STAT5B

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STAT5B

Official Full Name Signal Transducer And Activator Of Transcription 5B
Background The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).
Synonyms STAT5B; signal transducer and activator of transcription 5B; STAT5; OTTHUMP00000198374; transcription factor STAT5B
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT5B-151H Recombinant Human STAT5B Protein, His-tagged Human Cells His
    Human STAT5B-1709HCL Recombinant Human STAT5B cell lysate N/A
    Human STAT5B-1851H Recombinant Human STAT5B protein, His & T7-tagged E.coli His/T7
    Human STAT5B-197H Recombinant Human STAT5B, His-tagged E.coli His
    Human STAT5B-2902H Recombinant Human STAT5B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT5B-2998H Recombinant Human STAT5B, GST-tagged E.coli GST
    Human STAT5B-343H Recombinant Human STAT5B protein, His/MBP-tagged E.coli His/MBP
    Human STAT5B-345H Recombinant Human STAT5B Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human STAT5B-74H Recombinant Human STAT5B, GST-tagged Sf9 Insect Cell GST
    Mouse STAT5B-16112M Recombinant Mouse STAT5B Protein Mammalian Cell His
    Mouse Stat5b-6173M Recombinant Mouse Stat5b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat STAT5B-5780R Recombinant Rat STAT5B Protein Mammalian Cell His
    Cynomolgus Monkey STAT5B-982C Recombinant Cynomolgus STAT5B Protein, His-tagged Mammalian Cell His
    Chicken STAT5B-6343C Recombinant Chicken STAT5B Mammalian Cell His
    Zebrafish STAT5B-1183Z Recombinant Zebrafish STAT5B Mammalian Cell His

    STAT5B involved in several pathways and played different roles in them. We selected most pathways STAT5B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway PIK3R1; STAT5A; BAD; PIK3R2; NRG2B; MAPK10; GSK3AA; AREGB; BTC; HBEGFB
    Chemokine signaling pathway WASL; RAP1B; CRK; CXCL5; GNG4; CCL5; PRKCZ; RAF1; PIK3R2; CRKL
    Jak-STAT signaling pathway LIFRA; Ifnlr1; TYK2; Il6ra; AOX3; PIAS4B; IL6R; IFNA13; IL9; Gh
    Prolactin signaling pathway MAPK11; SOCS7; NFKB1; ELF5; MAP2K1; PIK3CD; PPIB; NEK3; SLC2A2; MAPK10
    Hepatitis B IFIH1; TIRAP; CREB3L1; HBXIP; AKT1; BAD; PIK3CA; STAT3; IFNA8; TLR2
    Measles RCHY1; CD3G; IFNGR1; TACR1; IFNA6; CD46; Il2; IFNA14; SLAMF1; TNFRSF10C
    HTLV-I infection CD3G; PDGFA; HLA-DQA2; HLA-DMB; KRAS; TP53; STAT5A; RAN; CALR; WNT1
    Pathways in cancer BMP2; RXRB; FGF13; ARAF; MMP1A; HDAC1; Fgf15; RASSF5; GNG10; FGFR2
    Viral carcinogenesis HDAC10; PIK3CB; HLA-B; PSMC1; DLG1; PRKACA; YWHAZ; HIST3H2BB-PS; HIST1H2BG; MAPK1
    Chronic myeloid leukemia TGFB2; GAB2; HDAC1; NFKB1; CTBP2; TGFB3; IKBKG; MAPK3; PIK3R1; PTPN11
    Acute myeloid leukemia MAP2K1; JUP; IKBKG; PIM2; PIK3R1; PIK3CB; TCF7L2; CCND1; PIK3R3; BRAF

    STAT5B has several biochemical functions, for example, DNA binding, chromatin binding, glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT5B itself. We selected most functions STAT5B had, and list some proteins which have the same functions with STAT5B. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding NKX2-5; ZFP541; ATM; RAD51L3; E4F1; POLR3B; ZNF521; HOMEZB; HOXB1A; ZFP451
    chromatin binding RELA; RDBP; PYGO2; DNMT1; ATF5; PRDM11; CAPNS2; CREB3L1; ARID3C; UBTFL
    glucocorticoid receptor binding STAT3; FKBP4; EP300; ETS2; NRIP1; STAT5B; GRIP1; NR4A2; YWHAH; CEBPB
    protein binding MAP3K11; DLL4; PPM1F; IKBKB; ABI2; TLE1; CARF; CCDC137; PPP2R5B; RAB13
    protein dimerization activity TWIST1A; OLIG4; TFEC; DBI; EBF4; MESPAA; DAO; MNT; TFE3; POLR2J
    signal transducer activity JUP; MTNR1AA; OLFR15; BMX; CCR9A; MRGPRA5; GNA11; APOL3; OLFR495; OLFR867
    transcription factor activity, sequence-specific DNA binding IKZF3; NFE2L1A; SOX11B; HIRA; SIM1; NR1H4; CSRNP1; MYF6; TBX5B; ZNF311

    STAT5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT5B here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT5B.

    NMI; VCAM1; STAP2

    Zhang, Q; Wang, HY; et al. Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner. JOURNAL OF IMMUNOLOGY 192:2913-2919(2014).
    Atkinson, TP; et al. Immune deficiency and autoimmunity. CURRENT OPINION IN RHEUMATOLOGY 24:515-521(2012).

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