Recombinant Human STAT5B Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : STAT5B-345H
Product Overview : STAT5B MS Standard C13 and N15-labeled recombinant protein (NP_036580) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 89.7 kDa
AA Sequence : MAVWIQAQQLQGEALHQMQALYGQH FPIEVRHYLSQWIESQAWDSVDLDN PQENIKATQLLEGLVQELQKKAEHQ VGEDGFLLKIKLGHYATQLQNTYDR CPMELVRCIRHILYNEQRLVREANN GSSPAGSLADAMSQKHLQINQTFEE LRLVTQDTENELKKLQQTQEYFIIQ YQESLRIQAQFGPLAQLSPQERLSR ETALQQKQVSLEAWLQREAQTLQQY RVELAEKHQKTLQLLRKQQTIILDD ELIQWKRRQQLAGNGGPPEGSLDVL QSWCEKLAEIIWQNRQQIRRAEHLC QQLPIPGPVEEMLAEVNATITDIIS ALVTSTFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNDYSGEILNNC CVMEYHQATGTLSAHFRNMSLKRIK RSDRRGAESVTEEKFTILFESQFSV GGNELVFQVKTLSLPVVVIVHGSQD NNATATVLWDNAFAEPGRVPFAVPD KVLWPQLCEALNMKFKAEVQSNRGL TKENLVFLAQKLFNNSSSHLEDYSG LSVSWSQFNRENLPGRNYTFWQWFD GVMEVLKKHLKPHWNDGAILGFVNK QQAHDLLINKPDGTFLLRFSDSEIG GITIAWKFDSQERMFWNLMPFTTRD FSIRSLADRLGDLNYLIYVFPDRPK DEVYSKYYTPVPCESATAKAVDGYV KPQIKQVVPEFVNASADAGGGSATY MDQAPSPAVCPQAHYNMYPQNPDSV LDTDGDFDLEDTMDVARRVEELLGR PMDSQWIPHAQSTRTRPLEQKLISE EDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : STAT5B signal transducer and activator of transcription 5B [ Homo sapiens (human) ]
Official Symbol : STAT5B
Synonyms : STAT5B; signal transducer and activator of transcription 5B; transcription factor STAT5B; STAT5;
Gene ID : 6777
mRNA Refseq : NM_012448
Protein Refseq : NP_036580
MIM : 604260
UniProt ID : P51692

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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