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  • Official Full Name

    ubiquitin specific peptidase 5 (isopeptidase T)

  • Overview

    Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse;cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A;late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin;monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end;of the chain (Wilkinson et al., 1995 (PubMed 7578059)).
  • Synonyms

    USP5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin carboxyl-terminal hydrolase 5; IsoT; isopeptidase T; ubiquitin isopeptidase T; ubiquitin thioesterase 5; deubiquitinating enzyme 5; ubiquitin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human USP5-158H Active Recombinant Human USP5 protein, His-tagged E.coli His
Human USP5-3633H Recombinant Human USP5, GST-tagged E.coli GST 1-300
Human USP5-1182H Recombinant Human USP5, His tagged Insect Cell His Met 1-Ser 835
Human USP5-561HCL Recombinant Human USP5 cell lysate Insect Cell N/A
Human USP5-0299H Recombinant Human USP5 Protein (A2-S858), His tagged E.coli His A2-S858
Human USP5-681H Recombinant Human USP5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human USP5-1254H Recombinant Human USP5 protein, GST-tagged E.coli GST
Human USP5-0300H Recombinant Human USP5 Protein (A2-S858), Tag Free E.coli No tag A2-S858
Mouse USP5-17937M Recombinant Mouse USP5 Protein Mammalian Cell His
Mouse USP5-9973M-B Recombinant Mouse USP5 Protein Pre-coupled Magnetic Beads HEK293
Mouse USP5-9973M Recombinant Mouse USP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Usp5-6881M Recombinant Mouse Usp5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque USP5-5130R Recombinant Rhesus monkey USP5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque USP5-4943R-B Recombinant Rhesus Macaque USP5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque USP5-4943R Recombinant Rhesus Macaque USP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish USP5-12776Z Recombinant Zebrafish USP5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • USP5 Related Research Area

USP5 involved in several pathways and played different roles in them. We selected most pathways USP5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

USP5 has several biochemical functions, for example, cysteine-type endopeptidase activity, omega peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP5 itself. We selected most functions USP5 had, and list some proteins which have the same functions with USP5. You can find most of the proteins on our site.

Function Related Protein
cysteine-type endopeptidase activityCTSSB.2;USP3;USP19;CASP8L1;MALT1A;CASP6L2;ATG4C;CTSLA;USP2
omega peptidase activityATXN3L;USP13;USP5;JOSD2;UCHL1;JOSD1;UCHL5;APEH;GGH
ubiquitin bindingVPS28;OTUB1B;OTUB2;RNF31;NEDD4;CRY1;TRIM32;TSG101;SIRT2
ubiquitin-specific protease activityOTUD7A;OTUD5B;USP17L2;USP43;OTUD3;USP19;USP7;USP12;USP25

USP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP5.

DAZAP2; TMEM239; TADA3; UBC; ub6l2_human; RAD23B; USP13; TNFRSF10D; PRKAB1; DVL2; RNF11

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