RGMA

  • Official Full Name

    repulsive guidance molecule family member A

  • Overview

    Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • Synonyms

    RGMA; repulsive guidance molecule family member A; BC059072; C230063O06; repulsive guidance molecule A; RGM domain family, member A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Avi
  • Flag
  • His (Fc)
  • Myc
  • His|Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RGMA-7011H Recombinant Human RGMA protein(Met1-Gly422), His-tagged HEK293 C-His Met1-Gly422
Human RGMA-2416H Recombinant Human RGM Domain Family, Member A, FLAG-tagged HEK293 Flag
Human RGMA-2271H Recombinant Human RGMA, His-tagged E.coli His C-term-350aa
Human RGMA-1697HCL Recombinant Human RGMA cell lysate Human Cell N/A
Human RGMA-6376H Recombinant Human RGMA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RGMA-6034H Recombinant Human RGMA Protein (Pro169-Gly422), N-His tagged E.coli N-His Pro169-Gly422
Human RGMA-1043H Recombinant Human RGMA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RGMA-6035H Recombinant Human RGMA Protein (Met1-Gly422), C-His tagged Mammalian cells C-His Met1-Gly422
Human RGMA-4658H Recombinant Human RGMA protein, His&Myc-tagged E.coli His&Myc 169-424aa
Human RGMA-2748H Recombinant Human RGMA Protein (169-424 aa), His-MBP-tagged Insect Cell His/Myc 169-424 aa
Human RGMA-086H Recombinant Human RGMA protein, His-Avi-tagged HEK293 His-Avi Met 1-Pro 47
Human RGMA-1242H Recombinant Human RGMA protein, His-tagged HEK293 His Cys48-Gly422
Human RGMA-212H Recombinant Human RGMA Protein, Cys48-Gly422, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Cys48-Gly422
Mouse RGMA-14126M Active Recombinant Mouse Rgma protein, His-tagged Mammalian cells His
Mouse Rgma-2417M Recombinant Mouse RGM Domain Family, Member A, FLAG-tagged Human Cell Flag
Mouse Rgma-5488M Recombinant Mouse Rgma Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RGMA-7560M-B Recombinant Mouse RGMA Protein Pre-coupled Magnetic Beads HEK293
Mouse RGMA-7560M Recombinant Mouse RGMA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey RGMA-857R Recombinant Rhesus monkey RGMA Protein, His-tagged HEK293 His
Cynomolgus Monkey RGMA-856C Recombinant Cynomolgus RGMA Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey RGMA-599C-B Recombinant Cynomolgus Monkey RGMA Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey RGMA-599C Recombinant Cynomolgus Monkey RGMA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RGMA-3868R Recombinant Rhesus monkey RGMA Protein, His-tagged Mammalian Cell His
Rhesus Macaque RGMA-3685R-B Recombinant Rhesus Macaque RGMA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RGMA-3685R Recombinant Rhesus Macaque RGMA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RGMA-4088Z Recombinant Zebrafish RGMA Mammalian Cell His
Chicken RGMA-6106C Recombinant Chicken RGMA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

RGMA involved in several pathways and played different roles in them. We selected most pathways RGMA participated on our site, such as Axon guidance, BMP receptor signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceARHGEF12;EPHA2;DCX;DUSP10;EPHB3;MARK3;SPNA2;CAP1;COL9A1A
BMP receptor signalingSOSTDC1;CHRDL1;FST;CTDSP1;HFE2;SKI;CTDSPL;CALML4;RGMB
Developmental BiologyCOL9A1A;COL6A1;RGMA;GFRA1;DRAP1;TRPC4;PAQR3A;RHOC;DAB2IPB
Netrin-1 signalingTRPC5;RGMA;HFE2;RNF8;NTN1A;PITPNA;TRPC4;EZRA;RGMB
Spinal Cord InjuryLILRB3;TNFSF13B;OMG;RTN4;RGMA;AIF1;GAP43;PTPRZ1;MBP

RGMA has several biochemical functions, for example, coreceptor activity, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGMA itself. We selected most functions RGMA had, and list some proteins which have the same functions with RGMA. You can find most of the proteins on our site.

Function Related Protein
coreceptor activityACVR2A;CCR5;RGMD;CD4;CD28;CXCR4;LY96;TMIGD2;ZP2
glycoprotein bindingSHB;TGFB1;EDEM1;Serpina1b;FYN;FOXRED2;EDEM2;ERBB2;Itgam&Itgb2
protein bindingCARHSP1;EFCAB12;EHHADH;ADRA2C;C6orf130;MCM8;MACROD1;UBA3;WDR92
transferrin receptor bindingHFE;HFE2;CD81;Trf;SNX2;SNX4;TF;SNX1;RGMA

RGMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGMA here. Most of them are supplied by our site. Hope this information will be useful for your research of RGMA.

TERF2IP; SGSM2; PPP1R16A; BDP1; NCOR2; TCEB2; SAMD4B; NBEAL1; SPICE1; PPHLN1; ANO3; HIPK2; TXNIP; CLK4

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