| Description : |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
89.7 kDa |
| AA Sequence : |
MAVWIQAQQLQGEALHQMQALYGQH FPIEVRHYLSQWIESQAWDSVDLDN PQENIKATQLLEGLVQELQK KAEHQVGEDGFLLKIKLGHYATQLQ NTYDRCPMELVRCIRHILYNEQRLV REANNGSSPAGSLADAMSQK HLQINQTFEELRLVTQDTENELKKL QQTQEYFIIQYQESLRIQAQFGPLA QLSPQERLSRETALQQKQVS LEAWLQREAQTLQQYRVELAEKHQK TLQLLRKQQTIILDDELIQWKRRQQ LAGNGGPPEGSLDVLQSWCE KLAEIIWQNRQQIRRAEHLCQQLPI PGPVEEMLAEVNATITDIISALVTS TFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNDYSGEILNNC CVMEYHQATGTLSAHFRNMS LKRIKRSDRRGAESVTEEKFTILFE SQFSVGGNELVFQVKTLSLPVVVIV HGSQDNNATATVLWDNAFAE PGRVPFAVPDKVLWPQLCEALNMKF KAEVQSNRGLTKENLVFLAQKLFNN SSSHLEDYSGLSVSWSQFNR ENLPGRNYTFWQWFDGVMEVLKKHL KPHWNDGAILGFVNKQQAHDLLINK PDGTFLLRFSDSEIGGITIA WKFDSQERMFWNLMPFTTRDFSIRS LADRLGDLNYLIYVFPDRPKDEVYS KYYTPVPCESATAKAVDGYV KPQIKQVVPEFVNASADAGGGSATY MDQAPSPAVCPQAHYNMYPQNPDSV LDTDGDFDLEDTMDVARRVE
ELLGRPMDSQWIPHAQSTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors |
| Protein Pathways : |
Acute myeloid leukemia, Chemokine signaling pathway, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer |
