• Official Full Name

    thioredoxin reductase 2

  • Overview

    The reduced form of thioredoxin serves as a hydrogen donor, contributes to the up-regulation of various transcription factors and binds to and inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial protein. TrxR expression is induced in several tumors.
  • Synonyms

    TXNRD2; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase beta; TR; TR3; TRXR2; thioredoxin reductase 3; thioredoxin reductase TR3; SELZ; TR-BETA;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Diagnostic Enzyme
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TXNRD2-31640TH Recombinant Human TXNRD2, His-tagged E.coli His
Human TXNRD2-3507H Recombinant Human TXNRD2 protein, His-tagged E.coli His 176-524 aa
Human TXNRD2-20H Recombinant Human TXNRD2 Protein, 488 residues 488 residues
Human TXNRD2-4903H Recombinant Human TXNRD2 protein, His-SUMO-tagged E.coli His-SUMO 37-524aa
Human TXNRD2-22H Recombinant Human TXNRD2 Protein Tag Free
Mouse TXNRD2-17668M Recombinant Mouse TXNRD2 Protein Mammalian Cell His
Mouse TXNRD2-9794M Recombinant Mouse TXNRD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TXNRD2-9794M-B Recombinant Mouse TXNRD2 Protein Pre-coupled Magnetic Beads HEK293
Rat TXNRD2-6379R Recombinant Rat TXNRD2 Protein Mammalian Cell His
Rat TXNRD2-6035R Recombinant Rat TXNRD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Txnrd2-15R Recombinant Rat Txnrd2 Protein, 490 residues 490 residues
Rat TXNRD2-6035R-B Recombinant Rat TXNRD2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TXNRD2-1067C Recombinant Cynomolgus TXNRD2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TXNRD2-810C Recombinant Cynomolgus Monkey TXNRD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TXNRD2-810C-B Recombinant Cynomolgus Monkey TXNRD2 Protein Pre-coupled Magnetic Beads HEK293
Chicken TXNRD2-3833C Recombinant Chicken TXNRD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TXNRD2 involved in several pathways and played different roles in them. We selected most pathways TXNRD2 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Oxidative Stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TXNRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular responses to stressPOT1A;HMGA1-RS1;ATG101;CEBPB;TXN;DYNLL2;ACD;RRAGA;DPF1
Detoxification of Reactive Oxygen SpeciesTXN;Txn1;PRDX2;TXN2;PRDX3;TXNRD2
Pyrimidine metabolismCDA;UCK2B;UPP2;POLD1;POLR1C;NT5C2B;TRR1;PNP6;UCKL1
Selenium Metabolism and SelenoproteinsTXNRD3IT1;SELENBP1;TXNRD2;DIO2;MSRB1;SELT;SP3;TRNAU1AP;CREM
Selenocompound metabolismMARS2;SPS2;TXNRD2;PAPSS2;TXNRD1;TRR1;CCBL2;PSTK;PAPSS1

TXNRD2 has several biochemical functions, for example, flavin adenine dinucleotide binding, protein binding, thioredoxin-disulfide reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TXNRD2 itself. We selected most functions TXNRD2 had, and list some proteins which have the same functions with TXNRD2. You can find most of the proteins on our site.

Function Related Protein
flavin adenine dinucleotide bindingACADS;MTHFR;KDM1A;DUS3L;ACOX1;NOS2;D2HGDH;AOX3;GULO
protein bindingCDK4;SDC2;AGTRAP;ANKZF1;HLTF;STAT5A;ZNF703;C1orf35;CNIH2
thioredoxin-disulfide reductase activityTXNRD1;TXNRD3;TXNRD2;TRR1;NXN

TXNRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TXNRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TXNRD2.


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