UGT2B7
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Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide B7 -
Overview
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. -
Synonyms
UGT2B7;UDP glucuronosyltransferase 2 family, polypeptide B7;UDP glycosyltransferase 2 family, polypeptide B7;UDP-glucuronosyltransferase 2B7;UGT2B9;3 4 catechol estrogen specific;UDP glucuronosyltransferase 2 family polypeptide B7;UDP glucuronosyltransferase 2B7;UDP glucuronyltransferase family 2 beta 7;UDP glycosyltransferase 2 family polypeptide B7;UDPGT;UDPGTh 2;UDPGTh2;UGTB2B9;UDPGTh-2;UDPGT 2B7;3,4-catechol estrogen specific;UDP-glucuronosyltransferase 2B9;3,4-catechol estrogen-specific UDPGT;UDP-glucuronyltransferase, family 2, beta-7;UDPGT2B7;UDPGT 2B9
Recombinant Proteins
- Human
- Rat
- E.coli
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- HEK293
- His
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT2B7-2431H | Recombinant Human UGT2B7 protein, His-tagged | E.coli | Human | His | 25-351 aa | |
| Ugt2b7-604R | Recombinant Rat Ugt2b7 Protein, His-tagged | E.coli | Rat | His | Phe18~Val495 | |
| UGT2B7-209H | Recombinant Human UGT2B7, GST-tagged | Wheat Germ | Human | GST |
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| UGT2B7-6436R | Recombinant Rat UGT2B7 Protein | Mammalian Cells | Rat | His |
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| RFL23893HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (24-529) |
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| RFL26914RF | Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length of Mature Protein (18-530) |
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| UGT2B7-536H | Recombinant Human UGT2B7 Protein, His-tagged | E.coli | Human | His | Glu42-Ala419 |
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| UGT2B7-542HF | Recombinant Full Length Human UGT2B7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 529 amino acids |
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| UGT2B7-6092R | Recombinant Rat UGT2B7 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| UGT2B7-6092R-B | Recombinant Rat UGT2B7 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | GSTO1,GSTM4,CBR3,DHDHL,GSTM,GSTM3,UGT1A4,GSTA2,UGT1A6B,GSTM1 |
| Chemical carcinogenesis | CYP2C39,ALDH1A3,CYP1A1,CYP3A41B,MGST2,UGT1A1,ADH6,CYP2C38,UGT2A3,UGT1A7 |
| Pentose and glucuronate interconversions | UGT1A4,UGP2,ALDH2.2,UGP2B,GUSB,UGT2A3,ALDH3A2,UGT1A3,UGT1A7C,UGT1A7 |
| Metabolic pathways | FUT3,GCNT1,MMAB,NOS3,POLR2I,PPAP2C,COQ2,GUK1B,QDPRB1,ARSB |
| Drug metabolism - cytochrome P | AOX3,MGST3,GSTT1B,GSTA4,GSTT1,ALDH3A1,MGST1.2,FMO2,GSTA2,GSTT2B |
| Steroid hormone biosynthesis | CYP2C70,H2-KE6,UGT2B15,HSD3B2,CYP2D26,AKR1C3,CYP3A41B,CYP3A7,CYP2C54,CYP3A25 |
| Drug metabolism - other enzymes | UCKL1,NAT1,GMPS,UCK2B,TK2,TPMT.1,UPB1,ITPA,UPP2,PNAT3 |
| Retinol metabolism | RDH10B,RDH8A,CYP2A4,CYP26C1,UGT2B15,UGT1A9,SDR16C5,DHRS3,DHRS9,AOX4 |
| Starch and sucrose metabolism | AMY2A3,GPI1,UGP2B,GYS2,HK2,G6PC2,AGL,UGP2,UGT1A6,HKDC1 |
Protein Function
UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity,NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT retinoic acid binding | UGT1A6,UGT2B15,UGT1A4 |
| glucuronosyltransferase activity | GYLTL1B,LARGE,UGT1A6B,UGT8,UGT5G2,UGT5A3,UGT2A5,UGT1B5,UGT5A1,UGT1B3 |
Interacting Protein
UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.
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References
- Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).
- Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).
