SPI1

  • Official Full Name

    spleen focus forming virus (SFFV) proviral integration oncogene spi1

  • Overview

    This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell;development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of;target genes, and regulates their expression in coordination with other transcription factors and cofactors. The;protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different;isoforms have been found for this gene.
  • Synonyms

    SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1; 31 kDa transforming protein; hematopoietic transcription factor PU.1; OF; PU.1; SFPI1; SPI 1; SPI 1 proto oncogene; SPI A; SPI-1 proto-oncogene; 31 kDa-transforming protein; SPI-1; SPI-A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPI1-172H Recombinant Human SPI1 protein, His-tagged E.coli His
Human SPI1-173H Recombinant Human SPI1 protein, His-tagged E.coli His
Human SPI1-1683HCL Recombinant Human SPI1 cell lysate N/A
Rat SPI1-5706R Recombinant Rat SPI1 Protein Mammalian Cell His
Rat SPI1-5365R Recombinant Rat SPI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPI1-5365R-B Recombinant Rat SPI1 Protein Pre-coupled Magnetic Beads HEK293
Chicken SPI1-6580C Recombinant Chicken SPI1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPI1 Related Research Area

SPI1 involved in several pathways and played different roles in them. We selected most pathways SPI1 participated on our site, such as Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationPPP3CA;TREM2;MAPK3;TNFRSF11B;IL1B;IFNGR2;PIK3R2;MITF;PIK3R3
HTLV-I infectionHLA-DRB1;POLE4;NFATC4;FOS;ANAPC11;ETS2;IL1R2;TLN1;SPI1
Epstein-Barr virus infectionSKP2;Fcer2a;DDX58;PSMC6;CD58;POLR2K;FGR;YWHAB;POLR2J2
Pathways in cancerSMAD3;PTGER3;GSK3B;IL-8;LAMA5;FGF6;DAPK3;PDGFRA;BIRC3
Transcriptional misregulation in cancerELANE;HIST2H3C1;ID2;HIST1H3F;HIST3H3;BMI1;SMAD1;MYCN;RUNX1
Acute myeloid leukemiaSTAT3;CHUK;MAP2K2;SPI1;KIT;EIF4EBP1;MAP2K1;FLT3;RELA

SPI1 has several biochemical functions, for example, NFAT protein binding, RNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPI1 itself. We selected most functions SPI1 had, and list some proteins which have the same functions with SPI1. You can find most of the proteins on our site.

Function Related Protein
NFAT protein bindingMAPK14;SFPI1;GATA4;PPARA;FOXP3;SPI1
RNA bindingEIF1AXB;LIN28B;HNRNPU;TRNAU1APA;HNRNPH2;RALY;GRB7;ILF3;YY1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingSOX1;CLOCK;NEUROD1;ZNF664;CEBPZ;IFI203;GMEB1;HOXA5;RFX3
RNA polymerase II core promoter sequence-specific DNA bindingPAX8;SP3;MITF;GATA6;SOX3;HNF4A;TAL1;RBPJ;TBR1
RNA polymerase II distal enhancer sequence-specific DNA bindingPROP1;HNRNPC;NR5A1;ZBTB16;T;HOXB5;MIXL1;BACH1;TFAP2C
RNA polymerase II transcription factor activity, sequence-specific DNA bindingETV3;PLAGL2;FOXN2B;FOXP1;SOX14;FOXA1;FOXQ1B;HIF1AB;MITFA
RNA polymerase II transcription factor bindingSMAD4;SFPI1;Ar;NFATC1;MTDH;TBX6;TBX3;TBX20;T
core promoter bindingAGO2;IFI16;KLF4;MYOG;SPI1;HDAC4;NEUROG3;NPAS2;SFPI1
protein bindingTTC8;GRIN1;SSX2;ZNHIT6;PRMT2;CLCF1;AMY1B;ADIPOQ;UBR1
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingFOXC2;FOXF2A;OLIG2;AHR;NKX2;GTF2IRD1;CREB1;PKNOX1;MYF6
transcription factor activity, sequence-specific DNA bindingTEAD1;ETV5;CNOT8;ATF5A;FOXG1;FOXF2;MAFGA;HEY1;RORCA
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSOX2;BATF;TFAP2E;TCF12;PPARA;CEBPA;GLI2;ALS2CR8;TFAP2A
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingZEB2;MEOX2;SFPI1;MIXL1;HCFC1;SIX3;REL;BACH1;NFKB1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingREST;AEBP2;BCL11AA;DACH1;NFATC4;PRDM1;BACH1;NR2C1;OVOL1

SPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPI1.

PML-RAR

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SPI1 Products

Required fields are marked with *

My Review for All SPI1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends