SETD2

  • Official Full Name

    SET domain containing 2

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
  • Synonyms

    SETD2; SET domain containing 2; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; histone-lysine N-methyltransferase SETD2; huntingtin yeast partner B; lysine N-methyltransferase 3A; huntingtin interacting protein 1; huntingtin-interacting protein B;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SETD2-69H Active Recombinant Human SETD2, FLAG-tagged Sf9 Insect Cell Flag
Human SETD2-199H Active Recombinant Human SETD2 protein, GST-tagged Insect Cell GST
Human SETD2-460H Recombinant Human SET Domain Containing 2, GST-tagged E.coli GST
Human SETD2-188H Recombinant Human SETD2 Protein, GST-tagged E.coli GST
Human SETD2-189H Recombinant Human SETD2 Protein, His-tagged E.coli His
Human SETD2-461H Recombinant Human SETD2, GST-tagged E.coli GST
Human SETD2-260H Recombinant Human SETD2 protein, GST-tagged E.coli GST
Human SETD2-259H Recombinant Human SETD2 protein E.coli N/A
Human SETD2-27850TH Recombinant Human SETD2 E.coli N/A
Human SETD2-023H Recombinant Human SETD2 Protein, His-tagged E.coli His
Human SETD2-116H Recombinant Human SETD2 Protein, His-tagged E. coli His
Mouse SETD2-14979M Recombinant Mouse SETD2 Protein Mammalian Cell His
Mouse SETD2-8067M-B Recombinant Mouse SETD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SETD2-8067M Recombinant Mouse SETD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-1864 SETD2 Chemiluminescent Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SETD2 Related Articles
  • SETD2 Related Research Area

SETD2 involved in several pathways and played different roles in them. We selected most pathways SETD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationALDH7A1;ACAT2;SUV39H2;PIPOX;PLOD1;ALDH9A1A.1;HADHA;PLOD3;SUV420H2

SETD2 has several biochemical functions, for example, histone methyltransferase activity (H3-K36 specific), histone-lysine N-methyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD2 itself. We selected most functions SETD2 had, and list some proteins which have the same functions with SETD2. You can find most of the proteins on our site.

Function Related Protein
histone methyltransferase activity (H3-K36 specific)SETD2;SMYD2;SMYD2B;NSD1;ASH1L;SMYD2A;SETMAR;SETD3
histone-lysine N-methyltransferase activitySETD1B;EHMT1B;SETD8;SUV39H1;SETD2;SETD7;PRDM9;EZH2;SETDB1B
protein bindingPOLG;VAT1L;CD37;FAM113B;MED8;STK11;ZSCAN21;RPL7A;LPAL2

SETD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD2.

SMAD3; SIAH2; HTT; ATXN1; fdoH; argS; CIC; q9wmx2-pro_0000037541; q9wmx2-pro_0000037544; q9wmx2-pro_0000037545; q9wmx2-pro_0000037547; q9wmx2-pro_0000037552; Soga1; Ttll7; CLK2; RASSF8

Newbold, RF; Mokbel, K; et al. Evidence for a Tumour Suppressor Function of SETD2 in Human Breast Cancer: A New Hypothesis. ANTICANCER RESEARCH 30:3309-3311(2010).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SETD2 Products

Required fields are marked with *

My Review for All SETD2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends