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Official Full Name Ras homolog enriched in brain
Background Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins that was originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other Ras family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies suggest that Rheb plays an important role in regulating the insulin/mTOR signaling pathway.
Synonyms RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RHEB-001HCL Recombinant Human RHEB cell lysate Insect Cell N/A
    Human RHEB-1144H Recombinant Human Ras Homolog Enriched In Brain, GST-tagged E.coli GST
    Human RHEB-1181H Recombinant Human RHEB Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human RHEB-2289H Recombinant Human RHEB, His-tagged E.coli His
    Human RHEB-31324TH Recombinant Human RHEB, His-tagged His
    Human RHEB-31325TH Recombinant Human RHEB, T7 -tagged T7
    Human RHEB-31326TH Recombinant Human RHEB E.coli N/A
    Human RHEB-384H Recombinant Human Ras Homolog Enriched In Brain, His-tagged Sf9 Insect Cell His
    Human RHEB-393H Recombinant Human Ras Homolog Enriched in Brain, T7-Tagged E.coli His
    Human RHEB-521H Recombinant Human RHEB, His tagged Insect Cell His
    Human RHEB-5588H Recombinant Human RHEB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Rheb-5504M Recombinant Mouse Rheb Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat RHEB-5032R Recombinant Rat RHEB Protein Mammalian Cell His
    Rhesus Macaque RHEB-3884R Recombinant Rhesus monkey RHEB Protein, His-tagged Mammalian Cell His
    Zebrafish RHEB-4581Z Recombinant Zebrafish RHEB Mammalian Cell His

    RHEB involved in several pathways and played different roles in them. We selected most pathways RHEB participated on our site, such as Phospholipase D signaling pathway, mTOR signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHEB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway LPAR4; PLCG1; IL-8; DGKD; PLCB3; INS2; RHOA; PTK2B; PLA2G4A; PPAP2C
    mTOR signaling pathway PRKCBB; IRS1; PDPK1B; RRN3; PIK3R3B; PIK3R3; RPS6KA3; PRR5; RPS6KAL; BRAF
    PIK-Akt signaling pathway FGF9; IBSP; CCNE1; HSP90AB1; CREB3L1; IFNB1; PPP2R2D; FGF4; FLT1; MAPK3
    AMPK signaling pathway CAB39L; PPP2R5E; CREB3L2; FASN; PCK1; PRKAA1; CPT1C; CFTR; SCD5; PRKAB1
    Insulin signaling pathway HRASA; PHKG1A; G6PC3; PPP1R3CA; PRKAA2; PKLR; FBP1B; GYS2; IKBKB; CALM2B
    Thyroid hormone signaling pathway CASP9; ATP1B4; PFKP; MED13L; RCAN2; CCND1; NRAS; PLCB2; NCOA1; PIK3CG
    Choline metabolism in cancer PDGFB; PIK3R5; MAPK10; HIF1A; MAP2K2; RPS6KB1; RALGDS; PIK3CB; RAC3; PIK3R1

    RHEB has several biochemical functions, for example, GTP binding, GTPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RHEB itself. We selected most functions RHEB had, and list some proteins which have the same functions with RHEB. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activity MXG; GNAI2; TUBD1; RAB5B; EIF5; GNAQ; GNG5; RAB5AB; TUBA8L2; ARFRP1
    metal ion binding ERMP1; PDE1B; PDE5AB; ARID2; SEMG1; RAD50; ARAP3; PON2; POLR2B; ZNF550
    protein binding PLK3; GPR177; GIPC2; FAM81B; COX4I1; PMP22; MITF; HIST1H3A; PEF1; ZNF177
    protein kinase binding NBEA; EEF1A1; RHOD; PTPN23; CEP152; DLG1L; ATG13; FGR; FER; PLK1S1

    RHEB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHEB here. Most of them are supplied by our site. Hope this information will be useful for your research of RHEB.

    RAF1; EIF1B; MTOR; TRAF2; RPTOR; CREB3; ARIH2; A2M; NCAM1; Traf2; PSEN2; Appl1; Blzf1; ECSIT; pi3p

    Jeon, MT; Nam, JH; et al. In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production. MOLECULAR THERAPY 23:445-455(2015).
    Wu, D; Chapman, JR; et al. Intestinal Cell Kinase (ICK) Promotes Activation of mTOR Complex 1 (mTORC1) through Phosphorylation of Raptor Thr-908. JOURNAL OF BIOLOGICAL CHEMISTRY 287:12510-12519(2012).

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