TLR10

  • Official Full Name

    toll-like receptor 10

  • Overview

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
  • Synonyms

    TLR10; toll-like receptor 10; CD290; MGC104967; MGC126398; MGC126399; OTTHUMP00000158729; CD290 antigen; TLR10_HUMAN; Toll like receptor 10; OTTHUMP00000218160; OTTHUMP00000218161; OTTHUMP00000218162;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR10-2080H Recombinant Human TLR10 protein, His & GST-tagged E.coli His/GST Trp617~Glu784 (Accession # Q9BXR5)
Human TLR10-1046HCL Recombinant Human TLR10 293 Cell Lysate HEK293 N/A
Human TLR10-2399H Recombinant Human TLR10 protein, His-tagged E.coli His 20-576aa
Human TLR10-1476H Recombinant Human TLR10 Protein (Lys622-Asn776), N-His tagged E.coli N-His Lys622-Asn776
Human TLR10-5197H Recombinant Human TLR10 Protein (Met1-Thr576), C-His tagged Mammalian cells C-His Met1-Thr576
Human TLR10-2400H Recombinant Human TLR10 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 20-576aa
Rat Tlr10-2081R Recombinant Rat Tlr10 protein, His & T7-tagged E.coli His/T7 Trp20~His250 (Accession # C0LSK8)
Rhesus Macaque TLR10-4730R Recombinant Rhesus monkey TLR10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR10-4544R Recombinant Rhesus Macaque TLR10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR10-4544R-B Recombinant Rhesus Macaque TLR10 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLR10 Related Articles
  • TLR10 Related Research Area

TLR10 involved in several pathways and played different roles in them. We selected most pathways TLR10 participated on our site, such as Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DiseaseRDBP;CCDC59;CDC37;RLBP1;ACAN;STRA6;FDXR;RPL35;SUPT4H1
Diseases associated with the TLR signaling cascadeTIRAP;TLR10;TLR6;TICAM1
Diseases of Immune SystemTIRAP;TLR6;TLR10
IRAK4 deficiency (TLR5)
Immune SystemDEFA1;POLR3F;DYNC1LI2;UBE2J2;EIF4E3;EVL;USP18;DYNLL2;UBA5
Innate Immune SystemFCN3;BTR06;ABI1A;MGC174152;FCN2;PELI3;LRRFIP1;DEFB103A;CRP
MyD88 cascade initiated on plasma membranePELI2;TLR10;PELI3;PELI1;AGER;ALCAMB;S100A12;TNIP2;DHX9
Toll Like Receptor 10 (TLR10) Cascade

TLR10 has several biochemical functions, for example, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR10 itself. We selected most functions TLR10 had, and list some proteins which have the same functions with TLR10. You can find most of the proteins on our site.

Function Related Protein
transmembrane signaling receptor activityOR4C12;GHRHR2;CD5;TLR18;LAG3;TLR2-1;THBD;OR12D3;DARC

TLR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR10.

Matas-Cobos, AM; Redondo-Cerezo, E; et al. The Role of Toll-Like Receptor Polymorphisms in Acute Pancreatitis Occurrence and Severity. PANCREAS 44:429-433(2015).
Skipor, J; Szczepkowska, A; et al. PROFILE OF TOLL-LIKE RECEPTOR mRNA EXPRESSION IN THE CHOROID PLEXUS IN ADULT EWES. ACTA VETERINARIA HUNGARICA 63:69-78(2015).
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