SNX1
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Official Full Name
sorting nexin 1 -
Overview
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. -
Synonyms
SNX1;sorting nexin 1;sorting nexin-1;HsT17379;MGC8664;SNX1A;Vps5;sorting nexin 1A
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Non
- DDK
- Myc
- Avi
- Fc
- SUMO
Involved Pathway
SNX1 involved in several pathways and played different roles in them. We selected most pathways SNX1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | FAM21A,SNX3,KDRL,RAB10,HSPA2,LDLR,PARD6GB,CYTH1B,ARPC5LA,CYTH4 |
Protein Function
SNX1 has several biochemical functions, for example, epidermal growth factor receptor binding,identical protein binding,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNX1 itself. We selected most functions SNX1 had, and list some proteins which have the same functions with SNX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TOP2B,HIST2H3C,THRA,CYBA,HSPD1,CRLF1,HIST1H3H,TENM3,NFYC,ABCG8 |
| transferrin receptor binding | CD81,HFE2,RGMA,TF,SNX4,Trf,SNX2,HFE |
| epidermal growth factor receptor binding | FAM83B,SNX4,Fert2,GRB2,BTC,SOCS5,LINGO1,VAV2,MS4A1,SHC1 |
| protein binding | CCND3,SCAND1,PAN3,TJAP1,GDF2,TGFB1I1,SETDB2,CCNB1,MSI2,SUB1 |
| leptin receptor binding | SNX2,SNX4 |
| phosphatidylinositol binding | TULP4A,ARHGAP32,HIP1,RPS6KC1,SNX22,SNX1B,SNX31,ITPR1,PIK3C2A,ZCCHC2 |
| protein homodimerization activity | BMP4,MYH9,VIL1,DAXX,MTERFD3,ENO2,PDGFA,ERN1,HIF1AN,TSC2 |
| identical protein binding | DCP1A,CD28,RIPK1,THG1L,PIK3AP1,LECT2,KCTD13,SMURF2,HSP90AA1,ANXA4 |
| insulin receptor binding | DOK2,ENPP1,INS1,PHIP,DOK5,FRS2A,INS2,DOK3,SNX4,SHC1 |
Interacting Protein
SNX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNX1.
ARL6IP1;SNX32;REEP6;pi3p;RTN3
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