S100A4
-
Official Full Name
S100 calcium binding protein A4
-
Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
S100A4; S100 calcium binding protein A4; 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98; protein S100-A4; protein Mts1; fibroblast-specific protein-1; placental calcium-binding protein; malignant transformation suppression 1; leukemia multidrug resistance associated protein; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- C
- Myc
- DDK
- Flag
- GST
- hFc
- His
- His (Fc)
- Avi
- His|Myc
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- S100A4 Related Articles
- S100A4 Related Research Area
S100A4 involved in several pathways and played different roles in them. We selected most pathways S100A4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|
S100A4 has several biochemical functions, for example, RAGE receptor binding, actin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A4 itself. We selected most functions S100A4 had, and list some proteins which have the same functions with S100A4. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
RAGE receptor binding | S100A12;S100B;FPR1;S100A13;S100A7;S100A4;S100A8;S100A9;HMGB2 |
actin binding | TAGLN;EPB41L3A;ANTXR2A;HPCA;SPIRE1A;PHACTR3A;SNTB1;EPS8L1;CLMN |
calcium ion binding | DMP1;PCDH10A;ITGB1BP2;AOC3;PCDH2AB8;PCDH18B;S100A7A;FAT2;CALR |
calcium-dependent protein binding | CALM2;S100A6;RAC3;SNAP25;SLC9A1;CHP;C9orf9;TSG101;STMN2 |
identical protein binding | GBP5;PYDC3;CLDND;PSME3;SMAD1;DIAP1;MVK;ZNF703;HSPB8 |
poly(A) RNA binding | GRWD1;PABPN1;AGO3;DDX3X;NCBP1;FAM103A1;ELAVL2;RRP7A;LLPH |
protein binding | ZAP70;ORAI1;SLC1A2;TRAPPC4;LMNA;TNIP1;MAB21L1;KRT6A;ATP6V1D |
S100A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A4.
TP53; S100B; MDM2; AREGB; BTC
- Q&As
- Reviews
Q&As (6)
Ask a questionDrug development for S100A4 is currently in clinical trials, including small molecule inhibitors against S100A4 and inhibitors against the S100A4 signaling pathway.
Yes, the expression of S100A4 is affected by environmental factors, such as nutritional status, inflammation level, etc.
S100A4 plays an important role in tumor immunotherapy, it can act as a tumor-associated antigen, activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
There is no conclusive evidence that diet improves the nutritional status of S100A4 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.
In clinical practice, the expression level of S100A4 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of oncological diseases.
Studies have shown that S100A4 protein can inhibit the occurrence of muscle wasting, but the specific mechanism is not clear.
Customer Reviews (3)
Write a reviewI have been using these for several years and they have been very stable and I swear by this product.
The experimental process is simple and there is no special environmental requirement.
It can remain stable under different temperature and pH conditions.
Ask a Question for All S100A4 Products
Required fields are marked with *
My Review for All S100A4 Products
Required fields are marked with *