tuba1a

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tuba1a

Official Full Name tubulin, alpha 1a
Background Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
Synonyms TUBA1A; tubulin, alpha 1a; tubulin alpha-1A chain; B ALPHA 1; FLJ25113; TUBA3; tubulin; alpha; brain specific; hum-a-tub1; hum-a-tub2; alpha-tubulin 3; tubulin, alpha 3; tubulin B-alpha-1; tubulin alpha-3 chain; tubulin, alpha, brain-specific; LIS3; B-ALP
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TUBA1A-106H Recombinant Human TUBA1A, GST-tagged Wheat Germ GST
    Human TUBA1A-107H Recombinant Human TUBA1A, GST-tagged Wheat Germ GST
    Human TUBA1A-16H Recombinant Human TUBA1A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TUBA1A-17H Recombinant Human TUBA1A protein, GST-tagged Wheat Germ GST
    Human TUBA1A-18H Recombinant Human TUBA1A protein, GST-tagged Wheat Germ GST
    Human TUBA1A-31628TH Recombinant Human TUBA1A, His-tagged E.coli His
    Human TUBA1A-3184H Recombinant Human TUBA1A protein, His-tagged E.coli His
    Human TUBA1A-5777H Recombinant Human TUBA1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TUBA1A-662HCL Recombinant Human TUBA1A 293 Cell Lysate HEK293 N/A
    Mouse TUBA1A-17608M Recombinant Mouse TUBA1A Protein Mammalian Cell His
    Rat TUBA1A-6354R Recombinant Rat TUBA1A Protein Mammalian Cell His

    tuba1a involved in several pathways and played different roles in them. We selected most pathways tuba1a participated on our site, such as Phagosome, Gap junction, Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with tuba1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome STX12; DYNC1LI2; TUBA3A; FCGR2C; ATP6V1A; NOX3; FCGR1; BF1; FCGR2A; HBL4
    Gap junction GNAI1; MAPK3; PDGFC; PLCB2; TUBA3B; PRKCBB; GRM5; HRASA; MAPK7; GNA15.4
    Pathogenic Escherichia coli infection EZR; TUBB2A; RHOA; NCK2; LY96; TLR4; YWHAZ; TUBA8; HCLS1; KRT18

    tuba1a has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tuba1a itself. We selected most functions tuba1a had, and list some proteins which have the same functions with tuba1a. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding RASL12; EIF5; TUBB2; GNAI2; DIRAS2; RAB17; SEPT7B; ARHGAP35; RASL11A; RASD1
    GTPase activity GNAI2; RALAA; GUF1; TBCC; GNAO1; RAB3DB; RAB11B; GFM1; RAB40AL; ARL2
    protein binding PPP1R2P3; DERL3; URM1; PPM1K; OTOF; DEDD2; DIS3; TNFRSF12A; TCF3; C7orf49
    protein domain specific binding NEFL; HOXB1; STX1B; NFASC; SLC34A2; EZR; NEDD4; CHMP2B; TNFAIP1; TUBB
    structural constituent of cytoskeleton TNNT2A; TUBB2B; TPM1; TUBA1L2; ACTL6B; BKJ; CYLC2; TUBA3E; TUBA8L2; TUBA8L3
    structural molecule activity SEPT4; KRT222; KRT93; CLTB; CLDN22; KRT80; KRT72-PS; CLTCA; KLHL3; CLDN3

    tuba1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tuba1a here. Most of them are supplied by our site. Hope this information will be useful for your research of tuba1a.

    EGFR; CYLD; LRRK2; HDAC6; HTRA2; MYO10; LTA; LGALS2; JUN; NCK1; NFKBIA

    Romaniello, R; Arrigoni, F; et al. Mutations in alpha- and beta-tubulin encoding genes: Implications in brain malformations. BRAIN & DEVELOPMENT 37:273-280(2015).
    McMichael, G; Bainbridge, MN; et al. Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy. MOLECULAR PSYCHIATRY 20:176-182(2015).

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