Recombinant Mouse Unc5b Protein, MYC/DDK-tagged

• Cat.No.: Unc5b-330M
• Product Overview: Purified recombinant protein of full-length mouse unc-5 homolog B (C. elegans) (cDNA clone MGC:66787 IMAGE:6417563), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
• Source: HEK293T
• Species: Mouse
• Tag: MYC/DDK
• Molecular Mass: 134.6 kDa
• Purity: >80%, as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Unc5b unc-5 netrin receptor B [ Mus musculus (house mouse) ]
• Official Symbol: Unc5b
• Synonyms: Unc5b; unc-5 netrin receptor B; Unc5h2; A630020F16; D10Bwg0792e; 6330415E02Rik; netrin receptor UNC5B; protein unc-5 homolog 2; protein unc-5 homolog B; unc5 homolog 2
• Gene ID: 107449
• mRNA Refseq: NM_029770
• Protein Refseq: NP_084046
• UniProt ID: Q8K1S3