STAT5B

  • Official Full Name

    Signal Transducer And Activator Of Transcription 5B

  • Overview

    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).
  • Synonyms

    STAT5B; signal transducer and activator of transcription 5B; STAT5; OTTHUMP00000198374; transcription factor STAT5B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Human, Mouse, Rat
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT5B-74H Recombinant Human STAT5B, GST-tagged Sf9 Insect Cell GST
Human STAT5B-197H Recombinant Human STAT5B, His-tagged E.coli His
Human STAT5B-2998H Recombinant Human STAT5B, GST-tagged E.coli GST
Human STAT5B-343H Recombinant Human STAT5B protein, His/MBP-tagged E.coli His/MBP
Human STAT5B-1851H Recombinant Human STAT5B protein, His & T7-tagged E.coli His/T7
Human STAT5B-1709HCL Recombinant Human STAT5B cell lysate N/A
Human STAT5B-2902H Recombinant Human STAT5B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human STAT5B-2118H-B Recombinant Human STAT5B Protein Pre-coupled Magnetic Beads HEK293
Human STAT5B-2118H Recombinant Human STAT5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human STAT5B-151H Recombinant Human STAT5B Protein, His-tagged Human Cells His
Human STAT5B-345H Recombinant Human STAT5B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human STAT5B-6366H Recombinant Human STAT5B Protein (Met1-Thr321), C-His tagged E.coli C-His
Human STAT5B-6367H Recombinant Human STAT5B Protein (Met1-Thr351), N-His tagged E.coli N-His
Human STAT5B-325HFL Recombinant Full Length Human STAT5B Protein, C-Flag-tagged Mammalian cells Flag
Mouse STAT5B-16112M Recombinant Mouse STAT5B Protein Mammalian Cell His
Mouse Stat5b-6173M Recombinant Mouse Stat5b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse STAT5B-8788M-B Recombinant Mouse STAT5B Protein Pre-coupled Magnetic Beads HEK293
Mouse STAT5B-8788M Recombinant Mouse STAT5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat STAT5B-5780R Recombinant Rat STAT5B Protein Mammalian Cell His
Rat STAT5B-5439R Recombinant Rat STAT5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat STAT5B-5439R-B Recombinant Rat STAT5B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey STAT5B-982C Recombinant Cynomolgus STAT5B Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey STAT5B-725C-B Recombinant Cynomolgus Monkey STAT5B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey STAT5B-725C Recombinant Cynomolgus Monkey STAT5B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human, Mouse, Rat STAT5B-2838H Recombinant Human STAT5B Protein, His-tagged E.coli N-His
Zebrafish STAT5B-1183Z Recombinant Zebrafish STAT5B Mammalian Cell His
Chicken STAT5B-6343C Recombinant Chicken STAT5B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STAT5B Related Articles
  • STAT5B Related Gene Family
  • STAT5B Related Signal Pathway

STAT5B involved in several pathways and played different roles in them. We selected most pathways STAT5B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayMTOR;GSK3AA;ERBB4A;MAPK8;MAPK1;AKT1;PAK6B;MAP2K4A;MAP2K7
Chemokine signaling pathwayPRKCD;GRK4;CCL18;CCL24;SHC2;CXCL3;ELMO1;PIK3R2;PXN
Jak-STAT signaling pathwaySTAT5A;PIK3CB;GRB2A;GM-CSF;IL12RB1;IL24;TP-1;STAT5B;IL15RA
Prolactin signaling pathwaySOCS6;MAP2K2;PIK3R1;SIRPA;FOS;LHB;SOS1;RAF1;MAPK9
Hepatitis BTLR2;STAT5A;IKBKG;IRF7;STAT1;TNF;NFATC1;PIK3R1;PIK3CB
MeaslesTBK1;IFNA6;MAP3K7;OAS3;IL6;TAB2;IFNGR2;RAB9A;AKT1
HTLV-I infectionETS1;POLD1;TGFB3;MSX2;TGFBR1;FZD9;RAN;HLA-DQA2;TGFBR2
Pathways in cancerTRAF6;IL6;FZD2;GNG5;PRKACA;FN1;NFKB1;LAMA4;PIK3R2
Viral carcinogenesisHIST1H2BB;NFKB2;PRKACB;MAPK1;CREB3L2;RBPJ;HDAC10;RB1;HNRNPK
Chronic myeloid leukemiaPIK3CB;CRKL;SOS1;CBLB;SHC4;STAT5A;SHC1;TP53;TGFB2
Acute myeloid leukemiaPIK3R5;JUP;LEF1;RELA;MAP2K2;GRB2;KRAS;RARA;MTOR

STAT5B has several biochemical functions, for example, DNA binding, chromatin binding, glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT5B itself. We selected most functions STAT5B had, and list some proteins which have the same functions with STAT5B. You can find most of the proteins on our site.

Function Related Protein
DNA bindingKIF22;CREB3;SETDB1A;EBF2;SIX6;HIST1H2BF;CREB1B;HNRPDL;SIX4
chromatin bindingCBX1;SUPT5H;YBX1;NKX6-1;HMGB3B;CBX4;CBFA2T3;SMC1A;NFATC2
glucocorticoid receptor bindingNRIP1;GRIP1;ETS2;STAT3;NR4A2;YWHAH;STAT5B;CEBPB;FKBP4
protein bindingS100P;CD209;SH3PXD2B;CDC42EP5;CRH;UNC13D;FAM103A1;CFH;SCGB2A2
protein dimerization activityBHLHE41;MNT;NPAS4;DERL3;ATP6V1C2;FBXW11B;AIFM1;NCF4;GGN
signal transducer activityTAAR8C;STAT2;PLCD3A;PLK2;GPR21;PLCB1;GJA1;VMN1R54;S1PR3A
transcription factor activity, sequence-specific DNA bindingMECP2;IRF6;NFIL3;ZFP770;NFE2L2B;ZNF35;TA;TRIM22;GCM2

STAT5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT5B here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT5B.

NMI; VCAM1; STAP2

Zhang, Q; Wang, HY; et al. Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner. JOURNAL OF IMMUNOLOGY 192:2913-2919(2014).
Atkinson, TP; et al. Immune deficiency and autoimmunity. CURRENT OPINION IN RHEUMATOLOGY 24:515-521(2012).
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