Recombinant Human RUNX2 Protein

• Cat.No.: RUNX2-6644H
• Product Overview: Recombinant human RUNX2 protein without tag was expressed in E. coli.

Specification

• Description: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1 (I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.
• Source: E. coli
• Species: Human
• Tag: Tag Free
• Form: Lyophilized powder/frozen liquid
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: RUNX2 runt-related transcription factor 2 [ Homo sapiens (human) ]
• Official Symbol: RUNX2
• Synonyms: RUNX2; runt-related transcription factor 2; CBFA1, CCD, CCD1; AML3; PEBP2A1; PEBP2aA1; CBF-alpha-1; PEA2-alpha A; PEBP2-alpha A; oncogene AML-3; acute myeloid leukemia 3 protein; SL3-3 enhancer factor 1 alpha A subunit; osteoblast-specific transcription factor 2; SL3/AKV core-binding factor alpha A subunit; core-binding factor, runt domain, alpha subunit 1; polyomavirus enhancer-binding protein 2 alpha A subunit; CCD; CCD1; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2A2; PEBP2aA; MGC120022; MGC120023
• Gene ID: 860
• mRNA Refseq: NM_001015051
• Protein Refseq: NP_001015051
• MIM: 600211
• UniProt ID: Q13950