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Official Full Name ubiquitin specific peptidase 15
Background This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.
Synonyms USP15; ubiquitin specific peptidase 15; ubiquitin specific protease 15; ubiquitin carboxyl-terminal hydrolase 15; KIAA0529; UNPH4; Deubiquitinating enzyme 15; Deubiquitinating enzyme; EC 3 1 2 15; MGC131982; MGC149838; MGC74854; Ubiquitin Carboxy terminal Hydrolase 15; Ubiquitin specific processing protease 15; Ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; UBP 15; UBP15; UBP15_HUMAN; Unph 2; UNPH 4; Unph-2; Unph2; USP 15; OTTHUMP00000243156; OTTHUMP00000243158
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Spodoptera frugiperda, Sf 21 (baculovirus)
    • Tag :
    • GST
    • His
    • SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP15-301633H Recombinant Human USP15 protein, GST-tagged E.coli GST
    Human USP15-148H Recombinant Human USP15, His-SUMO-tagged E.coli His/SUMO
    Human USP15-15881H Recombinant Human USP15, His-tagged E.coli His
    Human USP15-185H Recombinant Human USP15 E.coli N/A
    Human USP15-358H Recombinant Human USP15 Protein, His-tagged Spodoptera frugiperda, Sf 21 (baculovirus) His
    Human USP15-361H Recombinant Human USP15 Protein, GST-tagged E.coli GST
    Human USP15-682H Recombinant Human USP15 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human USP15-822H Recombinant Human USP15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse USP15-17904M Recombinant Mouse USP15 Protein Mammalian Cell His
    Mouse Usp15-6866M Recombinant Mouse Usp15 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat USP15-6470R Recombinant Rat USP15 Protein Mammalian Cell His
    Rhesus Macaque USP15-5122R Recombinant Rhesus monkey USP15 Protein, His-tagged Mammalian Cell His
    Chicken USP15-6403C Recombinant Chicken USP15 Mammalian Cell His

    USP15 involved in several pathways and played different roles in them. We selected most pathways USP15 participated on our site, such as Downregulation of TGF-beta receptor signaling, Integrated Breast Cancer Pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downregulation of TGF-beta receptor signaling PMEPA1; UCHL5; STUB1; SMAD3B; USP15; STRAP
    Integrated Breast Cancer Pathway SMARCA4; DCAKD; NOXA1; PLK3; UBE2F; DAG1; MYT1; GDI1; CYP19A1; ZMIZ1
    Signal Transduction RARG; ADCYAP1B; CRHR2; ARHGAP9; AKAP13; ARHGAP20; RBBP5; DEPDC7; IFT122; SST1.1
    Signaling by TGF-beta Receptor Complex UCHL5; SKIA; USP9; SKIB; STRAP; SKILB; TRIM33; NEDD8L; CGNB; PMEPA1
    TGF-beta receptor signaling activates SMADs PMEPA1; NEDD8; NEDD8L; UCHL5; STRAP; USP15

    USP15 has several biochemical functions, for example, SMAD binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP15 itself. We selected most functions USP15 had, and list some proteins which have the same functions with USP15. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity USP1; CTSJ; CASPA; USP27X; CTSSA; CTSF; USP48; USP24; CTSS; USP43
    identical protein binding VAMP2; GBP5; HCN2; ZNHIT6; ALS2CL; NUP153; SH3GL1; ORAI1; DACT3; AIM2
    protein binding MAP1LC3C; JAG2; PLK1S1; DHX30; IWS1; RTN4RL2B; ATF4; DCC; POLM; KCNA2
    transforming growth factor beta receptor binding LFT1; NODAL; SPAW; BMP4; GDF3; INHBC; USP15; TGFB1A; GDF9; INHBB
    ubiquitin-specific protease activity USP9; USP28; ATXN3; OTUD5A; USP6; OTUB1B; USP8; USP43A; OTUD3; ZRANB1B
    ubiquitinated histone binding USP15

    USP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP15.

    TRIM21; CCDC57; SPDL1; CARD9; MAD1L1

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