TNNT2
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Official Full Name
troponin T type 2 (cardiac)
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Overview
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008] -
Synonyms
TNNT2; troponin T type 2 (cardiac); CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Human
- Mouse
- Pig
- Rat
- E.coli
- Heart
- HEK293
- HEK293T
- Human Cardiac
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- His (Fc)
- Avi
- GST
- His|GST
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TNNT2 Related Research Area
TNNT2 involved in several pathways and played different roles in them. We selected most pathways TNNT2 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | CACNB4;ATP1B2B;FXYD2;ATP1B2;COX6B1;TPM2;ATP1A2A;COX7C;UQCRQ |
| Adrenergic signaling in cardiomyocytes | ATP1A2;CAMK2G1;GNAI3;PRKACA;GNAI2;SLC9A1;CACNG3;ADCY1;PPP2R5B |
TNNT2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TNNT2 itself. We selected most functions TNNT2 had, and list some proteins which have the same functions with TNNT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
TNNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNT2.
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