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Official Full Name thioredoxin reductase 2
Background The reduced form of thioredoxin serves as a hydrogen donor, contributes to the up-regulation of various transcription factors and binds to and inhibits MAPKKK activity. Oxidized thioredoxin is converted back to the reduced form by Thioredoxin Reductase (TrxR2), a redox active enzyme. There are two distinct isoforms in mammalian cells, TrxR1, a cytosolic protein and TrxR2, almost exclusively a mitochondrial protein. TrxR expression is induced in several tumors.
Synonyms TXNRD2; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase beta; TR; TR3; TRXR2; thioredoxin reductase 3; thioredoxin reductase TR3; SELZ; TR-BETA
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TXNRD2-31640TH Recombinant Human TXNRD2, His-tagged E.coli His
    Human TXNRD2-3507H Recombinant Human TXNRD2, His-tagged E.coli His
    Mouse TXNRD2-17668M Recombinant Mouse TXNRD2 Protein Mammalian Cell His
    Rat TXNRD2-6379R Recombinant Rat TXNRD2 Protein Mammalian Cell His
    Cynomolgus Monkey TXNRD2-1067C Recombinant Cynomolgus TXNRD2 Protein, His-tagged Mammalian Cell His
    Chicken TXNRD2-3833C Recombinant Chicken TXNRD2 Mammalian Cell His

    txnrd2 involved in several pathways and played different roles in them. We selected most pathways txnrd2 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Oxidative Stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with txnrd2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular responses to stress RAD50; H3F3D; HSPA12B; Txn1; HIST1H1B; ATG7; UBN1; AMBRA1A; HSPA7; AMBRA1
    Detoxification of Reactive Oxygen Species Txn1; PRDX2; TXNRD2; TXN2; TXN; PRDX3
    Oxidative Stress NOX4; TXN2; TXNRD2; JUNBA; NQO1; NFIX
    Pyrimidine metabolism PNP6; NT5C1B; NT5C2B; NT5C3A; NME3; NME2B.1; CTPS1A; ENTPD3; POLR2H; POLR1E
    Selenium TXNRD2; SEPP1; FMN1; MSRB1
    Selenium Metabolism and Selenoproteins TRNAU1AP; TXNRD3IT1; SP3; SELENBP1; TXNRD2; DIO2; MSRB1; SELK; SELT; FBXO17
    Selenium Pathway CRP; TXNRD2; SAA2; SELT; PRDX2; SAA4; SEP15; DIO2; SAA2-SAA4; PRDX4
    Selenocompound metabolism TRR1; PSTK; PAPSS2A; MARS; INMT; MARS2; SEPSECS; CCBL2; SEPHS1; TXNRD2

    txnrd2 has several biochemical functions, for example, flavin adenine dinucleotide binding, protein binding, thioredoxin-disulfide reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by txnrd2 itself. We selected most functions txnrd2 had, and list some proteins which have the same functions with txnrd2. You can find most of the proteins on our site.

    Function Related Protein
    flavin adenine dinucleotide binding FMO1; CRY-DASH; AIFM4; MTO1; NOX4; GFER; AOX1; NOS3; FMO2; ACADSB
    protein binding TAC3; TSTD2; NAT8B; C14orf166; COG1; ARHGEF10; STX18; ALOX5AP; CDK16; GPN3
    thioredoxin-disulfide reductase activity TXNRD2; NXN; TXNRD3; TRR1; TXNRD1

    txnrd2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with txnrd2 here. Most of them are supplied by our site. Hope this information will be useful for your research of txnrd2.


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