SDC2

  • Official Full Name

    syndecan 2

  • Overview

    The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
  • Synonyms

    SDC2; syndecan 2; HSPG; CD362; HSPG1; SYND2; syndecan-2; fibroglycan; syndecan proteoglycan 2; heparan sulfate proteoglycan core protein; cell surface-associated heparan sulfate proteoglycan 1; heparan sulfate proteoglycan 1, cell surface-associated;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SDC2-501H Active Recombinant Human Syndecan 2, His-tagged Mammalian cells His
Human SDC2-334H Active Recombinant Human SDC2, His-tagged Mammalian cells His
Human SDC2-213H Recombinant Human SDC2 Protein, His-tagged HEK293 His
Human SDC2-2835H Recombinant Human SDC2 protein, His-tagged E.coli His Glu19~Glu144
Human SDC2-1575HCL Recombinant Human SDC2 cell lysate N/A
Human SDC2-127H Recombinant Human SDC2 Protein, C-His-tagged E.coli C-His
Human SDC2-5081H Recombinant Human SDC2 Protein (Met1-Glu144), C-His tagged Mammalian cells C-His Met1-Glu144
Human SDC2-4033H Recombinant Human SDC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SDC2-6249H Recombinant Human SDC2 Protein (Glu19-Glu144), C-His tagged Mammalian cells C-His Glu19-Glu144
Human SDC2-4033H-B Recombinant Human SDC2 Protein Pre-coupled Magnetic Beads HEK293
Human SDC2-2836H Recombinant Human SDC2 protein, His-tagged E.coli His 20-147 aa
Human SDC2-1445H Recombinant Human SDC2 Protein (Glu19-Glu144), His tagged E.coli His Glu19-Glu144
Human SDC2-66H Recombinant Human SDC2 Protein, His-tagged Human Cell His
Human SDC2-2728H Recombinant Human SDC2 protein(61-140 aa), C-His-tagged E.coli C-His 61-140 aa
Mouse SDC2-14790M Active Recombinant Mouse SDC2 Protein HEK293 N/A
Mouse SDC2-846M Recombinant Mouse SDC2 Protein (Met1-Phe141), His-tagged HEK293 His Met1-Phe141
Mouse Sdc2-2766M Recombinant Mouse Sdc2 Protein, His-tagged E.coli N-His Glu19-Glu145
Rat SDC2-5285R Recombinant Rat SDC2 Protein Mammalian Cell His
Rat SDC2-4944R Recombinant Rat SDC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SDC2-4944R-B Recombinant Rat SDC2 Protein Pre-coupled Magnetic Beads HEK293
Rat SDC2-529R Recombinant Rat SDC2 Protein, Fc-tagged HEK293 Fc Met1-Pro694
Homo sapiens (Human) RFL23033HF Recombinant Full Length Human Syndecan-2(Sdc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-201)
Mus musculus (Mouse) RFL7409MF Recombinant Full Length Mouse Syndecan-2(Sdc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-202)
Rattus norvegicus (Rat) RFL16761RF Recombinant Full Length Rat Syndecan-2(Sdc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-201)
Rhesus Macaque SDC2-4106R Recombinant Rhesus monkey SDC2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SDC2-3923R Recombinant Rhesus Macaque SDC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SDC2-3923R-B Recombinant Rhesus Macaque SDC2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SDC2-9497Z Recombinant Zebrafish SDC2 Mammalian Cell His
Chicken SDC2-1105C Recombinant Chicken SDC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SDC2 involved in several pathways and played different roles in them. We selected most pathways SDC2 participated on our site, such as Cell adhesion molecules (CAMs), Malaria, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD58;CD8B1;ITGB2L;CNTNAP2A;CLDN11;SELP;NRXN1A;CLDN5B;CDH5
MalariaIL1B;LRP1;DARC;HBA-A2;TNF;VCAM1;TLR2;IL6;IL12A
Proteoglycans in cancerPLCG2;ARHGEF12;ITGB5;PLCE1;GPC1;ROCK2;TRP53;TWIST2;PIK3R3

SDC2 has several biochemical functions, for example, PDZ domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC2 itself. We selected most functions SDC2 had, and list some proteins which have the same functions with SDC2. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingATP2B3A;SRR;KIDINS220B;PTENA;USHBP1;GRM7;ARHGAP29;EXOC4;DLG4
protein bindingNOX1;HNRNPH3;TNFSF13B;TMEM110;SERPINF2;C14orf159;DTX2;NLRX1;FGF7

SDC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC2.

CASK; SDCBP; MYB; RASA1; GAMMAHV.ORF30; SERPINA1; NF1; CYP2C18; BAG6; PPP3CC; mtlA; CSNK2A2; PYHIN1

Research Area

Related articles

Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
Zhang, YH; Wang, NN; et al. Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity. JOURNAL OF BIOLOGICAL CHEMISTRY 288:12090-12101(2013).
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