SPI1

  • Official Full Name

    spleen focus forming virus (SFFV) proviral integration oncogene spi1

  • Overview

    This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell;development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of;target genes, and regulates their expression in coordination with other transcription factors and cofactors. The;protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different;isoforms have been found for this gene.
  • Synonyms

    SPI1; spleen focus forming virus (SFFV) proviral integration oncogene spi1; transcription factor PU.1; 31 kDa transforming protein; hematopoietic transcription factor PU.1; OF; PU.1; SFPI1; SPI 1; SPI 1 proto oncogene; SPI A; SPI-1 proto-oncogene; 31 kDa-transforming protein; SPI-1; SPI-A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPI1-172H Recombinant Human SPI1 protein, His-tagged E.coli His
Human SPI1-173H Recombinant Human SPI1 protein, His-tagged E.coli His
Human SPI1-1683HCL Recombinant Human SPI1 cell lysate N/A
Rat SPI1-5706R Recombinant Rat SPI1 Protein Mammalian Cell His
Rat SPI1-5365R Recombinant Rat SPI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPI1-5365R-B Recombinant Rat SPI1 Protein Pre-coupled Magnetic Beads HEK293
Chicken SPI1-6580C Recombinant Chicken SPI1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SPI1 involved in several pathways and played different roles in them. We selected most pathways SPI1 participated on our site, such as Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Osteoclast differentiationIFNAR1;NOX1;MITF;MAPK9;MAPK10;IL1A;IL1R1;GAB2;PIK3CA
HTLV-I infectionNRP1;CRTC1;RB1;TNF;VDAC3;SPI1;SLC25A5;IKBKG;IL2RA
Epstein-Barr virus infectionHLA-A;ENTPD8;IRAK1;POLR1D;POLR3F;IKBKB;PLCG2;IL10RA;MAPK9
Pathways in cancerFGF16;PGF;FGFR1;WNT9B;RALGDS;WNT8A;FGF21;MTOR;PLCB3
Transcriptional misregulation in cancerHIST1H3D;HIST1H3C;TRAF1;SUPT3H;PML;DEFA3;IL6;FUT8;PBX1
Acute myeloid leukemiaRPS6KB2;TCF7L2;PIK3CG;RARA;SPI1;BRAF;TCF7;STAT5A;PPARD

SPI1 has several biochemical functions, for example, NFAT protein binding, RNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPI1 itself. We selected most functions SPI1 had, and list some proteins which have the same functions with SPI1. You can find most of the proteins on our site.

Function Related Protein
NFAT protein bindingGATA4;PPARA;SPI1;SFPI1;FOXP3;MAPK14
RNA bindingSF3B3;QKIA;SRP14;SF1;PUS3;EIF4EA;CRNKL1;ZMAT4;UPF1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNFIB;PRDM5;EHF;MITFB;PDX1;TFAP2E;ESRRA;FOS;SPI1
RNA polymerase II core promoter sequence-specific DNA bindingFOS;SFPI1;HOXB3;H2AFY;NSD1;RREB1;NR4A2;WBP2;STAT6
RNA polymerase II distal enhancer sequence-specific DNA bindingFLI1;POU4F1;PROP1;H3F3A;NFKB1;RXRB;ESRRB;SOX10;MSC
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXB1A;PLAGL2;ERF;FOXD5;ZMYM5;FOXC1B;FOXD2;ELF2;RUNX2B
RNA polymerase II transcription factor bindingTBX20;T;WWP2;ZFPM2A;ATF4;Ar;GATA1A;TBX6;NFATC1
core promoter bindingDHX36;CALCOCO1;E2F2;XBP1;NKX3;INSM1B;RELB;PYDC3;MYOD1
protein bindingINPP5K;ABI3;PPP1R2P9;MSRB3;MED4;MCM10;BLK;ATXN1L;CD40
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingPOU3F3;MYOD1;NR5A1;OLIG2;USF1;PTH;TEAD2;USF2;SRY
transcription factor activity, sequence-specific DNA bindingFOXF2;HINFP;NR1H5;ZFP354B;RAI1;TRP53;TBX18;EOMESA;TBX1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMITFA;ZFP750;MITFB;ESRRA;AKNA;CTCFL;CREB3;OTX1;TFE3A
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingSIX6;SPI1;TARDBP;CDX1;FUBP1;FOXH1;MEOX2;CUX1;MIXL1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingBATF3;HHEX;BACH1;NKX6-1;TGIF1;GATA1;BTG2;KCNIP3;ETS2

SPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPI1.

PML-RAR

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SPI1 Products

Required fields are marked with *

My Review for All SPI1 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /
  • Service lnquiry:

Stay Updated on the Latest Bioscience Trends