tp73

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tp73

Official Full Name tumor protein p73
Background The p73 gene has been mapped to the short arm of chromosome 1, position 1p36, a region frequently deleted in neuroblastomas. Allelic loss at 1p36 has also been reported in melanoma, breast carcinoma and colon carcinoma. The p73 transcript is differentially spliced to generate 2 mRNAs that code for the 2 isoforms of p73, p73alpha and p73beta. There is significant sequence homology between amino acid residues in the p73 isoforms and the DNA-binding, transactivation and oligomerization domains of p53. p73 activates p21WAF1 in transfected SK-N-AS cells and transfected SAOS2 cells, suggesting a role for p73 as a transcription factor. In similar transfection experiments, p73 was reported to induce apoptosis in SAOS2 and BHK cells.
Synonyms TP73; tumor protein p73; P73; p53-related protein; p53-like transcription factor
    • Species :
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TP73-4281H Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TP73-6327H Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TP73-30454TH Recombinant Human TP73 Sf9 Insect Cell N/A
    Human TP73-30577TH Recombinant Human TP73 Insect Cell N/A
    Human TP73-30579TH Recombinant Human TP73 Sf9 Insect Cell N/A
    Human TP73-328H Recombinant Human Tumor Protein P73, GST-tagged Sf9 Insect Cell GST
    Human TP73-329H Recombinant Human Tumor Protein P73, GST-tagged Sf9 Insect Cell GST
    Human TP73-330H Recombinant Human Tumor Protein P73, GST-tagged Sf9 Insect Cell GST
    Human TP73-853HCL Recombinant Human TP73 293 Cell Lysate HEK293 N/A
    Zebrafish TP73-9700Z Recombinant Zebrafish TP73 Mammalian Cell His

    tp73 involved in several pathways and played different roles in them. We selected most pathways tp73 participated on our site, such as p signaling pathway, Hippo signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with tp73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway APAF1; MDM2; CASP8; RRM2; PTENB; BBC3; CCNG1; CCNE1; EI24; PERP
    Hippo signaling pathway TEAD2; PPP2R2D; BMP4; LEF1; Fzd4; TCF7; TGFBR1; YWHAH; PPP2CA; TGFB3
    Neurotrophin signaling pathway ARHGDIB; SHC1; MAP3K3; CALML5; ZFP110; RAF1; MAPKAPK2; SHC3; MAP2K5; MAPK10
    Measles EIF3H; HSPA1A; EIF2AK1; AKT1; Il2; HSPA1B; IFNA10; OAS2; CD209C; IFNGR2

    tp73 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tp73 itself. We selected most functions tp73 had, and list some proteins which have the same functions with tp73. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding FOXL2; NR2C1; CARF; PAX8; HLTF; ZNF460; CC2D1A; GRHL1; ELF1; TBX20
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXH1; SP2; SIM1; NPAS1; SOX21; MAZ; GCM1; RUNX2; PEG3; SOX14
    chromatin binding TRP63; HMG20A; MECP2; RELA; ORC1L; ARNTL1B; IFT74; STAG2; GLI1; ZMYND11
    damaged DNA binding TRP53; POLH; MPG; RAD18; ERCC4; NEIL1; TP53; RPS3; MGMT; APEX1
    double-stranded DNA binding RAD51B; PYDC3; KLF6; RAD51D; MEN1; DDX58; TDP1; FBXO18; SATB1; HNRPDL
    identical protein binding BCL2L1; EID3; KCNH2; TRA@; NOD1; HNRNPC; APIP; RIPK3; VWA2; APOE
    metal ion binding ZNF728; KEL; BA1; ZFPM1; ZBTB8B; TRIM43B; CARS; PPP3CC; ACSM2B; NDUFS2
    p53 binding CDK5; CDKN2AIP; STK11; RNF34; TP73; ZMAT3; GSK3B; TAF1; ZNF385D; TRP53
    protein binding RPS2; SDPR; PHF8; USP18; MTX2; CAMLG; IYD; VAT1L; TMED10; RUSC1
    protein kinase binding CCND3; PPP1R12B; TBC1D14; SREBF1; FGF19; TP73; H2AFY; AP1B1; GCSAM; FGR
    transcription factor activity, sequence-specific DNA binding ZFP287; ZNF274; CBFA2T3; GLI4; RFX5; ZNF484; ZFP551; PPARAB; ASCL2; TFDP1A
    transcription factor binding KEAP1B; PIANP; MED6; CREBBP; MED12; PSMD10; NAB2; ARNT; PRICKLE1; APBB1
    transcription regulatory region DNA binding CARM1; CCNT1; MTERFD3; NKX3; NR1D1; RCOR1; IKZF4; ZNF831; HDAC1; GATA4
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MYBL1; RFX4; TCF4; PLSCR1; NR4A3; PPARA; SOX9; ETV4; ESR1; EBF2

    tp73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tp73 here. Most of them are supplied by our site. Hope this information will be useful for your research of tp73.

    HSPA9; AURKA

    Santoni, M; Amantini, C; et al. Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. BRITISH JOURNAL OF CANCER 109:1040-1050(2013).
    Casabonne, D; Reina, O; et al. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:323-327(2011).

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