Recombinant Mouse S100 calcium Binding Protein A4, His-tagged

• Cat.No.: S100a4-5105M
• Product Overview: Recombinant mouseS100a4 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.

Specification

• Cat. No.: S100a4-5105M
• Description: S100a4 belongs tothe S100 super-family of proteins containing 2 EF-hand calcium bindingdomains. This protein is ubiquitously overexpressed and is localized in thecytoplasm and/or nucleus. S100a4 may play a role in motility, invasion, andtubulin polymerization. Chromosomal rearrangements and altered expression ofthe S100a4 have been implicated in tumor metastasis.
• Concentration: 1 mg/ml
• Source: Mouse
• Host: E.coli
• Form: Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 2mM DTTand 0.1M NaCl.
• Purity: > 90% by SDS -PAGE
• Sequence: 1-101 amino acids:MGSSHHHHHH SSGLVPRGSH MARPLEEALD VIVSTFHKYS GKEGDKFKLN KTELKELLTR ELPSFLGKRTDEAAFQKVMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK K
• Molecular Mass: 13.9 kDa(121aa), confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: S100a4

Gene Information

• Gene Name: S100a4 S100 calcium bindingprotein A4 [ Mus musculus ]
• Synonyms: S100a4;S100 calcium binding protein A4; 42a; 18A2; Capl;FSp1; Mts1; pk9a; PeL98; metastasin; protein S100-A4; calvasculin; protein18A2; protein Mts1; metastatic cell protein; S100 calcium-binding protein A4;placental calcium-binding protein; Protein S100-A4; Metastasin; Metastatic cell protein; PEL98; Placentalcalcium-binding protein; Protein 18A2; Protein Mts1
• Gene ID: 20198
• mRNA Refseq: NM_011311
• Protein Refseq: NP_035441
• UniProt ID: P07091
• Chromosome Location: 39.27 cM
• Function: RAGE receptorbinding; calcium ion binding; calcium-dependent protein binding; identicalprotein binding; protein binding

Reviews

10/07/2022

I have been using these for several years and they have been very stable and I swear by this product.

04/14/2022

The experimental process is simple and there is no special environmental requirement.

11/20/2021

It can remain stable under different temperature and pH conditions.

Q&As

What is the current progress in drug development for S100A4?

Drug development for S100A4 is currently in clinical trials, including small molecule inhibitors against S100A4 and inhibitors against the S100A4 signaling pathway.

Is the expression of S100A4 affected by environmental factors?

Yes, the expression of S100A4 is affected by environmental factors, such as nutritional status, inflammation level, etc.

What role does S100A4 play in tumor immunotherapy?

S100A4 plays an important role in tumor immunotherapy, it can act as a tumor-associated antigen, activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

How to improve the nutritional status of S100A4 protein through diet?

There is no conclusive evidence that diet improves the nutritional status of S100A4 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.

How can S100A4 be used as a biomarker in clinical practice?

In clinical practice, the expression level of S100A4 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of oncological diseases.

What is the relationship between S100A4 protein and muscle wasting?

Studies have shown that S100A4 protein can inhibit the occurrence of muscle wasting, but the specific mechanism is not clear.