|Official Full Name||Ras homolog enriched in brain|
|Background||Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins that was originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other Ras family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies suggest that Rheb plays an important role in regulating the insulin/mTOR signaling pathway.|
|Synonyms||RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
RHEB involved in several pathways and played different roles in them. We selected most pathways RHEB participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHEB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Phospholipase D signaling pathway||FCER1G; PIK3R5; PLCB4; SHC4; PLA2G4C; ARF6; TSC1; RHEB; MTOR; PDGFRA|
|mTOR signaling pathway||PIK3R1; AKT2; TNF; MLST8; ULK3; PTENB; RRAGCB; EIF4BA; RPS6KA3B; PIK3R3|
|PIK-Akt signaling pathway||TP53; IL4; PRL; COL6A6; COL6A4; IFNA14; FGF3; PDGFB; GNB4; FGF17|
|AMPK signaling pathway||PPP2R5B; CREB3L3; RPS6KB1; PIK3R3; PFKP; PPP2R5C; PIK3R5; PRKAG2; AKT1S1; LEP|
|Insulin signaling pathway||PPP1CA; PRKACG; PRKACAA; MTOR; G6PC; PIK3CB; RPS6KB2; PRKACAB; PPP1R3C; PRKACB|
|Thyroid hormone signaling pathway||THRA; KAT2A; PLCG1; FOXO1; NCOA3; PIK3CD; KRAS; HDAC3; ATP1A3; HIF1A|
|Choline metabolism in cancer||KRAS; TSC2; PLD2; CHKA; MAP2K2; RPS6KB1; PDGFB; EIF4EBP1; PIK3R3; PDGFC|
RHEB has several biochemical functions, for example, GTP binding, GTPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHEB itself. We selected most functions RHEB had, and list some proteins which have the same functions with RHEB. You can find most of the proteins on our site.
|GTP binding||C9orf86; KRAS; MFN2; RAB31; RAB1BA; RAB3B; HRASB; EIF5; RAB9B; EHD2|
|GTPase activity||GNB3; RALAA; MX1; GNAT3; EEF1A1L1; RAB35B; ARHGDIB; TUBA8L; RAB2B; RAB1B|
|metal ion binding||PDLIM5A; DPEP2; NGB; TRIM3B; SMYD1B; SPRTN; OSGEP; AMPD1; CYP2K22; NEURL1B|
|protein binding||TRPV4; NEUROD1; TCF12; MYOT; KEAP1; AP1M2; COG5; POLI; RBPJ; LNX1|
|protein kinase binding||CD24; IBTK; TTN; DNM1; JAK2; CDK5; CDK5RAP3; PPP1R12B; TCTN2; TPX2|
RHEB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHEB here. Most of them are supplied by our site. Hope this information will be useful for your research of RHEB.
RAF1; EIF1B; MTOR; TRAF2; RPTOR; CREB3; ARIH2; A2M; NCAM1; Traf2; PSEN2; Appl1; Blzf1; ECSIT; pi3p