USP5 Protein


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Official Full Name ubiquitin specific peptidase 5 (isopeptidase T)
Background Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse;cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A;late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin;monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end;of the chain (Wilkinson et al., 1995 (PubMed 7578059)).
Synonyms USP5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); ubiquitin carboxyl-terminal hydrolase 5; IsoT; isopeptidase T; ubiquitin isopeptidase T; ubiquitin thioesterase 5; deubiquitinating enzyme 5; ubiquitin
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human USP5-1182H Recombinant Human USP5, His tagged Insect Cell His
    Human USP5-158H Recombinant Human USP5 protein, His-tagged E.coli His
    Human USP5-3633H Recombinant Human USP5, GST-tagged E.coli GST
    Human USP5-561HCL Recombinant Human USP5 cell lysate Insect Cell N/A
    Human USP5-681H Recombinant Human USP5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse USP5-17937M Recombinant Mouse USP5 Protein Mammalian Cell His
    Mouse Usp5-6881M Recombinant Mouse Usp5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque USP5-5130R Recombinant Rhesus monkey USP5 Protein, His-tagged Mammalian Cell His
    Zebrafish USP5-12776Z Recombinant Zebrafish USP5 Mammalian Cell His

    USP5 involved in several pathways and played different roles in them. We selected most pathways USP5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    USP5 has several biochemical functions, for example, cysteine-type endopeptidase activity, omega peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP5 itself. We selected most functions USP5 had, and list some proteins which have the same functions with USP5. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity USP20; CASP6L1; CASPB; USP37; ATG4B; USP51; USP17L2; FMNL3; USP42; USP9X
    omega peptidase activity UCHL5; USP5; USP13; UCHL1; GGH; ATXN3; APEH; JOSD2; JOSD1; ATXN3L
    protein binding FGF1; ANK2; HTN1; RFX5; ACAD9; ZNF155; MED25; CCL5; PKN2; RAP1GDS1
    ubiquitin binding USP16; UBXN11; BRAP; AUP1; OTUB1; FAF2; BCL10; NUP62; KCNS1; OTUB1A
    ubiquitin-specific protease activity EIF3F; BRCC3; USP37; USP47; TNFAIP3; USP12A; USP34; USP20; USP19; USP17L2
    zinc ion binding FHL3; TRIM54; RBM4.1; PNMA3; DNMT5; OAS2; MSL2B; RAI1; FTR14; TAF3

    USP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP5.

    DAZAP2; TMEM239; TADA3; UBC; ub6l2_human; RAD23B; USP13; TNFRSF10D; PRKAB1; DVL2; RNF11

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