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UGT2B7

Official Full Name

UDP glucuronosyltransferase 2 family, polypeptide B7
Overview

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
Synonyms

UGT2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glycosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7; UGT2B9; 3 4 catechol estrogen specific; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDPGT; UDPGTh 2; UDPGTh2; UGTB2B9; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7; UDPGT2B7; UDPGT 2B9;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Rat
Rattus norvegicus (Rat)

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT2B7-209H	Recombinant Human UGT2B7, GST-tagged	Wheat Germ	GST		Inquiry
Human	UGT2B7-536H	Recombinant Human UGT2B7 Protein, His-tagged	E.coli	His	Glu42-Ala419	Inquiry
Human	UGT2B7-542HF	Recombinant Full Length Human UGT2B7 Protein, GST-tagged	In Vitro Cell Free System	GST	529 amino acids	Inquiry
Human	UGT2B7-2431H	Recombinant Human UGT2B7 protein, His-tagged	E.coli	His	25-351 aa	$319 / 25μg
Rat	UGT2B7-6436R	Recombinant Rat UGT2B7 Protein	Mammalian Cell	His		Inquiry
Rat	UGT2B7-6092R	Recombinant Rat UGT2B7 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	Ugt2b7-604R	Recombinant Rat Ugt2b7 Protein, His-tagged	E.coli	His	Phe18~Val495	$298 / 10μg
Rat	UGT2B7-6092R-B	Recombinant Rat UGT2B7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL23893HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-529)	Inquiry
Rattus norvegicus (Rat)	RFL26914RF	Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (18-530)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	AKR1A1A;OXSR1;DCXR;UGT5G1;ALDH2;AKR1B8;UGP2A;Akr1b3;UGT1A9
Ascorbate and aldarate metabolism	ALDH9A1;UGT2A1;ALDH3A2A;UGT1AB;UGT1A3;ALDH3A2;UGDH;ALDH1B1;ALDH7A1
Steroid hormone biosynthesis	CYP19A1A;HSD3B2;UGT1A3;CYP7B1;HSD3B4;CYP3A41A;HSD17B6;CYP1A;UGT1AB
Starch and sucrose metabolism	UGT2B15;UGT1A9;AMY2A4;G6PCA.2;UGT1A6;TREH;KL;PGM2L1;GYS2
Retinol metabolism	RDH8B;CYP2C37;RDH5;RDH8;RDH10A;AOX2P;CYP3A41B;UGT1A9;RDH10
Porphyrin and chlorophyll metabolism	HMBSB;EARS2;HMOX1;HMOX1A;UGT1A7;COX15;UGT1A6A;PPOX;HMOX2
Metabolism of xenobiotics by cytochrome P	GSTA3;GSTM2;EPHX1;UGT2B7;UGT1A6A;UGT1A2;GSTA1;AKR7A2;HSD11B1
Drug metabolism - cytochrome P	AOX3;UGT1A2;ALDH3B1;AOX2P;MGST1.2;FMO6P;MGST3;MGST2;FMO5
Drug metabolism - other enzymes	TPMT;HPRT1;UCKL1;UGT1A6;UMPS;UGT1AB;UGT1A3;UCK1;UGT1A7C
Metabolic pathways	ACAA2;LDHAL6B;ACADM;HAAO;IDO1;PCK2;HPD;COX5B;DPM2
Chemical carcinogenesis	CYP2C50;CYP1B1;MGST2;UGT1A2;EPHX1;SULT1A1;UGT2B7;ADH1B;AKR1C2

UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.

Function	Related Protein
glucuronosyltransferase activity	UGT1A2;UGT1B7;B3GAT3;UGT1A6A;UGT3A2;UGT5C3;UGT5A1;CSGALNACT1;EXT1
NOT retinoic acid binding	UGT1A4;UGT2B7;UGT2B15;UGT1A6

UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.

GABRA3

Research Area

Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).

Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).