Recombinant Full Length Human STK4 Protein, C-Flag-tagged

• Cat.No.: STK4-1488HFL
• Product Overview: Recombinant Full Length Human STK4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 55.4 kDa
• AA Sequence: METVQLRNPPRRQLKKLDEDSLTKQ PEEVFDVLEKLGEGSYGSVYKAIHK ETGQIVAIKQVPVESDLQEI IKEISIMQQCDSPHVVKYYGSYFKN TDLWIVMEYCGAGSVSDIIRLRNKT LTEDEIATILQSTLKGLEYL HFMRKIHRDIKAGNILLNTEGHAKL ADFGVAGQLTDTMAKRNTVIGTPFW MAPEVIQEIGYNCVADIWSL GITAIEMAEGKPPYADIHPMRAIFM IPTNPPPTFRKPELWSDNFTDFVKQ CLVKSPEQRATATQLLQHPF VRSAKGVSILRDLINEAMDVKLKRQ ESQQREVDQDDEENSEEDEMDSGTM VRAVGDEMGTVRVASTMTDG ANTMIEHDDTLPSQLGTMVINAEDE EEEGTMKRRDETMQPAKPSFLEYFE QKEKENQINSFGKSVPGPLK NSSDWKIPQDGDYEFLKSWTVEDLQ KRLLALDPMMEQEIEEIRQKYQSKR QPILDAIEAKKRRQQNFTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway, Non-small cell lung cancer, Pathways in cancer

Gene Information

• Gene Name: STK4 serine/threonine kinase 4 [ Homo sapiens (human) ]
• Official Symbol: STK4
• Synonyms: KRS2; MST1; YSK3
• Gene ID: 6789
• mRNA Refseq: NM_006282.5
• Protein Refseq: NP_006273.1
• MIM: 604965
• UniProt ID: Q13043