Recombinant Human S100A4 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: S100A4-385H
• Product Overview: S100A4 MS Standard C13 and N15-labeled recombinant protein (NP_002952) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 11.7 kDa
• AA Sequence: MACPLEKALDVMVSTFHKYSGKEGD KFKLNKSELKELLTRELPSFLGKRT DEAAFQKLMSNLDSNRDNEVDFQEY CVFLSCIAMMCNEFFEGFPDKQPRK KTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: S100A4 S100 calcium binding protein A4 [ Homo sapiens (human) ]
• Official Symbol: S100A4
• Synonyms: S100A4; S100 calcium binding protein A4; CAPL, MTS1, S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); protein S100-A4; 18A2; 42A; fibroblast specific protein 1; FSP1; P9KA; PEL98; protein Mts1; fibroblast-specific protein-1; placental calcium-binding protein; malignant transformation suppression 1; leukemia multidrug resistance associated protein; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog); CAPL; MTS1
• Gene ID: 6275
• mRNA Refseq: NM_002961
• Protein Refseq: NP_002952
• MIM: 114210
• UniProt ID: P26447

Reviews

10/07/2022

I have been using these for several years and they have been very stable and I swear by this product.

04/14/2022

The experimental process is simple and there is no special environmental requirement.

11/20/2021

It can remain stable under different temperature and pH conditions.

Q&As

What is the current progress in drug development for S100A4?

Drug development for S100A4 is currently in clinical trials, including small molecule inhibitors against S100A4 and inhibitors against the S100A4 signaling pathway.

Is the expression of S100A4 affected by environmental factors?

Yes, the expression of S100A4 is affected by environmental factors, such as nutritional status, inflammation level, etc.

What role does S100A4 play in tumor immunotherapy?

S100A4 plays an important role in tumor immunotherapy, it can act as a tumor-associated antigen, activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

How to improve the nutritional status of S100A4 protein through diet?

There is no conclusive evidence that diet improves the nutritional status of S100A4 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.

How can S100A4 be used as a biomarker in clinical practice?

In clinical practice, the expression level of S100A4 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of oncological diseases.

What is the relationship between S100A4 protein and muscle wasting?

Studies have shown that S100A4 protein can inhibit the occurrence of muscle wasting, but the specific mechanism is not clear.