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Recombinant Full Legnth Human RHEB, His-tagged

Cat.No. : RHEB-2289H
Product Overview : Recombinant Human RHEB protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Availability February 11, 2025
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Source : E.coli
Species : Human
Tag : His
Protein length : 1-184aa
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : RHEB Ras homolog enriched in brain [ Homo sapiens ]
Official Symbol : RHEB
Synonyms : RHEB; Ras homolog enriched in brain; Ras homolog enriched in brain 2 , RHEB2; GTP-binding protein Rheb; Ras homolog enriched in brain 2; RHEB2; MGC111559;
Gene ID : 6009
mRNA Refseq : NM_005614
Protein Refseq : NP_005605
MIM : 601293
UniProt ID : Q15382
Chromosome Location : 7q36
Pathway : Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; Insulin receptor signalli
Function : GTP binding; GTPase activity; metal ion binding; nucleotide binding;

Not For Human Consumption!

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03/07/2020

    Researchers using RHEB protein can benefit from its high purity and quality, ensuring reliable results.

    05/24/2018

      the RHEB protein is available in different formats, including recombinant and purified variants.

      11/13/2017

        This flexibility allows researchers to select the most suitable form for their particular experimental setup, enhancing the efficiency and accuracy of their trials.

        Q&As (5)

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        How does RHEB interact with the mTOR pathway, and what implications does this have for clinical interventions 05/29/2021

        RHEB directly interacts with the mTOR pathway, a key regulator of cell growth. Understanding this interaction provides insights for developing drugs that target this pathway in diseases like cancer.

        Are there any experimental drugs targeting RHEB currently in development? 01/15/2020

        Some experimental drugs targeting RHEB are in preclinical development, showing promise in modulating cell growth and survival.

        In what ways can the clinical application of RHEB be explored in cancer treatment? 04/24/2018

        RHEB's involvement in cell growth makes it a potential target for cancer therapy. Understanding its role may lead to the development of targeted therapies.

        Are there any ongoing clinical trials involving RHEB protein in cancer research? 02/18/2018

        Research is underway to evaluate the therapeutic potential of targeting RHEB in cancer treatment, with several clinical trials exploring its role as a therapeutic target.

        How does the dysregulation of RHEB contribute to diseases? 04/23/2017

        Dysregulation of RHEB is associated with various diseases, including cancer and neurological disorders, due to its impact on cell growth and survival pathways.

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