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UBA7

  • Official Full Name

    ubiquitin-like modifier activating enzyme 7

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
  • Synonyms

    UBA7; ubiquitin-like modifier activating enzyme 7; UBE1L, ubiquitin activating enzyme E1 like; ubiquitin-like modifier-activating enzyme 7; D8; UBA1; ubiquitin activating enzyme E1 homolog B (yeast); UBA1B; ubiquitin activating enzyme E1; UBE2; MGC12713; UBA7_HUMAN; Ube 1L; UBE 2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; Ubiquitin-activating enzyme 7; Ubiquitin-activating enzyme E1 homolog; OTTHUMP00000212701; ubiquitin-activating enzyme-2; UBA7, ubiquitin-activating enzyme E1; UBA1, ubiquitin-activating enzyme E1 homolog B; ubiquitin; UBE1L;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBA7-171H Active Recombinant Human UBA7, His-tagged Insect Cell His
Human UBA7-629H Recombinant Human UBA7, His-tagged E.coli His
Human UBA7-833H Recombinant Human UBA7, GST-tagged Sf9 Insect Cell GST Full length
Human UBA7-5755H Recombinant Human UBA7 protein, His & T7-tagged E.coli His/T7 Lys429~Val488 (Accession # P41226)
Human UBA7-601HCL Recombinant Human UBA7 293 Cell Lysate HEK293 N/A
Human UBA7-2291H Recombinant Human UBA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UBA7-0050H Recombinant Human UBA7 Protein (D2-L1012), Tag Free Insect Cell No tag D2-L1012
Human UBA7-6310H Recombinant Human UBA7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBA7-1673HFL Recombinant Full Length Human UBA7 Protein, C-Flag-tagged Mammalian cells Flag
Human UBA7-0051H Recombinant Human UBA7 Protein (D2-L1012), His/Strep tagged Insect Cell His/Strep D2-L1012
Human UBA7-2291H-B Recombinant Human UBA7 Protein Pre-coupled Magnetic Beads HEK293
Human UBA7-6531H Recombinant Human UBA7 Protein (Lys429-Val488), N-His tagged E.coli N-His Lys429-Val488
Mouse Uba7-5756M Recombinant Mouse Uba7 protein, His & T7-tagged E.coli His/T7 Glu23~Tyr238 (Accession # Q9ET03)
Mouse Uba7-6770M Recombinant Mouse Uba7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Uba7-5757R Recombinant Rat Uba7 protein, His & T7-tagged E.coli His/T7 Arg249~Ser517 (Accession # D3ZEU5)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UBA7 involved in several pathways and played different roles in them. We selected most pathways UBA7 participated on our site, such as Ubiquitin mediated proteolysis, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisANAPC2;DET1;FANCL;CUL3B;BIRC8;ITCH;FBXW11A;KEAP1B;UBE2Z
Parkinsons diseaseCOX7B2;NDUFA10;APAF1;NDUFB11;NDUFA4;COX5A;ATP5J;SLC18A1;NDUFA11

UBA7 has several biochemical functions, for example, ATP binding, ISG15 activating enzyme activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBA7 itself. We selected most functions UBA7 had, and list some proteins which have the same functions with UBA7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPCCA;FLAD1;PAN3;ACSL5;PSKH1;UBE2D1B;DDX5;ACVR2B;MYHZ1.2
ISG15 activating enzyme activity
protein bindingCOG1;KCNA2;MAP2K3;NDUFA9;SUMO1;KIAA1737;NFATC1;ICAM3;SGK1
ubiquitin activating enzyme activityUBA7;UBA1;UBA6;ATG7;UBE1Y1;SAE1
ubiquitin-protein transferase activityRNF146;CBL;RNF25;RNF11;MALT1;PDZRN3B;MYCBP2;FBXO40.1;FBXL21

UBA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBA7.

ISG15; 15-deoxy-delta(12,14; SHFM1

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