Recombinant Full Length Human SLC2A4 Protein, C-Flag-tagged

• Cat.No.: SLC2A4-805HFL
• Product Overview: Recombinant Full Length Human SLC2A4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.6 kDa
• AA Sequence: MPSGFQQIGSEDGEPPQQRVTGTLV LAVFSAVLGSLQFGYNIGVINAPQK VIEQSYNETWLGRQGPEGPS SIPPGTLTTLWALSVAIFSVGGMIS SFLIGIISQWLGRKRAMLVNNVLAV LGGSLMGLANAAASYEMLIL GRFLIGAYSGLTSGLVPMYVGEIAP THLRGALGTLNQLAIVIGILIAQVL GLESLLGTASLWPLLLGLTV LPALLQLVLLPFCPESPRYLYIIQN LEGPARKSLKRLTGWADVSGVLAEL KDEKRKLERERPLSLLQLLG SRTHRQPLIIAVVLQLSQQLSGINA VFYYSTSIFETAGVGQPAYATIGAG VVNTVFTLVSVLLVERAGRR TLHLLGLAGMCGCAILMTVALLLLE RVPAMSYVSIVAIFGFVAFFEIGPG PIPWFIVAELFSQGPRPAAM AVAGFSNWTSNFIIGMGFQYVAEAM GPYVFLLFAVLLLGFFIFTFLRVPE TRGRTFDQISAAFHRTPSLL
  EQEVKPSTELEYLGPDENDTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Insulin signaling pathway, Type II diabetes mellitus

Gene Information

• Gene Name: SLC2A4 solute carrier family 2 member 4 [ Homo sapiens (human) ]
• Official Symbol: SLC2A4
• Synonyms: GLUT4
• Gene ID: 6517
• mRNA Refseq: NM_001042.3
• Protein Refseq: NP_001033.1
• MIM: 138190
• UniProt ID: P14672