S100A4

  • Official Full Name

    S100 calcium binding protein A4

  • Overview

    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    S100A4; S100 calcium binding protein A4; 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98; protein S100-A4; protein Mts1; fibroblast-specific protein-1; placental calcium-binding protein; malignant transformation suppression 1; leukemia multidrug resistance associated protein; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • hFc
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human S100A4-201H Recombinant Human S100 Calcium Binding Protein A4 E.coli N/A
Human S100A4-70H Recombinant Human S100A4 protein, hFc-tagged HEK293 hFc
Human S100A4-89H Recombinant Human S100A4 E.coli N/A
Human S100A4-409H Recombinant Human S100 Calcium Bbinding Protein A4, His-tagged E.coli His
Human S100A4-3727H Recombinant Human S100A4, His-tagged E.coli His
Human S100A4-2489H Recombinant Human S100A4, GST-tagged E.coli GST
Human S100A4-31367TH Recombinant Human S100A4 E.coli N/A
Human S100A4-162H Recombinant Human S100A4 Mammalian Cell His
Human S100A4-195H Recombinant Human S100A4 protein, His-tagged E.coli His
Human S100A4-2859HCL Recombinant Human S100A4 cell lysate Human Cell N/A
Human S100A4-3461H Recombinant Human S100A4 protein, His-SUMO-tagged E.coli His-SUMO
Human S100A4-4590H Recombinant Human S100A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human S100A4-385H Recombinant Human S100A4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human S100A4-1940H-B Recombinant Human S100A4 Protein Pre-coupled Magnetic Beads HEK293
Human S100A4-1051HFL Recombinant Full Length Human S100A4 Protein, C-Flag-tagged Mammalian cells Flag
Human S100A4-6215H Recombinant Human S100A4 Protein (Met1-Lys101), N-His tagged E.coli N-His
Human S100A4-1940H Recombinant Human S100A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse S100A4-159M Recombinant Mouse S100a4, Fc tagged Human Cell His
Mouse S100a4-532M Recombinant Mouse S100a4 Human Cell N/A
Mouse S100a4-3542M Recombinant Mouse S100a4, His-tagged E.coli His
Mouse S100a4-533M Recombinant Mouse S100a4 protein, His-tagged E.coli His
Mouse S100a4-5105M Recombinant Mouse S100 calcium Binding Protein A4, His-tagged Mouse His
Mouse S100A4-001MCL Recombinant Mouse S100A4 cell lysate Human Cell N/A
Mouse S100a4-5669M Recombinant Mouse S100a4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse S100a4-566M Recombinant Mouse S100a4 Protein, hFc-tagged HEK293 hFc
Mouse S100a4-7323M Recombinant Mouse S100a4 Protein, His-tagged E.coli His
Rat S100A4-5213R Recombinant Rat S100A4 Protein Mammalian Cell His
Rat S100A4-4872R Recombinant Rat S100A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat S100A4-2599R Recombinant Rat S100A4 Protein (2-101 aa), His-Myc-tagged E.coli His/Myc
Rat S100A4-4872R-B Recombinant Rat S100A4 Protein Pre-coupled Magnetic Beads HEK293
Cattle S100A4-2120C Recombinant Cattle S100A4 protein, His-tagged E.coli His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • S100A4 Related Articles
  • S100A4 Related Research Area

S100A4 involved in several pathways and played different roles in them. We selected most pathways S100A4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

S100A4 has several biochemical functions, for example, RAGE receptor binding, actin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A4 itself. We selected most functions S100A4 had, and list some proteins which have the same functions with S100A4. You can find most of the proteins on our site.

Function Related Protein
RAGE receptor bindingHMGB2;S100B;S100A9;S100P;S100A8;S100A13;S100A7;FPR1;HMGB1
actin bindingKPTN;CAPGB;HIP1R;ABLIM1A;CORO1A;EPB41L2;MSRB1A;SHROOM3;CNN3B
calcium ion bindingPRRG4;CAPSL;TTN;TNNC1A;S100G;IHH;PPP3CA;MYL7;NUCB2B
calcium-dependent protein bindingANXA6;STMN2;VAMP2;PDCD6IP;MBL2;SELP;SLC9A1;RBM22;TNNI3
identical protein bindingCLDN2;SNX16;BNIP2;TMEM173;IGF2R;IAPP;CBY1;LUC7L;PKD2L1
poly(A) RNA bindingYWHAZ;CLNS1A;RBM12B;NAP1L4;NUSAP1;MTERF;RPL13;TRIM28;PKN2
protein bindingCCDC53;MYOT;RNF135;HIST3H3;PPIAL4A;SEC23B;CACNA2D1A;HOXC4;KPNB1

S100A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A4.

TP53; S100B; MDM2; AREGB; BTC

Grum-Schwensen, B; Klingelhofer, J; et al. S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance. BMC CANCER 15:-(2015).
Wang, DG; Zhang, JW; et al. Functional expression, characterization and application of the human S100A4 protein. MOLECULAR MEDICINE REPORTS 11:175-181(2015).
  • Q&As
  • Reviews

Q&As (6)

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What is the current progress in drug development for S100A4? 04/28/2022

Drug development for S100A4 is currently in clinical trials, including small molecule inhibitors against S100A4 and inhibitors against the S100A4 signaling pathway.

Is the expression of S100A4 affected by environmental factors? 11/08/2021

Yes, the expression of S100A4 is affected by environmental factors, such as nutritional status, inflammation level, etc.

What role does S100A4 play in tumor immunotherapy? 08/10/2021

S100A4 plays an important role in tumor immunotherapy, it can act as a tumor-associated antigen, activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

How to improve the nutritional status of S100A4 protein through diet? 02/19/2021

There is no conclusive evidence that diet improves the nutritional status of S100A4 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.

How can S100A4 be used as a biomarker in clinical practice? 01/22/2020

In clinical practice, the expression level of S100A4 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of oncological diseases.

What is the relationship between S100A4 protein and muscle wasting? 12/31/2019

Studies have shown that S100A4 protein can inhibit the occurrence of muscle wasting, but the specific mechanism is not clear.

Customer Reviews (3)

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Reviews
10/07/2022

    I have been using these for several years and they have been very stable and I swear by this product.

    04/14/2022

      The experimental process is simple and there is no special environmental requirement.

      11/20/2021

        It can remain stable under different temperature and pH conditions.

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