UGT2B7

  • Official Full Name

    UDP glucuronosyltransferase 2 family, polypeptide B7

  • Overview

    The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
  • Synonyms

    UGT2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glycosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7; UGT2B9; 3 4 catechol estrogen specific; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDPGT; UDPGTh 2; UDPGTh2; UGTB2B9; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7; UDPGT2B7; UDPGT 2B9;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT2B7-209H Recombinant Human UGT2B7, GST-tagged Wheat Germ GST
Human UGT2B7-536H Recombinant Human UGT2B7 Protein, His-tagged E.coli N-His Glu42-Ala419
Human UGT2B7-542HF Recombinant Full Length Human UGT2B7 Protein, GST-tagged In Vitro Cell Free System GST 529 amino acids
Human UGT2B7-2431H Recombinant Human UGT2B7 protein, His-tagged E.coli His 25-351 aa
Rat UGT2B7-6436R Recombinant Rat UGT2B7 Protein Mammalian Cell His
Rat UGT2B7-6092R Recombinant Rat UGT2B7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ugt2b7-604R Recombinant Rat Ugt2b7 Protein, His-tagged E.coli His Phe18~Val495
Rat UGT2B7-6092R-B Recombinant Rat UGT2B7 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23893HF Recombinant Full Length Human Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-529)
Rattus norvegicus (Rat) RFL26914RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 2B7(Ugt2B7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (18-530)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsUGT1A7;DCXR;UGT1A7C;UGT2B7;AKR1A1B;UGT1A3;UGT2A3;UGT1A6B;ALDH3A2A
Ascorbate and aldarate metabolismUGT1A3;UGT1A6A;UGT1A2;ALDH9A1B;ALDH7A1;MIOX;UGDH;UGT2A2;UGT1A7C
Steroid hormone biosynthesisCYP7B1;CYP3A65;CYP3A25;HSD3B1;UGT2B7;HSD17B2;SRD5A1;UGT1A6;UGT1A2
Starch and sucrose metabolismG6PC;UGT1A7C;HKDC1;UGP2A;UGT2A1;UXS1;AMY2A5;UGT2A2;AMY2A3
Retinol metabolismDHRS4;RDH10B;UGT1A7C;LRAT;CYP2C18;CYP2C70;SDR16C5;RDH8;CYP4A10
Porphyrin and chlorophyll metabolismEARS2;ALAD;UGT5G1;UGT1A2;HMOX2A;P22;COX10;EPRS;UGT2A1
Metabolism of xenobiotics by cytochrome PGSTT2B;GSTM;GSTA3;CYP2F2;CBR3;UGT2A1;GSTM6;GSTA5;ALDH1A3
Drug metabolism - cytochrome PMAOA;UGT1A9;GSTP1;UGT1A3;UGT2B15;ALDH3B2;GSTM3;UGT1A6B;AOX2P
Drug metabolism - other enzymesXDH;UPB1;UGT1A4;UGT1A2;IMPDH2;ITPA;CES2;UCKL1;IMPDH1
Metabolic pathwaysOTC;EXT1;PNPLA2;DPAGT1;NADKD1;ASAH1;PGAM1A;HSD17B8;AMPD3B
Chemical carcinogenesisNAT2;CYP2C8;CYP2C18;GSTT2B;CYP2E1;MGST3;UGT1A1;GSTM6;UGT2B15

UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.

Function Related Protein
glucuronosyltransferase activityUGT8A;UGT1A3;UGT5B4;UGT1B2;UGT1A2;UGT5A3;UGT1A6B;UGT5A5;UGT5C2
NOT retinoic acid bindingUGT2B15;UGT1A6;UGT1A4;UGT2B7

UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.

GABRA3

Research Area

Related articles

Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).
Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).
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