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TLR10

Official Full Name

toll-like receptor 10
Overview

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
Synonyms

TLR10; toll-like receptor 10; CD290; MGC104967; MGC126398; MGC126399; OTTHUMP00000158729; CD290 antigen; TLR10_HUMAN; Toll like receptor 10; OTTHUMP00000218160; OTTHUMP00000218161; OTTHUMP00000218162;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells

Tag

His
Fc
Avi
GST
Myc
SUMO
T7
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TLR10-2080H	Recombinant Human TLR10 protein, His & GST-tagged	E.coli	His&GST	Trp617~Glu784 (Accession # Q9BXR5)	Inquiry
Human	TLR10-1046HCL	Recombinant Human TLR10 293 Cell Lysate	HEK293	Non		Inquiry
Human	TLR10-2399H	Recombinant Human TLR10 protein, His-tagged	E.coli	His	20-576aa	Inquiry
Human	TLR10-1476H	Recombinant Human TLR10 Protein (Lys622-Asn776), N-His tagged	E.coli	His	Lys622-Asn776	Inquiry
Human	TLR10-5197H	Recombinant Human TLR10 Protein (Met1-Thr576), C-His tagged	Mammalian cells	His	Met1-Thr576	Inquiry
Human	TLR10-2400H	Recombinant Human TLR10 protein, His-SUMO & Myc-tagged	E.coli	His&Myc&SUMO	20-576aa	Inquiry
Rat	Tlr10-2081R	Recombinant Rat Tlr10 protein, His & T7-tagged	E.coli	His&T7	Trp20~His250 (Accession # C0LSK8)	Inquiry
Rhesus Macaque	TLR10-4730R	Recombinant Rhesus monkey TLR10 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TLR10-4544R	Recombinant Rhesus Macaque TLR10 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	TLR10-4544R-B	Recombinant Rhesus Macaque TLR10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

TLR10 involved in several pathways and played different roles in them. We selected most pathways TLR10 participated on our site, such as Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Disease	GCKR;BANF1;HEY2;LRRFIP1;TCEA1;AP1G1;TNKS2;MMADHC;KPNA3
Diseases associated with the TLR signaling cascade	TICAM1;TLR6;TLR10;TIRAP
Diseases of Immune System	TIRAP;TLR6;TLR10
IRAK4 deficiency (TLR5)
Immune System	IFI6;KLHL20;STUB1;FBXO17;TRIM48;IFIT8;CTSK;MB21D1;PANX1
Innate Immune System	CLEC6A;CD300LB;Txn1;CTS7;CFHL2;DHX9;NLRP4B;DEFB119;NOD1
MyD88 cascade initiated on plasma membrane	ALCAMB;AGER;S100A12;PELI3;PELI2;PELI1;CHST13;TLR10;DHX9
Toll Like Receptor 10 (TLR10) Cascade

TLR10 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR10 itself. We selected most functions TLR10 had, and list some proteins which have the same functions with TLR10. You can find most of the proteins on our site.

Function	Related Protein
transmembrane signaling receptor activity	TLR2-1;OR4D6;SELE;OR4C13;CD69;IL1R1;TNFRSF10D;FZD8B;ADCYAP1R1A

TLR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR10.

Research Area

Immune Regulatory Molecules on Endothelial Cells

T Cell Antigen Recognition

Neuroinflammation

Toll-Like Receptors (TLRs)

NOD-like Receptors and the Inflammasome

Matas-Cobos, AM; Redondo-Cerezo, E; et al. The Role of Toll-Like Receptor Polymorphisms in Acute Pancreatitis Occurrence and Severity. PANCREAS 44:429-433(2015).

Skipor, J; Szczepkowska, A; et al. PROFILE OF TOLL-LIKE RECEPTOR mRNA EXPRESSION IN THE CHOROID PLEXUS IN ADULT EWES. ACTA VETERINARIA HUNGARICA 63:69-78(2015).