Recombinant Human TNFRSF10A, Fc-tagged

• Cat.No.: TNFRSF10A-27024TH
• Product Overview: Recombinant fusion protein comprising the extracellular domain (aa 1/238)of Human DR4 and Fc portion of human IgG1.Produced in HEK 293 cells.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
• Conjugation: Fc
• Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
• Form: Lyophilised:Reconstitute with 50 μl sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial. After reconsitution short term store at 4
• Purity: Protein A purified
• Storage buffer: Preservative: NoneConstituents: PBS
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 death domain.Contains 3 TNFR-Cys repeats.

Gene Information

• Gene Name: TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens ]
• Official Symbol: TNFRSF10A
• Synonyms: TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1
• Gene ID: 8797
• mRNA Refseq: NM_003844
• Protein Refseq: NP_003835
• MIM: 603611
• Uniprot ID: O00220
• Chromosome Location: 8p21
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem
• Function: TRAIL binding; cysteine-type endopeptidase activator activity involved in apoptotic process; death receptor activity; protein binding; receptor activity