USP15
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Official Full Name
ubiquitin specific peptidase 15
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Overview
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. -
Synonyms
USP15; ubiquitin specific peptidase 15; ubiquitin specific protease 15; ubiquitin carboxyl-terminal hydrolase 15; KIAA0529; UNPH4; Deubiquitinating enzyme 15; Deubiquitinating enzyme; EC 3 1 2 15; MGC131982; MGC149838; MGC74854; Ubiquitin Carboxy terminal Hydrolase 15; Ubiquitin specific processing protease 15; Ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; UBP 15; UBP15; UBP15_HUMAN; Unph 2; UNPH 4; Unph-2; Unph2; USP 15; OTTHUMP00000243156; OTTHUMP00000243158;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Spodoptera frugiperda, Sf 21 (baculovirus)
- GST
- His
- His (Fc)
- Avi
- SUMO
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- USP15 Related Research Area
USP15 involved in several pathways and played different roles in them. We selected most pathways USP15 participated on our site, such as Downregulation of TGF-beta receptor signaling, Integrated Breast Cancer Pathway, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Downregulation of TGF-beta receptor signaling | PMEPA1;STRAP;STUB1;UCHL5;SMAD3B;USP15 |
| Integrated Breast Cancer Pathway | RPP38;CYP19A1;DHTKD1;USP38;SMARCA4;JAKMIP1;AHR;CCNB1IP1;USP16 |
| Signal Transduction | RIT1;PRC1B;PYY;GDI1;SOX9A;CNGA1;GPR37L1;ARHGAP33;NPS |
| Signaling by TGF-beta Receptor Complex | USP9;CGNB;UCHL5;STRAP;SKILB;SKIB;NEDD8;USP9X;TRIM33 |
| TGF-beta receptor signaling activates SMADs | USP15;PMEPA1;NEDD8;UCHL5;STRAP;NEDD8L |
USP15 has several biochemical functions, for example, SMAD binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP15 itself. We selected most functions USP15 had, and list some proteins which have the same functions with USP15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SMAD binding | AXIN1;SKOR1B;SNW1;PURB;RNF111;SKIB;SKIL;HIPK2;TGFBR3 |
| cysteine-type endopeptidase activity | USP2A;USP33;PDIA3;MALT1;CTSZ;SFRP1;CTSO;CASP1;USP3 |
| identical protein binding | PICK1;DAPK1;SMAD4;PLEKHH2;TRIM5;L3MBTL1;BCAT1;C10orf88;SMAD3 |
| protein binding | NOS3;GALNT3;DAPK1;SULT1A1;PLEKHH2;TFF3;EGFR;SOCS4;ELMO2 |
| transforming growth factor beta receptor binding | GDF1;GDF6B;BMP7B;GDF7;AMH;GDF3;INHBB;BMP2;MSTN |
| ubiquitin-specific protease activity | DUB1;USP40;USP31;USP2;USP15;USP28;JOSD2;USP38;USP20 |
| ubiquitinated histone binding |
USP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP15.
TRIM21; CCDC57; SPDL1; CARD9; MAD1L1
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