol binding RBP4; CRABP1; RBP1; ADH4; LRAT; ADH7; C8G; RBP3; CRABP2; RBP2
    serine-type peptidase activity KLK1B22; C1RA; PRSS12; IMMP2L; PRSS8; ST14; KLK1B16; ENDOU; DPP4; ELA2

    rbp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with rbp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of rbp3.

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