RPS6KB2

  • Official Full Name

    ribosomal protein S6 kinase, 70kDa, polypeptide 2

  • Overview

    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
  • Synonyms

    RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; ribosomal protein S6 kinase, 70kD, polypeptide 2; ribosomal protein S6 kinase beta-2; KLS; P70 BETA; p70S6Kb; STK14B; P70S6K2; S6K-beta; p70 S6KB; p70-S6K 2; S6K-beta-2; p70 S6K-beta; p70 S6 kina;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KB2-360H Recombinant Human RPS6KB2 protein, His/MBP-tagged E.coli His/MBP 211-347 aa
Human RPS6KB2-377H Recombinant Human RPS6KB2, GST-tagged, Active Sf9 Insect Cell GST
Human RPS6KB2-2437H Recombinant Human RPS6KB2, His-tagged E.coli His 1-325aa
Human RPS6KB2-2158HCL Recombinant Human RPS6KB2 293 Cell Lysate HEK293 N/A
Human RPS6KB2-3112H Recombinant Human RPS6KB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPS6KB2-5193H Recombinant Human RPS6KB2 protein, GST-tagged E.coli GST 1-210aa
Human RPS6KB2-18H Recombinant Active Human RPS6KB2 (C150T) Protein (Full length), N-GST-tagged Sf9 insect cells N-GST Full length
Human RPS6KB2-1988HFL Recombinant Full Length Human RPS6KB2 Protein, C-Flag-tagged Mammalian cells Flag
Human RPS6KB2-4909HF Active Recombinant Full Length Human RPS6KB2 Protein, GST-tagged Insect (sf21) GST 1-482(end)
Human RPS6KB2-1916H Recombinant Human RPS6KB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPS6KB2-6202H Recombinant Human RPS6KB2 Protein (Asp194-Pro453), N-His tagged E.coli N-His Asp194-Pro453
Human RPS6KB2-1935H Recombinant Human RPS6KB2 protein, His & GST-tagged E.coli His/GST Asp194~Pro453 (Accession # Q9UBS0)
Human RPS6KB2-1916H-B Recombinant Human RPS6KB2 Protein Pre-coupled Magnetic Beads HEK293
Human CPBT-Y0065RH Rabbit Anti-Human p70 S6 Kinase (S6K) Polyclonal Antibody Rabbit N/A
Mouse RPS6KB2-14500M Recombinant Mouse RPS6KB2 Protein Mammalian Cell His
Mouse RPS6KB2-7795M Recombinant Mouse RPS6KB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RPS6KB2-7795M-B Recombinant Mouse RPS6KB2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rps6kb2-5614M Recombinant Mouse Rps6kb2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RPS6KB2 Related Signal Pathway

RPS6KB2 involved in several pathways and played different roles in them. We selected most pathways RPS6KB2 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayCAMK2B1;HRAS;AKT2;EGFRA;NCK1;PAK2;CAMK2B;CAMK2D2;PAK6
HIF- signaling pathwayEGLN1;TF;NPPA;TFRC;PIK3CD;IFNGR1;NFKB1;MKNK2;GM5506
mTOR signaling pathwayIGF1;INSB;PRKCB;TNF;PIK3R3;AKT1;PTEN;PRKCBA;PRKCBB
PIK-Akt signaling pathwayLPAR3;PPP2R3A;PCK1;THBS1;PCK2;PDPK1;EPO;Fgf15;MCL1
AMPK signaling pathwayADIPOR1;CPT1A;PFKFB2;AKT2;SREBF1;PRKAG2;PRKAB1;PIK3R1;ADIPOQ
TGF-beta signaling pathwaySKP1;GDF6;ID2A;INHBB;NOG3;TGFBR2;ACVR2A;ID3;BMP4
Fc gamma R-mediated phagocytosisARPC1A;FCGR3A;PIK3R3;BIN1;RAC1;RPS6KB1;LIMK1;PLD2;PIK3CD
Insulin signaling pathwayPHKB;PPP1R3A;KRAS;PRKAB1B;INS;FBP2;PDPK1B;FLOT1B;PRKCI
Insulin resistanceNFKBIAA;MAPK8B;SLC27A1A;TNF;OGT;MAPK8;CREB3L3L;PRKAB1A;CREB1A
Proteoglycans in cancerTWIST2;TIMP3;WNT9A;WNT2;PLCG1;FASLG;IL12B;SLC9A1;WNT11
Acute myeloid leukemiaEIF4EBP1;NFKB1;PIK3R3;SOS1;GRB2;IKBKB;AKT3;BAD;PIK3CA
Choline metabolism in cancerSLC22A2;PIK3R3;PDPK1;RHEB;SOS1;PLA2G4A;PPAP2C;TSC1;MTOR

RPS6KB2 has several biochemical functions, for example, ATP binding, peptide binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB2 itself. We selected most functions RPS6KB2 had, and list some proteins which have the same functions with RPS6KB2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP2C1;CKMT2B;LATS1;PPP1CA;GK2;ACSS3;TTLL9;DDX50;MYLK
peptide bindingH2-Q10;Ctsl;QRFPR;Npepo;BDKRB1;CRIP1;ANPEP;IDE;LNPEP
protein kinase activityRPS6KA6;NLK;TSSK1;RIPK4;SOX9;FASTKD3;CDK17;MAP3K14;NIM1
protein serine/threonine kinase activityRIPK2;CSNK1G2B;CLK1;LMTK2;TRIO;MAP3K10;GM4922;MAP2K1;CLK3
ribosomal protein S6 kinase activityALPK2;RPS6KB1B;RPS6KA2;RPS6KA6;RPS6KB1;RPS6KA1;RPS6KA3B;RPS6KA3;RPS6KB2

RPS6KB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB2.

RPS6; CSNK2B; SRPK1; COASY; ATP5A1; MAPK8IP2; SNW1; CDC5L; EEF2K

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