serpina1

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serpina1

Official Full Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Background The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Synonyms SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275; MGC23330; serine proteinase inhibitor, clade A, member 1; OTTHUMP00000197150; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin serine (or cysteine) proteinase inhibitor, clade A, member 1
    • Species :
    • Chicken
    • Dog
    • Horse
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Human Cell
    • Human Plasma
    • Mammalian Cell
    • Oryza Sativa
    • Rice Grain
    • Yeast
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat SERPINA1-1514R Recombinant Rat SERPINA1 Protein (25-411 aa), His-tagged Yeast His
    Human SERPINA1-011O Recombinant Human SERPINA1 Oryza Sativa N/A
    Human SERPINA1-050H Recombinant Human SERPINA1 Protein, His-tagged E.coli His
    Human SERPINA1-20H Alpha-1-Antitrypsin(plasma derived) Reference standard N/A
    Human SERPINA1-258H Recombinant Human SERPINA1 protein Rice Grain N/A
    Human SERPINA1-27286TH Native Human SERPINA1 N/A
    Human SERPINA1-2856HCL Recombinant Human SERPINA1 cell lysate Human Cell N/A
    Human SERPINA1-4H Human Alpha 1-Antitrypsin Reference Standard N/A
    Human SERPINA1-518H Recombinant Human SERPINA1 E.coli N/A
    Human SERPINA1-5358H Native Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 1 Human Plasma N/A
    Human SERPINA1-8009H Native Human Serum Alpha 1 AntiTrypsin Human Plasma N/A
    Human SERPINA1-854H Recombinant Human SERPINA1 protein, His-tagged HEK293 His
    Human SERPINA1-866H Recombinant Human SERPINA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SERPINA1-P035H Native Human alpha-1 proteinase inhibitor therapeutic protein (Aralast, Aralast NP, Glassia, Prolastin, Prolastin-C, Zemaira) human plasma N/A
    Mouse SERPINA1-32M Mouse Alpha 1-Antitrypsin Reference Standard N/A
    Mouse Serpina1a-3309M Recombinant Mouse Serpina1a, His-tagged E.Coli or Yeast His
    Rat a1AT-3308R Recombinant Rat a1AT, His-tagged E.coli His
    Rat SERPINA1-1119R Recombinant Rat SERPINA1 Protein, His-tagged HEK293 His
    Rat SERPINA1-5334R Recombinant Rat SERPINA1 Protein Mammalian Cell His
    Rhesus Macaque SERPINA1-4147R Recombinant Rhesus monkey SERPINA1 Protein, His-tagged Mammalian Cell His
    Dog SERPINA1-17D Dog Alpha 1-Antitrypsin Reference Standard N/A
    Chicken SERPINA1-4886C Recombinant Chicken SERPINA1 Mammalian Cell His
    Zebrafish SERPINA1-4841Z Recombinant Zebrafish SERPINA1 Mammalian Cell His
    Horse SERPINA1-256H Recombinant Horse SERPINA1 protein, His-tagged Mammalian Cell His

    serpina1 involved in several pathways and played different roles in them. We selected most pathways serpina1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with serpina1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades C5; KNG1; F9; A2M; SERPINA1E; C1S; MBL2; CR2; SERPINE1; THBD

    serpina1 has several biochemical functions, for example, glycoprotein binding, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by serpina1 itself. We selected most functions serpina1 had, and list some proteins which have the same functions with serpina1. You can find most of the proteins on our site.

    Function Related Protein
    glycoprotein binding ITGB2; OS9; LDLR; DNAJC5; SERPINA1A; HFE2; CD4; LACRT; SHB; FGFR1
    identical protein binding TPCN1; MAP1S; LYZ; TNN; FHL2; DYNLT1A; C1QL2; DYNLT1; GOT2B; LRRK1
    protease binding DPP4; Serpina1c; PINK1; HSPD1; MBL1; PYCARD; INS; TNF; TIMP2; RNF139
    protein binding ARMCX5; P4HA2; ZNF581; RERE; GTPBP10; CACNB4; IRAK2; ITGB2; MYBPH; ZBTB2
    serine-type endopeptidase inhibitor activity SERPINA3; WFDC5; SERPINA1; A2M; SERPINF1; SPINT2; SERPINB1L4; SERPINB4; SERPINB11; SPINK1

    serpina1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with serpina1 here. Most of them are supplied by our site. Hope this information will be useful for your research of serpina1.

    try1_bovin; CELA1; SSR1; ELANE; tryp_sacer; CANX; espB

    Watts, RA; MacGregor, AJ; et al. HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. RHEUMATOLOGY 54:359-362(2015).
    Perez-Rubio, G; Jimenez-Valverde, LO; et al. Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values. ARCHIVOS DE BRONCONEUMOLOGIA 51:80-85(2015).

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