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TRAF3

Official Full Name

TNF receptor-associated factor 3
Overview

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
Synonyms

TRAF3; TNF receptor-associated factor 3; LAP1; CAP-1; CRAF1; CD40bp; CD40 binding protein; CD40 associated protein 1; LMP1-associated protein 1; CD40 receptor associated factor 1; CAP 1; CD40-binding protein; LAP 1; MIPT3; TRAF3_HUMAN;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
Myc
DDK
Myc|DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRAF3-3385H	Recombinant Human TRAF3, GST-tagged	Wheat Germ	GST		$498 / 5µg $598 / 10µg
Human	TRAF3-3384H	Recombinant Human TRAF3, GST-tagged	E.coli	GST	6-351aa	$319 / 25ug
Human	TRAF3-3386H	Recombinant Human TRAF3, GST-tagged	Wheat Germ	GST		Inquiry
Human	TRAF3-3387H	Recombinant Human TRAF3, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	TRAF3-823HCL	Recombinant Human TRAF3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TRAF3-822HCL	Recombinant Human TRAF3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TRAF3-5407HFL	Recombinant Full Length Human TRAF3, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	TRAF3-4611H	Recombinant Human TRAF3 protein	E.coli	N/A	1-568aa	Inquiry
Human	TRAF3-6510H	Recombinant Human TRAF3 Protein (Lys6-Lys351), N-His tagged	E.coli	N-His	Lys6-Lys351	Inquiry
Human	TRAF3-1348H	Recombinant Human TRAF3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	TRAF3-3617H	Recombinant Human TRAF3 protein, His-tagged	E.coli	His	1-568aa	Inquiry
Human	TRAF3-530HF	Recombinant Full Length Human TRAF3 Protein, GST-tagged	In Vitro Cell Free System	GST	568 amino acids	Inquiry
Mouse	Traf3-6618M	Recombinant Mouse Traf3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	TRAF3-954Z	Recombinant Zebrafish TRAF3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRAF3 Related Articles
TRAF3 Related Research Area

TRAF3 involved in several pathways and played different roles in them. We selected most pathways TRAF3 participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NF-kappa B signaling pathway	TNFRSF1A;LAT;NFKBIA;RELB;CCL13;CD14;MAP3K7IP3;TRAF1;TRAF6
Toll-like receptor signaling pathway	CXCL11;IFNA6;MAPK12B;FADD;IFNA10;TLR7;MAPK8A;IFNAR2;TLR3
RIG-I-like receptor signaling pathway	TBK1;TRIM25;IL-8;RNF207B;IFNA13;MAPK10;IFNA14;CASP8;IFNPHI3
TNF signaling pathway	FADD;CREB3L3;AKT1;MAPK1;PIK3CD;PIK3R3;DNM1L;AKT2;PIK3CG
Hepatitis C	AKT1;IFNA4;EIF3E;IFNA8;MAPK12;PIK3CG;MAPK9;MAPK13;AKT2
Herpes simplex infection	NFKBIB;TNFRSF14;MAPK8A;NFKBIAA;HLA-DQA2;SP100;EEF1D;CD74;C1QBP
Epstein-Barr virus infection	TRADD;RELB;TRP53;SFPI1;EIF2AK1;MAP2K6;CD58;MAP3K7;POLR2J2
Pathways in cancer	TCEB1;TCEB2;VEGFB;MDM2;PLCB1;GNG4;CKS2;MAPK9;ITGA2B
Viral carcinogenesis	HIST1H2BD;RHOA;SYK;BAD;HDAC10;HIST1H4A;ACTN4;GTF2E1;HIST1H2BP
Small cell lung cancer	IKBKG;CKS2;ITGA2;LAMA2;LAMB3;TRAF5;PIK3R1;PIK3CB;LAMA5

TRAF3 has several biochemical functions, for example, ligase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF3 itself. We selected most functions TRAF3 had, and list some proteins which have the same functions with TRAF3. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	ATG3;UBE2L3A;HECTD2;TRIM2;RNF114;GLULA;MIB1;ACSM2;TRIM9
protein binding	UPF1;IRF7;TSPAN1;STAU2;CLUAP1;TBX5A;GOSR2;MRPL44;ALOX12B
protein kinase binding	TPX2;Fert2;CLTC;FBXW5;SPDYB;JIP1;HDAC7A;PRC1;TENC1
protein phosphatase binding	KAT2A;RPA2;PPP1R3G;MAPK14;STAT3;MAP3K5;STAT6;PPP6R1;EGFR
signal transducer activity	GNA11;LITAF;TAS2R120;TACR3L;TAAR9;MRGPRG;NDFIP1;PLK2;TRIM13
thioesterase binding	CALM2;TRAF6;RAC1;TRAF3;CDC42;CALM;TRAF1;ARF6;TRAF5
tumor necrosis factor receptor binding	TNFSF8;TNFSF9;TNFSF10;FADD;TNFSF11;TRADD;TNF;CD70;TRIM37
ubiquitin protein ligase binding	TUBB;EIF4E2;UBE2NB;UBE2J2;CASP8;UBE2V1;UBE2L3;DAXX;UBE2A
ubiquitin-protein transferase activity	HECW2;UBR3;LRSAM1;WDSUB1;SIAH1;RNF141;RFWD3;RNF6;STUB1
zinc ion binding	RAPSN;MSRB3;POLR2K;RUNX1;LIG3;PPARA;PDZRN3B;PDZRN4;PDZRN3

TRAF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF3.

TANK; TRAF3IP1; RIPK2; CD40

Chang, JH; Hu, HB; et al. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. JOURNAL OF EXPERIMENTAL MEDICINE 211:137-151(2014).

Xu, HY; He, XZ; et al. miR-338-5p indirectly regulate BAFF signal by targeting TRAF3 during renal allograft antibody-mediated rejection. JOURNAL OF IMMUNOLOGY 190:-(2013).

IL-17 Signaling Related Molecules

E3 Ubiquitin Ligases