• Official Full Name

    ribosomal protein L7a

  • Background

    Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
  • Synonyms

    RPL7A; ribosomal protein L7a; 60S ribosomal protein L7a; L7A; PLA X polypeptide; SURF3; surfeit 3; surfeit locus protein 3; thyroid hormone receptor uncoupling protein; TRUP; MGC103146; PLA-X polypeptide; RL7A_HUMAN; RP23-414L19.4; SURF 3; OTTHUMP00000022469;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST|His
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken RPL7A-1198C Recombinant Chicken RPL7A Mammalian Cell His
    Cynomolgus Monkey RPL7A-626C Recombinant Cynomolgus Monkey RPL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey RPL7A-626C-B Recombinant Cynomolgus Monkey RPL7A Protein Pre-coupled Magnetic Beads HEK293
    Cynomolgus Monkey RPL7A-883C Recombinant Cynomolgus RPL7A Protein, His-tagged Mammalian Cell His
    Human RPL7A-663H Recombinant Human ribosomal protein L7a, His-tagged E.coli His
    Human RPL7A-689H Recombinant Human RPL7A Protein, GST-His-tagged E.coli GST/His
    Human RPL7A-2189HCL Recombinant Human RPL7A 293 Cell Lysate HEK293 N/A
    Human RPL7A-31337TH Recombinant Human RPL7A, His-tagged E.coli His
    Mouse RPL7A-7752M-B Recombinant Mouse RPL7A Protein Pre-coupled Magnetic Beads HEK293
    Mouse RPL7A-7752M Recombinant Mouse RPL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse RPL7A-14448M Recombinant Mouse RPL7A Protein Mammalian Cell His
    Rhesus Macaque RPL7A-3811R-B Recombinant Rhesus Macaque RPL7A Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque RPL7A-3811R Recombinant Rhesus Macaque RPL7A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque RPL7A-3994R Recombinant Rhesus monkey RPL7A Protein, His-tagged Mammalian Cell His
    Zebrafish RPL7A-10402Z Recombinant Zebrafish RPL7A Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    RPL7A involved in several pathways and played different roles in them. We selected most pathways RPL7A participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPL7A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    RPL7A has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPL7A itself. We selected most functions RPL7A had, and list some proteins which have the same functions with RPL7A. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA bindingTPD52L2;BCLAF1;WBP11;C3orf26;RPL22;EIF3G;FRG1;HIST1H4D;FAM46A
    protein bindingC19orf46;BCL2L16;SLC6A18;DPH3;TLE1;PSMG2;PRKAR1A;PTPN6;PABPC1
    structural constituent of ribosomeMRPL47;RPLP0;RPL38;MRPL42;MRPS22;MRPL21;RPLP1;RPL14;MRPS31

    RPL7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPL7A here. Most of them are supplied by our site. Hope this information will be useful for your research of RPL7A.

    STAU1; ESR1; ESR2; ACTB; NFKB2; MAP3K14; SOCS3; CTBP2; GRINL1A; CCDC47; MKNK2; ERG; midostaurin; ssrna_ug

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