S1PR5

  • Official Full Name

    sphingosine-1-phosphate receptor 5

  • Overview

    The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.
  • Synonyms

    S1PR5; sphingosine-1-phosphate receptor 5; EDG8, endothelial differentiation, sphingolipid G protein coupled receptor, 8; sphingosine 1-phosphate receptor 5; Edg 8; S1P receptor 5; S1P receptor Edg-8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human S1PR5-4043H Recombinant Human S1PR5 Protein, GST-tagged Wheat Germ GST
Human S1PR5-2496H Recombinant Human S1PR5, GST-tagged E.coli GST 213-398aa
Human S1PR5-2082HCL Recombinant Human S1PR5 293 Cell Lysate HEK293 N/A
Human S1PR5-2154H Recombinant Human S1PR5 Full Length Transmembrane protein(VLPs) HEK293 N/A Met 1 - Asp 398
Human S1PR5-4743HF Recombinant Full Length Human S1PR5 Protein, GST-tagged In Vitro Cell Free System GST 398 amino acids
Mouse S1PR5-14632M Recombinant Mouse S1PR5 Protein Mammalian Cell His
Mouse S1PR5-7875M-B Recombinant Mouse S1PR5 Protein Pre-coupled Magnetic Beads HEK293
Mouse S1PR5-7875M Recombinant Mouse S1PR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat S1PR5-5221R Recombinant Rat S1PR5 Protein Mammalian Cell His
Rat S1PR5-4880R Recombinant Rat S1PR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat S1PR5-4880R-B Recombinant Rat S1PR5 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL21351HF Recombinant Full Length Human Sphingosine 1-Phosphate Receptor 5(S1Pr5) Protein, His-Tagged E.coli expression system His Full Length (1-398)
Mus musculus (Mouse) RFL14691MF Recombinant Full Length Mouse Sphingosine 1-Phosphate Receptor 5(S1Pr5) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Rattus norvegicus (Rat) RFL7317RF Recombinant Full Length Rat Sphingosine 1-Phosphate Receptor 5(S1Pr5) Protein, His-Tagged E.coli expression system His Full Length (1-400)
Sus scrofa (Pig) RFL5927SF Recombinant Full Length Pig Sphingosine 1-Phosphate Receptor 5(S1Pr5) Protein, His-Tagged E.coli expression system His Full Length (1-398)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

S1PR5 involved in several pathways and played different roles in them. We selected most pathways S1PR5 participated on our site, such as Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with S1PR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwayBID;FYN;KRAS;SGMS1;BCL2;RAF1;SMPD1;PIK3R1;RHOA
Neuroactive ligand-receptor interactionCHRND;P2RY1;GRM6;GRIK4;GRIN3A;GHSRA;OPRL1;TAAR14E;C5AR1

S1PR5 has several biochemical functions, for example, sphingosine-1-phosphate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by S1PR5 itself. We selected most functions S1PR5 had, and list some proteins which have the same functions with S1PR5. You can find most of the proteins on our site.

Function Related Protein
sphingosine-1-phosphate receptor activitySPHK1;S1PR5B;GPR6;S1PR3A;S1PR5A;S1PR2;S1PR3;S1PR1;S1PR4

S1PR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S1PR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of S1PR5.

TP63

Research Area

Related articles

Wang, CY; Mao, JH; et al. Systemic distribution, Subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues. EXPERIMENTAL AND MOLECULAR PATHOLOGY 97:259-265(2014).
Takabe, K; Spiegel, S; et al. Export of sphingosine-1-phosphate and cancer progression. JOURNAL OF LIPID RESEARCH 55:1839-1846(2014).
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