UGT2B7 Protein


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Official Full Name UDP glucuronosyltransferase 2 family, polypeptide B7
Background The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.
Synonyms UGT2B7; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP glycosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase 2B7; UGT2B9; 3 4 catechol estrogen specific; UDP glucuronosyltransferase 2 family polypeptide B7; UDP glucuronosyltransferase 2B7; UDP glucuronyltransferase family 2 beta 7; UDP glycosyltransferase 2 family polypeptide B7; UDPGT; UDPGTh 2; UDPGTh2; UGTB2B9; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7; UDPGT2B7; UDPGT 2B9
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT2B7-2431H Recombinant Human UGT2B7 protein, His-tagged E.coli His
    Human UGT2B7-536H Recombinant Human UGT2B7 Protein, His-tagged E.coli N-His
    Human UGT2B7-209H Recombinant Human UGT2B7, GST-tagged Wheat Germ GST
    Rat Ugt2b7-604R Recombinant Rat Ugt2b7 Protein, His-tagged E.coli His
    Rat UGT2B7-6436R Recombinant Rat UGT2B7 Protein Mammalian Cell His

    UGT2B7 involved in several pathways and played different roles in them. We selected most pathways UGT2B7 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT2B7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions UGT2A3; DHDH; UGT1A6; UGP2A; UGT1A1; AKR1A1B; GUSB; CRYL1; DHDHL; UGT1A9
    Ascorbate and aldarate metabolism UGT2B7; UGT1A2; ALDH7A1; UGT2A3; UGT1A6; UGT2A2; UGT1A4; UGT1A1; UGT1A6A; UGT1A6B
    Steroid hormone biosynthesis HSD3B5; CYP2C37; SULT1E1; CYP2C54; HSD17B1; HSD17B7; COMTB; UGT1A2; CYP3A65; CYP21A1
    Starch and sucrose metabolism UGT1A4; PYGB; AMY2B; HK3; HK1; G6PC; UGT2A3; GBE1; UGT2A1; GPI1
    Retinol metabolism CYP2C55; RDH8B; CYP2C54; RDH8; CYP3A65; UGT1A2; AOX4; DGAT1A; UGT2A1; UGT1A3
    Porphyrin and chlorophyll metabolism HCCSA.1; UGT1A6A; UGT1A6; UGT1A4; HMBSB; HCCSB; P22; MMAB; COX10; UGT1A2
    Metabolism of xenobiotics by cytochrome P HSD11B1; AKR7A3; GSTT2; AKR7A5; CBR3; CYP2F2; DHDHL; CBR1; GSTA2; UGT1A7
    Drug metabolism - cytochrome P FMO1; FMO4; FMO5; GSTT2B; UGT2B7; GSTA2; UGT1A1; GSTM5; FMO6P; GSTM2
    Drug metabolism - other enzymes CES2; UGT2A3; DPYDB; IMPDH1B; UPP1; PNAT3; CYP2A6; UCKL1; UCK2A; XDH
    Metabolic pathways CKB; NDUFV3; PNPLA3; ATP6V0A1; GGT6; NME1; NDUFV2; Atp5g2; MAT2AL; ALLC
    Chemical carcinogenesis MGST2; CYP2B19; ADH1A; UGT2B7; CYP2C55; GSTO2; ADH5; GSTM7; CYP2C50; CCBL1

    UGT2B7 has several biochemical functions, for example, glucuronosyltransferase activity, NOT retinoic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT2B7 itself. We selected most functions UGT2B7 had, and list some proteins which have the same functions with UGT2B7. You can find most of the proteins on our site.

    Function Related Protein
    glucuronosyltransferase activity UGT5A1; UGT1A4; UGT2B15; UGT1B5; CSGALNACT1; UGT5D1; B3GAT3; UGT1B1; UGT1B2; GYLTL1B
    NOT retinoic acid binding UGT1A6; UGT2B7; UGT1A4; UGT2B15

    UGT2B7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT2B7 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT2B7.


    Fujiwara, R; Itoh, T; et al. Extensive Protein-Protein Interactions Involving UDP-glucuronosyltransferase (UGT) 2B7 in Human Liver Microsomes. DRUG METABOLISM AND PHARMACOKINETICS 29:259-265(2014).
    Pazik, J; Oldak, M; et al. Uridine Diphosphate Glucuronosyltransferase 2B7 Variant p.His268Tyr as a Predictor of Kidney Allograft Early Acute Rejection. TRANSPLANTATION PROCEEDINGS 45:1516-1519(2013).

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