Recombinant Human Sorting Nexin 1, His-tagged

• Cat.No.: SNX1-2800H
• Product Overview: Recombinant human SNX1 protein (146-522aa), fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 146-522 a.a.
• Description: SNX1 (Sorting nexin 1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor.
• Sequences: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGGSMTV GITDPEKIGD GMNAYVAYKV TTQTSLPLFR SKQFAVKRRF SDFLGLYEKL SEKHSQNGFI VPPPPEKSLI GMTKVKVGKE DSSSAEFLEK RRAALERYLQ RIVNHPTMLQ DPDVREFLEK EELPRAVGTQ TLSGAGLLKM FNKATDAVSK MTIKMNESDI WFEEKLQEVE CEEQRLRKLH AVVETLVNHR KELALNTAQF AKSLAMLGSS EDNTALSRAL SQLAEVEEKI EQLHQEQANN DFFLLAELLS DYIRLLAIVR AAFDQRMKTW QRWQDAQATL QKKREAEARL LWANKPDKLQ QAKDEILEWE SRVTQYERDF ERISTVVRKE VIRFEKEKSK DFKNHVIKYL ETLLYSQQQL AKYWEAFLPE AKAIS.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M Nacl, 1mM DTT, 10% glycerol.
• Molecular Weight: 48.0 kDa (415aa),confirmed by MALDI-TOF.
• Purity: > 90% by SDS – PAGE.
• Concentration: 0.25 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SNX1 sorting nexin 1 [ Homo sapiens ]
• Synonyms:
  SNX1;sorting nexin 1; sorting nexin 1A; sorting nexin-1; Vps5; SNX1A; MGC8664; HsT17379
• Gene ID: 6642
• mRNA Refseq: NM_003099
• Protein Refseq: NP_003090
• MIM: 601272
• UniProt ID: Q13596
• Chromosome Location: 15q22.31
• Function: phosphoinositide binding; protein binding; protein transporter activity