Recombinant Human RUNX2 protein, His-tagged RUNX2-48H

Recombinant Human RUNX2 protein, His-tagged


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Recombinant Human RUNX2 protein, His-tagged

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Cat.No. : RUNX2-48H
Product Overview : Recombinant Human RUNX2, transcript variant 3, fused with His tag at N-terminal was expressed in E. coli.
Description : This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Source : E. coli
Species : Human
Tag : His
Form : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
Molecular Mass : 54.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : RUNX2 runt-related transcription factor 2 [ Homo sapiens ]
Official Symbol : RUNX2
Synonyms : RUNX2; runt-related transcription factor 2; CBFA1, CCD, CCD1; AML3; PEBP2A1; PEBP2aA1; CBF-alpha-1; PEA2-alpha A; PEBP2-alpha A; oncogene AML-3; acute myeloid leukemia 3 protein; SL3-3 enhancer factor 1 alpha A subunit; osteoblast-specific transcription factor 2; SL3/AKV core-binding factor alpha A subunit; core-binding factor, runt domain, alpha subunit 1; polyomavirus enhancer-binding protein 2 alpha A subunit; CCD; CCD1; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2A2; PEBP2aA; MGC120022; MGC120023;
Gene ID : 860
mRNA Refseq : NM_001015051
Protein Refseq : NP_001015051
MIM : 600211
UniProt ID : Q13950
Chromosome Location : 6p21
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem;
Function : ATP binding; DNA binding; protein binding; sequence-specific DNA binding transcription factor activity;

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