SPI1
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Official Full Name
spleen focus forming virus (SFFV) proviral integration oncogene spi1
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Overview
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell;development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of;target genes, and regulates their expression in coordination with other transcription factors and cofactors. The;protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different;isoforms have been found for this gene. -
Synonyms
SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1; 31 kDa transforming protein; hematopoietic transcription factor PU.1; OF; PU.1; SFPI1; SPI 1; SPI 1 proto oncogene; SPI A; SPI-1 proto-oncogene; 31 kDa-transforming protein; SPI-1; SPI-A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- His
- Fc
- Avi
- N
- C
- Myc
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SPI1-172H |
Recombinant Human SPI1 protein, His-tagged
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E.coli | His | ||
| Human | SPI1-173H | Recombinant Human SPI1 protein, His-tagged | E.coli | His |
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| Human | SPI1-1683HCL | Recombinant Human SPI1 cell lysate | Non |
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| Mouse | Spi1-4533M | Recombinant Mouse Spi1 protein, His&Myc-tagged | E.coli | N-His&C-Myc | 1-272aa |
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| Rat | SPI1-5706R | Recombinant Rat SPI1 Protein | Mammalian Cell | His |
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| Rat | SPI1-5365R | Recombinant Rat SPI1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | SPI1-5365R-B | Recombinant Rat SPI1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | SPI1-6580C | Recombinant Chicken SPI1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SPI1 involved in several pathways and played different roles in them. We selected most pathways SPI1 participated on our site, such as Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | LILRA3;PIK3CA;LILRA4;GAB2;IFNG;MITF;FOS;ITGB3;LILRB1 |
| HTLV-I infection | ATF1;ANAPC4;MYBL2;HLA-DRB5;HLA-B;WNT5B;TGFBR1;PIK3CD;HLA-DRB1 |
| Epstein-Barr virus infection | PIK3CA;ITGAL;SPI1;PSMC6;TYK2;POLR3H;HLA-DRB5;HSPA1A;MAPK9 |
| Pathways in cancer | AGTR1A;WNT3A;GNAS;Pdgfa&Pdgfb;RUNX1T1;WNT10B;PTGER4;GNGT1;BMP2 |
| Transcriptional misregulation in cancer | TGFBR2;PTK2;PML;HMGA2;RXRG;FLT1;CD40;MLLT3;REL |
| Acute myeloid leukemia | MYC;PML;STAT5B;STAT3;MAPK1;PPARD;PIK3CB;RARA;JUP |
SPI1 has several biochemical functions, for example, NFAT protein binding, RNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPI1 itself. We selected most functions SPI1 had, and list some proteins which have the same functions with SPI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NFAT protein binding | SFPI1;SPI1;FOXP3;PPARA;MAPK14;GATA4 |
| RNA binding | METTL3;RNASEH2A;NCL;DUSP11;FMR1;EWSR1;LIN28B;ADARB1A;TRIM71 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | Ar;CC2D1B;NR5A2;FEZF2;NPAS4;MYPOP;PRDM1;HNRNPK;HOXA2 |
| RNA polymerase II core promoter sequence-specific DNA binding | TFAP2B;HNF4A;MAZ;RBPJ;PAX6;SOX8;SP1;TBR1;SFPI1 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | BACH1A;SFPQ;CREB1;TAL1;H3F3A;NFE2L2;NFATC1;NR2F6;H2AFZ |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | ATF5A;TFE3A;FOXB1A;PAX6B;FOXK1;ZNF496;ETV2;SPI1A;LYL1 |
| RNA polymerase II transcription factor binding | GATA6;ANKRD1;MIXL1;GSK3B;ZFPM2;SMAD4;GATA5;ZGLP1;PITX2 |
| core promoter binding | SPI1;EP300;EZH2;TFAP2C;RB1;PYDC3;MYBBP1A;CLOCK;E2F2 |
| protein binding | Abcb1b;KIF7;DNAJB4;FANCB;IRF5;RTN4A;YAP1;CACNA2D1A;KRT1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | NR5A2;SRY;SOX7;MEF2A;RFX1;LEF1;NKX2-1;FOXF2A;SNAI2 |
| transcription factor activity, sequence-specific DNA binding | TBX1;ZFP131;PRDM15;BTBD8;SOX11B;HSF5;ZFP191;CTCF;ALX3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ESRRA;ETV2;FOXK2;MZF1;JUNB;PLSCR1;MEF2C;SIX2;TRP63 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | SFPI1;ZEB2;PROP1;SIX3;NFATC1;CDX1;NFE2L1;REL;NFE2L2 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | MZF1;ZFPM2A;TGIF1;GFI1;HAND1;RCOR1;PROX2;SP3;IFI203 |
SPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPI1.
PML-RAR
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