Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

TTN

  • Official Full Name

    titin

  • Overview

    This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a;N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions;of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and;lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin;repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line;and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin;also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of;contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes.;Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the;I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in;elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types.;Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are;produced in patients with the autoimmune disease scleroderma.
  • Synonyms

    TTN; titin; cardiomyopathy, dilated 1G (autosomal dominant) , CMD1G; CMH9; CMPD4; FLJ32040; LGMD2J; MYLK5; TMD; connectin; rhabdomyosarcoma antigen MU-RMS-40.14; CMD1G; EOMFC; HMERF; FLJ26020; FLJ26409; FLJ34413; FLJ39564; FLJ43066; DKFZp451N061;

  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • GST
  • GST|His
  • His
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TTN-1780H Recombinant Human TTN protein, His-tagged E.coli His Pro33779~Gln34025 (Accession # Q8WZ42)
Human TTN-25H Recombinant Human TTN, GST-tagged Wheat Germ GST/His
Human TTN-705H Recombinant Human Titin E.coli N/A
Human TTN-27H Recombinant Human TTN, GST-tagged Wheat Germ GST
Human TTN-26H Recombinant Human TTN, GST-tagged Wheat Germ GST
Human TTN-1391H Recombinant Human TTN Protein, His-tagged E.coli His
Human TTN-3629H Recombinant Human TTN protein, His&Myc-tagged E.coli His&Myc 14257-14543aa
Human TTN-301647H Recombinant Human TTN protein, GST-tagged E.coli GST Met33738-Lys33969
Mouse Ttn-507M Recombinant Mouse Ttn Protein, His-tagged E.coli His Thr34750~Ser34990
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TTN Related Articles

TTN involved in several pathways and played different roles in them. We selected most pathways TTN participated on our site, such as Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with TTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)CACNA2D3;TNNC1;DES;CACNG1;ITGB3;ITGB8;CACNA2D1;ITGAV;CACNG4
Dilated cardiomyopathyITGA2B;ACTB;ITGB1;Adcy4;CACNB1;ITGB5;TPM4;ITGA2;CACNB3

TTN has several biochemical functions, for example, ATP binding, actin filament binding, actinin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TTN itself. We selected most functions TTN had, and list some proteins which have the same functions with TTN. You can find most of the proteins on our site.

Function Related Protein
ATP bindingILF2;NUAK1;DNAJA3;TOR1;UPF1;ADCY8;CCT5;HSC70;RECQL5
actin filament bindingPLS1;TAGLN3B;USH1C;DBNLB;WIPF2B;SHROOM2;SHROOM4;TLN2A;WIPF3
actinin bindingRELA;PROM1;NFKB1;MICALL2;CSRP3;TTN;PDLIM5;PKD2
calcium ion bindingCANT1B;CPS1;CDH10;PCDHGB1;FKBP10B;ANXA11B;HMCN1;GUCA1C;OTOF
calmodulin bindingPPP3CC;TRPV5;MYO1C;PPP3CA;SPATA17;KCNQ3;CNGA2;RGS4;NDUFAF4
enzyme bindingCD40;HSPA2;PDE4D;HIST1H2AN;HDAC1;CYB5A;DAOA;KAT8;PARK2
identical protein bindingINHBA;CEP72;PRDX3;SOD2;VPS41;SDCBP;C1QTNF9;MAP1S;VIL1
muscle alpha-actinin bindingNRAP;TTN;PDLIM2;LDB3;MYPN;PKD2L1;PKD2;PALLD
protease bindingLDLR;C10orf2;ADAM8A;BRCA2;ITGAV;Casp3;TNFAIP3;MBP;CRADD
protein bindingWBP1;C8orf48;SENP5;TCF12;MMP2;AMMECR1;BMP1A;WDTC1;IWS1
protein kinase bindingTRAF6;MAP3K1;EEF1A1;RELA;TPRKB;CEP68;AGTR1A;GRB2;TELO2
protein self-associationCCDC88C;TMEM190;TMEM43;TTN;AXIN1;CTSB;NKX3-1;SYP;ZKSCAN17
protein serine/threonine kinase activitySTK3;TAOK2;NLK;CSNK1E;CSNK1D;SYK;CAMK2D2;STK17B;CDK11A
protein tyrosine kinase activityDYRK4;ZAP70;TYRO3;FER;HCK;EPHA2A;PTK7A;RET;ERBB2
structural constituent of muscleMYOT;PDLIM3;ANKRD2;MYL1;MYL9;MYBPC3;SMTN;SORBS2;JPH1
structural molecule activity conferring elasticityTTN;AHNAK
telethonin bindingKCNE1;BMP10;MYOZ2;CSRP3;TTN

TTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTN here. Most of them are supplied by our site. Hope this information will be useful for your research of TTN.

Matsumoto, Y; Zhang, Q; et al. Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin alpha 5 beta 1 and Matrix Metalloproteinase 9. JOURNAL OF BIOLOGICAL CHEMISTRY 288:24264-24276(2013).
Cutino-Avila, B; Cunill-Semanat, E; et al. Synthesis of Tetanus Toxoid-Sepharose CL 4B derivatives by Rational Design. 5TH LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2011): SUSTAINABLE TECHNOLOGIES FOR THE HEALTH OF ALL, PTS 1 AND 2 33:160-163(2013).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All TTN Products

Required fields are marked with *

My Review for All TTN Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends