RORC

  • Official Full Name

    RAR-related orphan receptor C

  • Overview

    The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    RORC; RAR-related orphan receptor C; TOR; RORG; RZRG; NR1F3; RZR-GAMMA; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RAR-related orphan receptor C, isoform a; RAR-related orphan nuclear receptor variant 2; nuclear receptor subfamily 1 group F member 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Flag
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RORC-114H Recombinant Human RORC Protein, GST-tagged Insect cell GST
Human RORC-02H Recombinant Human RORC Protein, GST-tagged Insect Cell GST
Human RORC-18H Recombinant Human RORC protein, GST-tagged Wheat Germ GST
Human RORC-15H Recombinant Human RORC protein, His/Flag-tagged E.coli His/Flag
Human RORC-622H Recombinant Human RORC Mammalian Cell His
Human RORC-16H Recombinant Human RORC protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RORC-17H Recombinant Human RORC protein, GST-tagged Wheat Germ GST
Human RORC-1084H Recombinant Human RORC protein, His-tagged E.coli His Glu212~Ser461
Human RORC-1357H Recombinant Human RORC Protein, His-SUMO-tagged E.coli His/SUMO
Human RORC-2244HCL Recombinant Human RORC 293 Cell Lysate HEK293 N/A
Human RORC-2245HCL Recombinant Human RORC 293 Cell Lysate HEK293 N/A
Human RORC-5473H Recombinant Human RORC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RORC-4796HFL Recombinant Full Length Human RORC protein, Flag-tagged Mamanlian cells Flag
Human RORC-4002H-B Recombinant Human RORC Protein Pre-coupled Magnetic Beads HEK293
Human RORC-5893H Recombinant Human RORC protein, His-tagged E.coli His 165-518 aa
Human RORC-631HF Recombinant Full Length Human RORC Protein, GST-tagged In Vitro Cell Free System GST 518 amino acids
Human RORC-4002H Recombinant Human RORC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RORC-6192H Recombinant Human RORC Protein (Leu241-Phe486), N-His tagged E.coli N-His Leu241-Phe486
Human RORC-6193H Recombinant Human RORC Protein (Glu212-Ser461), His tagged E.coli His Glu212-Ser461
Human RORC-6194H Recombinant Human RORC Protein (Thr268-Phe494), N-His and N-SUMO tagged E.coli N-His and N-SUMO Thr268-Phe494
Mouse RORC-14381M Recombinant Mouse RORC Protein Mammalian Cell His
Mouse RORC-7708M Recombinant Mouse RORC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RORC-2011M Recombinant Mouse RORC Protein (1-516 aa), His-tagged Yeast His 1-516 aa
Mouse Rorc-2027M Recombinant Mouse Rorc Protein, His-tagged E.coli N-His Asp267-Lys516
Mouse Rorc-5576M Recombinant Mouse Rorc Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RORC-7708M-B Recombinant Mouse RORC Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RORC Related Signal Pathway

RORC involved in several pathways and played different roles in them. We selected most pathways RORC participated on our site, such as Circadian rhythm, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Circadian rhythmRORB;BTRC;CRY1;RORC;PRKAA1;PRKAG2;PRKAA2;CLOCK;FBXW11
Inflammatory bowel disease (IBD)GATA3;RORA;HLA-DPB1;IL18RAP;H2-AB1;HLA-DMA;IL4R;STAT6;IL1A

RORC has several biochemical functions, for example, DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, oxysterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORC itself. We selected most functions RORC had, and list some proteins which have the same functions with RORC. You can find most of the proteins on our site.

Function Related Protein
DNA bindingYBX1;POLR2EB;ZNF473;ZNF530;EEPD1;NKX6.3;SOX21B;GIN1;TAF11
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingNR1D2;PPARG;NR5A2;PPARAB;RORAB;NR2F1;NR5A1B;PPARDB;RXRA
oxysterol bindingRORC;OSBP;RORA;OSBPL5;GPR183
protein bindingGPR158;LRRC4C;CALM3;GNG5;FBXW7;MAPRE3;THAP11;EXO1;ARID5A
sequence-specific DNA bindingNR4A2A;ATF4;FOXI3B;NFE2L1A;TCF7L2;PPARA;NKX6-1;TCF7L1A;NKX2.2A
steroid hormone receptor activityTHRA;RORC;ESRRB;NR2F2;PPARAB;NR2F5;NR6A1B;RARB;RARGA
transcription factor activity, direct ligand regulated sequence-specific DNA bindingRORA;RORC
transcription factor activity, sequence-specific DNA bindingPHF1;ZNF649;EOMESA;TAL1;SMAD7;NPAS1;HOXC8A;PAX8;ZNF189
zinc ion bindingZNF184;TRIM2;MMP16;LIMK1A;NRD1B;DRP2;AEBP1;P2RX4;ZCCHC16

RORC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORC here. Most of them are supplied by our site. Hope this information will be useful for your research of RORC.

Clock; Arntl; NCOA1; CREBBP; PPARGC1A; 20-hydroxycholesterol; 25-hydroxycholestero; (22r)-22-hydroxycholesterol; BHLHE40; Per2; EVI2A; PPP2R1A; PPP2R1B; PPP1CC; PPP1CA; PPP1CB; PPP2CA

Research Area

Related articles

Lubberts, E; et al. Role of T Lymphocytes in the Development of Rheumatoid Arthritis. Implications for Treatment. CURRENT PHARMACEUTICAL DESIGN 21:142-146(2015).
Balabko, L; Andreev, K; et al. Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror gamma T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. SCIENTIFIC REPORTS 4:-(2014).
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