Recombinant Rat Txnrd2 Protein, 490 residues
Cat.No. : | Txnrd2-15R |
Product Overview : | Recombinant Rat Thioredoxin Reductase 2 (Non-tagged, no signal peptide sequence, 490 residues) |
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Description : | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. |
Species : | Rat |
Protein length : | 490 residues |
Purity : | ≥ 95% as judged by gel analysis |
Unit definition : | 1 U of enzyme reduces 1 μmol DTNB per min in 0.5 mL standard DTNB assay containing 2.5 mM DTNB and 0.3 mM NADPH in TE buffer (50 mM Tris-HCl, 2 mM EDTA, pH 7.5) |
Applications : | DTNB assay; Insulin-coupled Thioredoxin assay; Inhibitor screening; etc. |
Notes : | Centrifuge the tube briefly before opening the lid. |
Concentration : | 0.2 mg/mL |
Storage Buffer : | TE buffer with 50% glycerol |
Shipping : | Shipped in cold pack by courier service. Store at -20 centigrade upon delivery. |
References : | 1. Cheng Q, Arnér ES. (2017) Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation. J Biol Chem. 292:5476-5487. 2. Arnér ES, Holmgren A. (2001) Measurement of thioredoxin and thioredoxin reductase. Curr Protoc Toxicol. Chapter 7:Unit 7.4. |
Gene Name : | Txnrd2 thioredoxin reductase 2 [ Rattus norvegicus ] |
Official Symbol : | Txnrd2 |
Synonyms : | TXNRD2; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3; Tr3; Trxr2; Trxrd2; MGC93435 |
Gene ID : | 50551 |
mRNA Refseq : | NM_022584 |
Protein Refseq : | NP_072106 |
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Not For Human Consumption!
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