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Recombinant Human SETD2 Protein, His-tagged

Cat.No. : SETD2-023H
Product Overview : Recombinant Human SETD2 protein (1435-1711) with a N-terminal His-tag was expressed in E. coli.
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Description : Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 33.7 kDa
Protein length : 1435-1711
Purity : ≥95% estimated by SDS-PAGE
Stability : ≥ 9 months
Storage : -80 centigrade
Storage Buffer : 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Gene Name : SETD2 SET domain containing 2, histone lysine methyltransferase [ Homo sapiens (human) ]
Official Symbol : SETD2
Synonyms : SETD2; SET domain containing 2, histone lysine methyltransferase; LLS; HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP; histone-lysine N-methyltransferase SETD2; SET domain containing 2; huntingtin interacting protein 1; huntingtin yeast partner B; huntingtin-interacting protein B; lysine N-methyltransferase 3A; protein-lysine N-methyltransferase SETD2; EC 2.1.1.359
Gene ID : 29072
mRNA Refseq : NM_014159
Protein Refseq : NP_054878
MIM : 612778
UniProt ID : Q9BYW2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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