slit2
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  • Official Full Name
  • slit homolog 2 (Drosophila)
  • Background
  • Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
  • Synonyms
  • SLIT2; slit homolog 2 (Drosophila); SLIL3, slit (Drosophila) homolog 2; slit homolog 2 protein; Slit 2; SLIL3; Slit-2; FLJ14420
Cat.#:Slit2-18MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Slit2 Protein, His-tagged
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Cat.#:SLIT2-30441THTag:
Source (Host):Species:Human
Product nameRecombinant Human SLIT2
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Cat.#:SLIT2-402HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SLIT2 Protein
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Cat.#:SLIT2-757HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLIT2 protein, His-tagged
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Cat.#:SLIT2-758HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SLIT2 protein, His-tagged
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Cat.#:SLIT2-965HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Slit Homolog 2 (Drosophila)
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Cat.#:SLIT2-15563MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLIT2 Protein
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Cat.#:Slit2-20MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Slit2, His-tagged
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Cat.#:Slit2-759MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Slit2 protein, His-tagged
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Cat.#:Slit2-760MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Slit2 protein, His-tagged
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Cat.#:Slit2-761RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Slit2 protein, His-tagged
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Cat.#:SLIT2-4636CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLIT2
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Cat.#:SLIT2-9255ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLIT2
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Cat.#:SLIT2-1683HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SLIT2 293 Cell Lysate
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Involved Pathway

SLIT2 involved in several pathways and played different roles in them. We selected most pathways SLIT2 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLIT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
SPNA1; LAMTOR2; ITGB1; MYL12A; DPYSL4; KIF4A; PPP3CB; DCX; EPHA2A; MARK3

Protein Function

SLIT2 has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLIT2 itself. We selected most functions SLIT2 had, and list some proteins which have the same functions with SLIT2. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase inhibitor activity
Related Protein TNK2; RHOH; ARL2; GPS2; CDC42SE1; PDE6D; SLIT2; RTKN; CPEB2; UBE4A
Function Roundabout binding
Related Protein SLIT3; UBE4A; GM4980; TGFB1I1; SLIT1; SLIT1A; SLIT1B; SLIT2
Function calcium ion binding
Related Protein THBS3A; CALM2; PCDH8; MMP20; RCV1; PCDH2AB7; HPCA; CDH10; EFCAB12; MYL12B
Function chemorepellent activity
Related Protein APOA1; SEMA3FA; SEMA3E; NRG1; SEMA3GA; SEMA6DL; FLRT2; SEMA4C; SEMA3AB; SEMA3H
Function heparan sulfate proteoglycan binding
Related Protein HPSE2; SLIT2; GPC6A; GPC4; GPC1A; PLA2G2D; GPC1B; ITGAM; Gpc2; Itgam&Itgb2
Function heparin binding
Related Protein CXCL13; GPNMB; PTPRFB; ITGAM; AZU1; RSPO4; OGN; HDGF; VEGFA; GREM2
Function identical protein binding
Related Protein NOL3; SNX8; ACTB; MNS1; EPOR; PRMT8; GLUD1; RILPL2; CNTN2; GOT1L1
Function laminin-1 binding
Related Protein Shh; DAG1; NID1; NTN4; LACRT; UBE4A; SLIT2
Function protein binding
Related Protein CRYGC; TJP2; CDKN2C; CRY1; FAM50B; TNIK; SOX-2; KLHL3; CETN1; DRG1
Function protein homodimerization activity
Related Protein VAPB; TKT; DMRTC1B; NR2C1; IL6R; ADH5; HNF1B; VPS25; S100A13; TESC
Function proteoglycan binding
Related Protein CECR1A; SLIT2; CTSB; CTSS; FCN2; CECR1; NID1; COL5A1; CTSL1; CTSK

Interacting Protein

SLIT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLIT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLIT2.
ETS1; BILF1; mgtA; yfiS; q8clc4_yerpe; q9wmx2-pro_0000037546; q9wmx2-pro_0000037548; MYC

SLIT2 Related Articles

Qi, CL; Lan, HM; et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. LABORATORY INVESTIGATION 94:766-776(2014).
Pircher, A; Wellbrock, J; et al. New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules. ONCOLOGY 86:46-52(2014).