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TP73

Official Full Name

tumor protein p73
Overview

The p73 gene has been mapped to the short arm of chromosome 1, position 1p36, a region frequently deleted in neuroblastomas. Allelic loss at 1p36 has also been reported in melanoma, breast carcinoma and colon carcinoma. The p73 transcript is differentially spliced to generate 2 mRNAs that code for the 2 isoforms of p73, p73alpha and p73beta. There is significant sequence homology between amino acid residues in the p73 isoforms and the DNA-binding, transactivation and oligomerization domains of p53. p73 activates p21WAF1 in transfected SK-N-AS cells and transfected SAOS2 cells, suggesting a role for p73 as a transcription factor. In similar transfection experiments, p73 was reported to induce apoptosis in SAOS2 and BHK cells.
Synonyms

TP73; tumor protein p73; P73; p53-related protein; p53-like transcription factor;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E. coli
HEK293
HEK293T
Insect Cell
Mammalian Cell
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TP73-30579TH	Recombinant Human TP73	Sf9 Insect Cell	N/A	499 amino acids	Inquiry
Human	TP73-329H	Recombinant Human Tumor Protein P73, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	TP73-30577TH	Recombinant Human TP73	Insect Cell	N/A	636 amino acids	Inquiry
Human	TP73-30454TH	Recombinant Human TP73	Sf9 Insect Cell	N/A	476 amino acids	Inquiry
Human	TP73-330H	Recombinant Human Tumor Protein P73, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	TP73-328H	Recombinant Human Tumor Protein P73, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	TP73-853HCL	Recombinant Human TP73 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TP73-6327H	Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	TP73-4281H	Recombinant Human TP73 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	TP73-2463H	Recombinant Human TP73 protein(261-350 aa), C-His-tagged	E. coli	C-His	261-350 aa	Inquiry
Zebrafish	TP73-9700Z	Recombinant Zebrafish TP73	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TP73 Related Articles
TP73 Related Signal Pathway

TP73 involved in several pathways and played different roles in them. We selected most pathways TP73 participated on our site, such as p signaling pathway, Hippo signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TP73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
p signaling pathway	RPRMA;GADD45B;Casp3;TP53AIP1;CCNB2;THBS1;SESN2;BAX;IGFBP3
Hippo signaling pathway	BMP2;FZD7;BMPR1A;WNT8B;GDF6;BMPR2;PARD3;WNT9B;WNT9A
Neurotrophin signaling pathway	MAPK10;ARHGDIG;ZFP110;TRP53;NTF3;IRAK2;RPS6KA3;NGFR;PLCG1
Measles	TYK2;CD3G;TLR9;PIK3CG;IFNA6;TNFRSF10C;CD209A;CD209B;IRAK1

TP73 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TP73 itself. We selected most functions TP73 had, and list some proteins which have the same functions with TP73. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA binding	CEBPB;IRF1;CEBPA;MEF2B;GMEB2;ZBTB7A;PPARA;CC2D1A;EP300
RNA polymerase II transcription factor activity, sequence-specific DNA binding	ELK4;SIM1B;SOX30;ERG;PAX6;FOXQ1B;ELF2B;ZNF434;EPAS1
chromatin binding	CBFA2T3;BRD2;NR5A5;PRIMPOL;ZEB1;HHEX;STAG1;PHF21A;ZKSCAN3
damaged DNA binding	DCLRE1C;MPG;TRP63;ERCC4;FEN1;POLI;OGG1;TRPC2;RBBP8
double-stranded DNA binding	AIM2;RAD51L1;TP73;RAD51L3;SETMAR;SP8B;MCM10;AFF3;SATB1
identical protein binding	C1S;ATF3;ATXN10;NPR2;CLDN23;KCNH2;STAT6;STK4;APOE
metal ion binding	TPP1;CPPED1;ZNF728;RNF34B;ZNF672;LMAN2L;PRICKLE2A;IKZF5;NR1D2B
p53 binding	EP300;KDM1A;HTT;SMYD2;STK11;USP10;CDKN2AIP;TRP53;ZNF385C
protein binding	OSR2;UBE2F;C8orf48;ELOVL6;ZHX3;ITCH;ABCF3;ETV7;PBRM1
protein kinase binding	TTN;PTPRJ;ACVRL1;PRKAG1;PRKAG3;PTPRC;LSM2;FAM83E;NIPAL1
transcription factor activity, sequence-specific DNA binding	MYCLA;CEBP1;ZNF484;ELF2A;FEV;SOX5;SPI1B;POU3F3A;MYT1LA
transcription factor binding	AIP;TAF7;KCTD1;Trl;ERCC3;PURA;LMO4;SP100;NIF3L1
transcription regulatory region DNA binding	AIRE;ZNF174;KCNA3;SALL3;GRHL2B;PRDM5;XRCC5;PHB;GATA5
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	HOXA10;PAX5;CREB3L2;NKX2-8;ZIC3;HEYL;ALS2CR8;MYOCD;SIX4

TP73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TP73 here. Most of them are supplied by our site. Hope this information will be useful for your research of TP73.

HSPA9; AURKA

Santoni, M; Amantini, C; et al. Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. BRITISH JOURNAL OF CANCER 109:1040-1050(2013).

Casabonne, D; Reina, O; et al. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 96:323-327(2011).